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Lacticaseibacillus rhamnosus ATCC 9595 is a strain with probiotic potential which shows immunomodulatory properties. The incorporation of this bacterium in food rich in bioactive compounds, such as cupua\u00e7u juice (Theobroma grandiflorum), could result in a product with interesting health properties. This work evaluated the effects of the oral administration of cupua\u00e7u juice fermented with L. rhamnosus on the outcome of LPS-induced endotoxemia in mice. C57BL\/6 mice (12\/group) received oral doses (100 \u00b5L) of saline solution and unfermented or fermented cupua\u00e7u juice (108 CFU\/mL). After 5 days, the endotoxemia was induced by an intraperitoneal injection of LPS (10 mg\/kg). The endotoxemia severity was evaluated daily using a score based on grooming behavior, mobility, presence of piloerection, and weeping eyes. After 6 h and 120 h, the mice (6\/group) were euthanized for analysis of cell counts (in peritoneal lavage and serum) and organ weight. L. rhamnosus grew in cupua\u00e7u juice and produced organic acids without the need for supplementation. The bacteria counts were stable in the juice during storage at 4 \u00b0C for 28 days. The fermentation with L. rhamnosus ATCC 9595 changed the metabolites profile of cupua\u00e7u juice due to the biotransformation and enhancement of some compounds. In general, the administration of L. rhamnosus-fermented juice allowed a significant improvement in several characteristics of endotoxemic status (weight loss, hypothermia, severity index, cell migration). In addition, treatment with fermented juice significantly reduced the weight of the spleen, liver, intestine, and kidneys compared to the saline-treated endotoxemic group. Taken together, our data show that short-term intake therapy of cupua\u00e7u juice fermented with L. rhamnosus ATCC 9595 can reduce systemic inflammation in an experimental model of LPS-induced endotoxemia in mice.<\/jats:p>","DOI":"10.3390\/nu15041059","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T01:39:28Z","timestamp":1676943568000},"page":"1059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Short-Term Intake of Theobroma grandiflorum Juice Fermented with Lacticaseibacillus rhamnosus ATCC 9595 Amended the Outcome of Endotoxemia Induced by Lipopolysaccharide"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-2223","authenticated-orcid":false,"given":"Adrielle","family":"Zagmignan","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Patogenicidade Microbiana, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gest\u00e3o de Servi\u00e7os e Programas de Sa\u00fade, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"},{"name":"Laborat\u00f3rio de Microbiologia Ambiental, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmim Costa","family":"Mendes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patogenicidade Microbiana, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle Pereira","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patogenicidade Microbiana, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle Damasceno Costa dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patogenicidade 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsander Rodrigues Carvalho","family":"Junior","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel Noguera","family":"Baz\u00e1n","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patogenicidade Microbiana, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edinalva Rodrigues","family":"Alves","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gest\u00e3o de Servi\u00e7os e Programas de Sa\u00fade, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Lima de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia Ambiental, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Karoline Maiorana","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Extra\u00e7\u00e3o e Cromatografia, Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Maranh\u00e3o, Campus Monte Castelo, S\u00e3o Lu\u00eds 65030-005, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-1184","authenticated-orcid":false,"given":"Wellyson da Cunha Ara\u00fajo","family":"Firmo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gest\u00e3o de Servi\u00e7os e Programas de Sa\u00fade, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, Brazil"},{"name":"Centro de Ci\u00eancias da Sa\u00fade, Campus Imperatriz, 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