{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:24:47Z","timestamp":1789619087872,"version":"build-2803163510"},"reference-count":94,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Technology Sydney"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as cough and wheezing that lead to irreversible airway damage and hyperresponsiveness. The primary risk factor for COPD is chronic cigarette smoke exposure, which promotes oxidative stress and a general pro-inflammatory condition by stimulating pro-oxidant and pro-inflammatory pathways and, simultaneously, inactivating anti-inflammatory and antioxidant detoxification pathways. These events cause progressive damage resulting in impaired cell function and disease progression. Treatments available for COPD are generally aimed at reducing the symptoms of exacerbation. Failure to regulate oxidative stress and inflammation results in lung damage. In the quest for innovative treatment strategies, phytochemicals, and complex plant extracts such as agarwood essential oil are promising sources of molecules with antioxidant and anti-inflammatory activity. However, their clinical use is limited by issues such as low solubility and poor pharmacokinetic properties. These can be overcome by encapsulating the therapeutic molecules using advanced drug delivery systems such as polymeric nanosystems and nanoemulsions. In this study, agarwood oil nanoemulsion (agarwood-NE) was formulated and tested for its antioxidant and anti-inflammatory potential in cigarette smoke extract (CSE)-treated BCi-NS1.1 airway basal epithelial cells. The findings suggest successful counteractivity of agarwood-NE against CSE-mediated pro-inflammatory effects by reducing the expression of the pro-inflammatory cytokines IL-1\u03b1, IL-1\u03b2, IL-8, and GDF-15. In addition, agarwood-NE induced the expression of the anti-inflammatory mediators IL-10, IL-18BP, TFF3, GH, VDBP, relaxin-2, IFN-\u03b3, and PDGF. Furthermore, agarwood-NE also induced the expression of antioxidant genes such as GCLC and GSTP1, simultaneously activating the PI3K pro-survival signalling pathway. This study provides proof of the dual anti-inflammatory and antioxidant activity of agarwood-NE, highlighting its enormous potential for COPD treatment.<\/jats:p>","DOI":"10.3390\/nu15041019","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T01:36:37Z","timestamp":1676856997000},"page":"1019","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Agarwood Oil Nanoemulsion Attenuates Cigarette Smoke-Induced Inflammation and Oxidative Stress Markers in BCi-NS1.1 Airway Epithelial Cells"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-396X","authenticated-orcid":false,"given":"Gabriele","family":"De Rubis","sequence":"first","affiliation":[{"name":"Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia"},{"name":"Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-2080","authenticated-orcid":false,"given":"Keshav Raj","family":"Paudel","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-6954","authenticated-orcid":false,"given":"Bikash","family":"Manandhar","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia"},{"name":"Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, 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Respir. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2101431","DOI":"10.1183\/13993003.01431-2021","article-title":"Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease","volume":"60","author":"Liu","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.arbres.2017.02.001","article-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary","volume":"53","author":"Vogelmeier","year":"2017","journal-title":"Arch. Bronconeumol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/ajhp\/zxz306","article-title":"Management of chronic obstructive pulmonary disease: A review focusing on exacerbations","volume":"77","author":"Bollmeier","year":"2020","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s10787-020-00698-3","article-title":"Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: An update","volume":"28","author":"Mehta","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/thoraxjnl-2020-216296","article-title":"Cigarette smoke exposure and alveolar macrophages: Mechanisms for lung disease","volume":"77","author":"Lugg","year":"2022","journal-title":"Thorax"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cbi.2018.12.009","article-title":"Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems","volume":"299","author":"Dua","year":"2019","journal-title":"Chemico.-Biological. Interactions"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4155\/fmc-2020-0297","article-title":"Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation","volume":"13","author":"Mehta","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4155\/fmc-2019-0338","article-title":"Recent advances in experimental animal models of lung cancer","volume":"12","author":"Malyla","year":"2020","journal-title":"Future Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Albano, G.D., Gagliardo, R.P., Montalbano, A.M., and Profita, M. (2022). Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases. Antioxidants, 11.","DOI":"10.3390\/antiox11112237"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.4049\/jimmunol.2001182","article-title":"Neutrophils and IL-1\u03b1 Regulate Surfactant Homeostasis during Cigarette Smoking","volume":"206","author":"Milad","year":"2021","journal-title":"J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Paudel, K.R., Panth, N., Manandhar, B., Singh, S.K., Gupta, G., Wich, P.R., Nammi, S., MacLoughlin, R., Adams, J., and Warkiani, M.E. (2022). Attenuation of Cigarette-Smoke-Induced Oxidative Stress, Senescence, and Inflammation by Berberine-Loaded Liquid Crystalline Nanoparticles: In Vitro Study in 16HBE and RAW264.7 Cells. Antioxidants, 11.","DOI":"10.3390\/antiox11050873"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1164\/ajrccm.155.5.9154890","article-title":"Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells","volume":"155","author":"Mio","year":"1997","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/imr.12616","article-title":"Interleukin-18: Biological properties and role in disease pathogenesis","volume":"281","author":"Kaplanski","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_15","first-page":"12","article-title":"IL-17A and GDF15 are able to induce epithelial-mesenchymal transition of lung epithelial cells in response to cigarette smoke","volume":"16","author":"Jiang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2090478","DOI":"10.1155\/2022\/2090478","article-title":"Peitu Shengjin Recipe Attenuates Airway Inflammation via the TLR4\/NF-kB Signaling Pathway on Chronic Obstructive Pulmonary Disease","volume":"2022","author":"Hu","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cca.2015.03.033","article-title":"Association of the biomarkers soluble ST2, galectin-3 and growth-differentiation factor-15 with heart failure and other non-cardiac diseases","volume":"445","author":"Mueller","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1074-7613(00)80013-8","article-title":"Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response","volume":"10","author":"Novick","year":"1999","journal-title":"Immunity"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2012-0173OC","article-title":"Role of IL-18 in second-hand smoke-induced emphysema","volume":"48","author":"Kratzer","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.1901330","article-title":"Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner","volume":"205","author":"Nieto","year":"2020","journal-title":"J. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tem.2012.03.006","article-title":"The endocrine effects of nicotine and cigarette smoke","volume":"23","author":"Tweed","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fendo.2019.00470","article-title":"The Vitamin D Binding Protein and Inflammatory Injury: A Mediator or Sentinel of Tissue Damage?","volume":"10","author":"Kew","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/pr100925p","article-title":"Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking","volume":"10","author":"Bortner","year":"2011","journal-title":"J. Proteome. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fphar.2020.00047","article-title":"Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target","volume":"11","author":"Kardas","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105792","DOI":"10.1016\/j.intimp.2019.105792","article-title":"Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory responses","volume":"75","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/jcmm.12802","article-title":"Protection from cigarette smoke-induced vascular injury by recombinant human relaxin-2 (serelaxin)","volume":"20","author":"Pini","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1007\/s00018-005-5484-6","article-title":"Structure of mammalian trefoil factors and functional insights","volume":"62","author":"Thim","year":"2005","journal-title":"Cell Mol. Life Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.17305\/bjbms.2017.1838","article-title":"Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo","volume":"17","author":"Belovari","year":"2017","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11655-011-0763-6","article-title":"Synergistic anti-inflammatory effect of Radix Platycodon in combination with herbs for cleaning-heat and detoxification and its mechanism","volume":"19","author":"Li","year":"2013","journal-title":"Chin. J. Integr. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"24301","DOI":"10.18632\/aging.202210","article-title":"Cigarette smoke extract induces airway epithelial cell death via repressing PRMT6\/AKT signaling","volume":"12","author":"Li","year":"2020","journal-title":"Aging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"L505","DOI":"10.1152\/ajplung.00406.2017","article-title":"Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage","volume":"314","author":"Duffney","year":"2018","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1465-9921-11-64","article-title":"Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke","volume":"11","author":"Modestou","year":"2010","journal-title":"Respir. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/resp.13032","article-title":"The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD","volume":"22","author":"Leung","year":"2017","journal-title":"Respirology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.23736\/S0026-4806.22.07972-1","article-title":"Role of oxidative stress in the pathogenesis of COPD","volume":"113","author":"Nucera","year":"2022","journal-title":"Minerva Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9152732","DOI":"10.1155\/2016\/9152732","article-title":"Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease","volume":"2016","author":"Panth","year":"2016","journal-title":"Adv. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1289\/ehp.834959","article-title":"The role of glutathione in detoxication","volume":"49","author":"Ketterer","year":"1983","journal-title":"Environ. Health Perspect."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cdp.2004.07.003","article-title":"Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer","volume":"28","author":"Mao","year":"2004","journal-title":"Cancer Detect. Prev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1465-9921-9-80","article-title":"Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity","volume":"9","author":"Harju","year":"2008","journal-title":"Respir. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4187\/respcare.05912","article-title":"Medication Regimens for Managing COPD Exacerbations","volume":"63","author":"Putcha","year":"2018","journal-title":"Respir Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62733","DOI":"10.1007\/s11356-022-21454-w","article-title":"Nutraceuticals and mitochondrial oxidative stress: Bridging the gap in the management of bronchial asthma","volume":"29","author":"Allam","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2003.09.002","article-title":"The anti-inflammatory potential of berberine in vitro and in vivo","volume":"203","author":"Kuo","year":"2004","journal-title":"Cancer Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e13954","DOI":"10.1111\/jfbc.13954","article-title":"Berberine loaded liquid crystalline nanostructure inhibits cancer progression in adenocarcinomic human alveolar basal epithelial cells in vitro","volume":"45","author":"Mehta","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1381612826666200728151610","article-title":"Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems","volume":"27","author":"Hardwick","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"104961","DOI":"10.1016\/j.tiv.2020.104961","article-title":"Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro","volume":"68","author":"Paudel","year":"2020","journal-title":"Toxicol. In Vitro"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.4155\/fmc-2020-0083","article-title":"Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549","volume":"12","author":"Solanki","year":"2020","journal-title":"Future Med. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41419-022-04826-5","article-title":"ROR activation by Nobiletin enhances antitumor efficacy via suppression of IkappaB\/NF-kappaB signaling in triple-negative breast cancer","volume":"13","author":"Kim","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Yoldi, M.J. (2021). Anti-Inflammatory and Antioxidant Properties of Plant Extracts. Antioxidants, 10.","DOI":"10.3390\/antiox10060921"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"112082","DOI":"10.1016\/j.jep.2019.112082","article-title":"Eriobotrya japonica leaf extract attenuates airway inflammation in ovalbumin-induced mice model of asthma","volume":"253","author":"Kim","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_50","first-page":"502182","article-title":"Terminalia chebula Fructus Inhibits Migration and Proliferation of Vascular Smooth Muscle Cells and Production of Inflammatory Mediators in RAW 264.7","volume":"2015","author":"Lee","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.3390\/molecules18033086","article-title":"Whole-tree agarwood-inducing technique: An efficient novel technique for producing high-quality agarwood in cultivated Aquilaria sinensis trees","volume":"18","author":"Liu","year":"2013","journal-title":"Molecules"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, S., Yu, Z., Wang, C., Wu, C., Guo, P., and Wei, J. (2018). Chemical Constituents and Pharmacological Activity of Agarwood and Aquilaria Plants. Molecules, 23.","DOI":"10.3390\/molecules23020342"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Alamil, J.M.R., Paudel, K.R., Chan, Y., Xenaki, D., Panneerselvam, J., Singh, S.K., Gulati, M., Jha, N.K., Kumar, D., and Prasher, P. (2022). Rediscovering the Therapeutic Potential of Agarwood in the Management of Chronic Inflammatory Diseases. Molecules, 27.","DOI":"10.3390\/molecules27093038"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4575030","DOI":"10.1155\/2020\/4575030","article-title":"Chemical Constituents and Anti-Inflammatory Effect of Incense Smoke from Agarwood Determined by GC-MS","volume":"2020","author":"Peng","year":"2020","journal-title":"Int. J. Anal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1573409911309030012","article-title":"Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity","volume":"9","author":"Yadav","year":"2013","journal-title":"Curr. Comput. Aided Drug Des."},{"key":"ref_56","first-page":"288","article-title":"Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals","volume":"1","author":"Chitre","year":"2007","journal-title":"Pharmacol. Online"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.phymed.2018.07.006","article-title":"The protective effects of Aquilariae Lignum Resinatum extract on 5-Fuorouracil-induced intestinal mucositis in mice","volume":"54","author":"Zheng","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1248\/bpb.b18-00805","article-title":"Agarwood Extract Mitigates Intestinal Injury in Fluorouracil-Induced Mice","volume":"42","author":"Wang","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"ref_59","first-page":"9944685","article-title":"Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation","volume":"2021","author":"Wang","year":"2021","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"ref_60","first-page":"1","article-title":"A biochemical study of agarwood on methanol injection in rat","volume":"8","author":"Hamouda","year":"2019","journal-title":"J. Drug Alcohol Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.fitote.2016.02.001","article-title":"Research progress on berberine with a special focus on its oral bioavailability","volume":"109","author":"Liu","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.2174\/1381612826666200610111013","article-title":"Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents","volume":"26","author":"Ng","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2217\/nnm-2021-0114","article-title":"Versatility of liquid crystalline nanoparticles in inflammatory lung diseases","volume":"16","author":"Chan","year":"2021","journal-title":"Nanomedicine"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"983583","DOI":"10.3389\/fmed.2022.983583","article-title":"Editorial: Advanced therapeutic delivery for the management of chronic respiratory diseases","volume":"9","author":"Paudel","year":"2022","journal-title":"Front. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.4155\/fmc-2022-0088","article-title":"Advances in research with rutin-loaded nanoformulations in mitigating lung diseases","volume":"14","author":"Paudel","year":"2022","journal-title":"Future Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Clarence, D.D., Paudel, K.R., Manandhar, B., Singh, S.K., Devkota, H.P., Panneerselvam, J., Gupta, V., Chitranshi, N., Verma, N., and Saad, S. (2022). Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases. Nutrients, 14.","DOI":"10.3390\/nu14183828"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13205-014-0214-0","article-title":"Nanoemulsion: An advanced mode of drug delivery system","volume":"5","author":"Jaiswal","year":"2015","journal-title":"3 Biotech"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/10717544.2022.2056663","article-title":"Nanodelivery of essential oils as efficient tools against antimicrobial resistance: A review of the type and physical-chemical properties of the delivery systems and applications","volume":"29","author":"Dupuis","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Alnuqaydan, A.M., Almutary, A.G., Azam, M., Manandhar, B., Yin, G.H.S., Yen, L.L., Madheswaran, T., Paudel, K.R., Hansbro, P.M., and Chellappan, D.K. (2022). Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine-Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061119"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e13572","DOI":"10.1111\/jfbc.13572","article-title":"Anti-inflammatory and anticancer activities of Naringenin-loaded liquid crystalline nanoparticles in vitro","volume":"45","author":"Wadhwa","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40169-015-0068-z","article-title":"Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer","volume":"4","author":"King","year":"2015","journal-title":"Clin. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ddr.21648","article-title":"Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases","volume":"81","author":"Chellappan","year":"2020","journal-title":"Drug Dev. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3389\/fmed.2020.00554","article-title":"Role of Lung Microbiome in Innate Immune Response Associated With Chronic Lung Diseases","volume":"7","author":"Paudel","year":"2020","journal-title":"Front. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2500\/aap.2015.36.3812","article-title":"Burden of chronic obstructive pulmonary disease: Healthcare costs and beyond","volume":"36","author":"May","year":"2015","journal-title":"Allergy Asthma Proc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1164\/rccm.200811-1757ST","article-title":"An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease","volume":"182","author":"Eisner","year":"2010","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4155\/fmc-2021-0097","article-title":"Mitochondrial dysfunctions associated with chronic respiratory diseases and their targeted therapies: An update","volume":"13","author":"Chellappan","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"17534666221075493","DOI":"10.1177\/17534666221075493","article-title":"Digital healthcare in COPD management: A narrative review on the advantages, pitfalls, and need for further research","volume":"16","author":"Watson","year":"2022","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Alqahtani, J.S. (2022). Prevalence, incidence, morbidity and mortality rates of COPD in Saudi Arabia: Trends in burden of COPD from 1990 to 2019. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0268772"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Devkota, H.P., Paudel, K.R., Khanal, S., Baral, A., Panth, N., Adhikari-Devkota, A., Jha, N.K., Das, N., Singh, S.K., and Chellappan, D.K. (2022). Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties. Molecules, 27.","DOI":"10.3390\/molecules27165219"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"115829","DOI":"10.1016\/j.jep.2022.115829","article-title":"Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review","volume":"301","author":"Zhao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Raman, S., Murugaiyah, V., and Parumasivam, T. (2022). Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview. Molecules, 27.","DOI":"10.3390\/molecules27196164"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1513\/pats.200411-056SF","article-title":"Pulmonary and systemic oxidant\/antioxidant imbalance in chronic obstructive pulmonary disease","volume":"2","author":"MacNee","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref_84","unstructured":"Pahwa, R., Goyal, A., and Jialal, I. (2022). Chronic Inflammation, StatPearls Publishing."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7432797","DOI":"10.1155\/2016\/7432797","article-title":"Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1165\/rcmb.2013-0348TR","article-title":"Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung","volume":"50","author":"Nyunoya","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Paudel, K.R., Mehta, M., Shukla, S.D., Panth, N., Chellappan, D.K., Dua, K., and Hansbro, P. (2022). Advancements in nanotherapeutics targeting senescence in chronic obstructive pulmonary disease. Nanomedicine.","DOI":"10.2217\/nnm-2021-0373"},{"key":"ref_88","first-page":"311","article-title":"Chapter 14\u2014Role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema","volume":"Volume 3","author":"Rezaei","year":"2022","journal-title":"Translational Autoimmunity"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.plefa.2014.10.006","article-title":"Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells","volume":"94","author":"Ma","year":"2015","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1183\/09031936.00158110","article-title":"Role of IL-1\u03b1 and the Nlrp3\/caspase-1\/IL-1\u03b2 axis in cigarette smoke-induced pulmonary inflammation and COPD","volume":"38","author":"Pauwels","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12931-022-02167-7","article-title":"IL-37 protects against airway remodeling by reversing bronchial epithelial-mesenchymal transition via IL-24 signaling pathway in chronic asthma","volume":"23","author":"Feng","year":"2022","journal-title":"Respir. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K","article-title":"IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes","volume":"28","author":"Hurme","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3389\/fimmu.2018.02061","article-title":"The Dual Nature of Type I and Type II Interferons","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Pungsrinont, T., Kallenbach, J., and Baniahmad, A. (2021). Role of PI3K-AKT-mTOR Pathway as a Pro-Survival Signaling and Resistance-Mediating Mechanism to Therapy of Prostate Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011088"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/1019\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:39:50Z","timestamp":1760121590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/1019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":94,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["nu15041019"],"URL":"https:\/\/doi.org\/10.3390\/nu15041019","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}