{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:03:40Z","timestamp":1790633020747,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Maeil Health Nutrition Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) The purpose of this study was to investigate the effect of whey protein supplementation under dietary control on improvements in muscle mass and function following resistance exercise training. (2) Thirty-two men were randomly assigned to a whey protein supplementation group taking whey protein isolate (PSG, n = 17) and a placebo group (CON, n = 15). Participants were provided with three meals per day corresponding to the estimated individual daily energy intake. The supervised resistance exercise program was conducted 60 min per day, six days per week, for four weeks. (3) Post-intervention, there was a significant interaction between groups in terms of muscle mass increase (p = 0.033, \u03b72 = 0.14), with a greater increase in the PSG. There were also significant interactions between the groups and increases in peak torque of the dominant knee flexors (p = 0.048, \u03b72 = 0.12), dominant shoulder extensors, and non-dominant shoulder extensors (p = 0.028, \u03b72 = 0.15; p = 0.015, \u03b72 = 0.18), and the total work of the dominant knee and shoulder extensors (p = 0.012, \u03b72 = 0.19; p = 0.013, \u03b72 = 0.19), with greater increases in the PSG. (4) These results suggest that whey protein supplementation enhances resistance exercise-induced increase in muscle mass and overall muscular strength and endurance, independent of dietary influence.<\/jats:p>","DOI":"10.3390\/nu15041003","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T01:32:56Z","timestamp":1676597576000},"page":"1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of Whey Protein Supplement on 4-Week Resistance Exercise-Induced Improvements in Muscle Mass and Isokinetic Muscular Function under Dietary Control"],"prefix":"10.3390","volume":"15","author":[{"given":"Chae-Been","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Sport Science, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Sport Science, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung-Su","family":"Park","sequence":"additional","affiliation":[{"name":"R&D Group, Maeil Health Nutrition Co., Ltd., Pyeongtaek 17714, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"R&D Group, Maeil Health Nutrition Co., Ltd., Pyeongtaek 17714, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Sport Science, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Davies, R.W., Carson, B.P., and Jakeman, P.M. (2018). The effect of whey protein supplementation on the temporal recovery of muscle function following resistance training: A systematic review and meta-analysis. Nutrients, 10.","DOI":"10.3390\/nu10020221"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.20463\/jenb.2019.0015","article-title":"Effects of whey protein supplementation prior to, and following, resistance exercise on body composition and training responses: A randomized double-blind placebo-controlled study","volume":"23","author":"Park","year":"2019","journal-title":"J. Exerc. Nutr. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1728-869X(10)60014-7","article-title":"Impact of protein supplements on muscle recovery after exercise-induced muscle soreness","volume":"8","author":"Burnley","year":"2010","journal-title":"J. Exerc. Sci. Fit."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.appet.2016.04.020","article-title":"Benefit beliefs about protein supplements: A comparative study of users and non-users","volume":"103","author":"Hartmann","year":"2016","journal-title":"Appetite"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Galvan, E., Arentson-Lantz, E., Lamon, S., and Paddon-Jones, D. (2016). Protecting skeletal muscle with protein and amino acid during periods of disuse. Nutrients, 8.","DOI":"10.3390\/nu8070404"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1550-2783-9-54","article-title":"Protein timing and its effects on muscular hypertrophy and strength in individuals engaged in weight-training","volume":"9","author":"Stark","year":"2012","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13643-019-1039-z","article-title":"Effectiveness of whey protein supplements on the serum levels of amino acid, creatinine kinase and myoglobin of athletes: A systematic review and meta-analysis","volume":"8","author":"Lam","year":"2019","journal-title":"Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/nu5030852","article-title":"Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans","volume":"5","author":"Dideriksen","year":"2013","journal-title":"Nutrients"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphys.2015.00245","article-title":"Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy","volume":"6","author":"Morton","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3945\/jn.114.203208","article-title":"Role of ingested amino acids and protein in the promotion of resistance exercise\u2013induced muscle protein anabolism","volume":"146","author":"Reidy","year":"2016","journal-title":"J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12986-016-0124-8","article-title":"The impact of protein quality on the promotion of resistance exercise-induced changes in muscle mass","volume":"13","author":"Phillips","year":"2016","journal-title":"Nutr. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"959.e1","DOI":"10.1016\/j.jamda.2016.07.002","article-title":"Protein supplementation does not significantly augment the effects of resistance exercise training in older adults: A systematic review","volume":"17","author":"Thomas","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1550-2783-10-53","article-title":"The effect of protein timing on muscle strength and hypertrophy: A meta-analysis","volume":"10","author":"Schoenfeld","year":"2013","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3945\/ajcn.112.037556","article-title":"Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: A meta-analysis","volume":"96","author":"Cermak","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s40279-015-0403-y","article-title":"Effects of whey protein alone or as part of a multi-ingredient formulation on strength, fat-free mass, or lean body mass in resistance-trained individuals: A meta-analysis","volume":"46","author":"Naclerio","year":"2016","journal-title":"Sports Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s40279-014-0269-4","article-title":"Effects of protein supplementation in older adults undergoing resistance training: A systematic review and meta-analysis","volume":"45","author":"Finger","year":"2015","journal-title":"Sports Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/07315724.2013.875365","article-title":"Effects of whey protein and resistance exercise on body composition: A meta-analysis of randomized controlled trials","volume":"33","author":"Miller","year":"2014","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/bjsports-2017-097608","article-title":"A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults","volume":"52","author":"Morton","year":"2018","journal-title":"Br. J. Sports Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/ajcn\/50.5.1133","article-title":"Issues in reproducibility and validity of dietary studies","volume":"50","author":"Block","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1188\/11.CJON.E114-E121","article-title":"Diet Assessment Methods: A Guide for Oncology Nurses","volume":"15","author":"Ralph","year":"2011","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_21","unstructured":"Korean Agency for Technology and Standards (2015). Korean 7th Anthropometric Survey (2015), Korean Agency for Technology and Standards."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1056\/NEJMcpc049017","article-title":"Case 25-2004: A 49-year-old woman with severe obesity, diabetes, and hypertension","volume":"351","author":"Pratt","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/07303084.1993.10606684","article-title":"Strength testing\u2014Predicting a one-rep max from reps-to-fatigue","volume":"64","author":"Brzycki","year":"1993","journal-title":"J. Phys. Educ. Recreat. Danc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1123\/ijsnem.16.3.233","article-title":"Effect of whey and soy protein supplementation combined with resistance training in young adults","volume":"16","author":"Candow","year":"2006","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1017\/S0007114521001550","article-title":"Comparison of the effect of soya protein and whey protein on body composition: A meta-analysis of randomised clinical trials","volume":"127","author":"Damaghi","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_26","first-page":"1","article-title":"The effect of resistance training in healthy adults on body fat percentage, fat mass and visceral fat: A systematic review and meta-analysis","volume":"52","author":"Wewege","year":"2021","journal-title":"Sports Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12970-021-00452-2","article-title":"Flexible vs. rigid dieting in resistance-trained individuals seeking to optimize their physiques: A randomized controlled trial","volume":"18","author":"Conlin","year":"2021","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/07315724.2020.1815607","article-title":"Efficacy of L-Leucine supplementation coupled with a calorie-restricted diet to promote weight loss in mid-life women","volume":"40","author":"Funderburk","year":"2021","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1365-2265.2000.00937.x","article-title":"Effects of growth hormone administration on protein dynamics and substrate metabolism during 4 weeks of dietary restriction in obese women","volume":"52","author":"Richelsen","year":"2000","journal-title":"Clin. Endocrinol."},{"key":"ref_30","first-page":"307","article-title":"Use of [14 C]-sodium bicarbonate\/urea to measure total energy expenditure in overweight men and women before and after low calorie diet induced weight loss","volume":"15","author":"Luscombe","year":"2006","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.numecd.2009.04.007","article-title":"Short term effects of energy restriction and dietary fat sub-type on weight loss and disease risk factors","volume":"20","author":"Tapsell","year":"2010","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s40279-019-01106-9","article-title":"Exercise-induced changes in muscle size do not contribute to exercise-induced changes in muscle strength","volume":"49","author":"Loenneke","year":"2019","journal-title":"Sports Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00421-005-0127-z","article-title":"Independent and combined effects of liquid carbohydrate\/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men","volume":"97","author":"Bird","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.metabol.2004.07.012","article-title":"The effect of resistance training combined with timed ingestion of protein on muscle fiber size and muscle strength","volume":"54","author":"Andersen","year":"2005","journal-title":"Metab. Clin. Exp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2165\/00007256-200535100-00002","article-title":"Designing resistance training programmes to enhance muscular fitness","volume":"35","author":"Bird","year":"2005","journal-title":"Sports Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1097\/00005768-200109000-00020","article-title":"Effects of technique variations on knee biomechanics during the squat and leg press","volume":"33","author":"Escamilla","year":"2001","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_37","unstructured":"Floyd, R.T., and Thompson, C.W. (2009). Manual of Structural Kinesiology, McGraw-Hill."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.20463\/jenb.2017.0036","article-title":"The synergistic effect of protein complex supplementation combined with 12 weeks of resistance training on isokinetic muscular function in untrained young males","volume":"21","author":"Jang","year":"2017","journal-title":"J. Exerc. Nutr. Biochem."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/1003\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:38:39Z","timestamp":1760121519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/1003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["nu15041003"],"URL":"https:\/\/doi.org\/10.3390\/nu15041003","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}