{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:19:52Z","timestamp":1789237192735,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01754"],"award-info":[{"award-number":["PI17\/01754"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01754"],"award-info":[{"award-number":["PI17\/01754"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>To examine the associations of sociodemographic, lifestyle, and clinical factors with cardiometabolic risk and each of its components during pregnancy in a pregnant population from Catalonia (Spain). A prospective cohort study of 265 healthy pregnant women (39 \u00b1 5 years) in the first and third-trimesters. Sociodemographic, obstetric, anthropometric, lifestyle and dietary variables were collected, and blood samples were taken. The following cardiometabolic risk markers were evaluated: BMI, blood pressure, glucose, insulin, HOMA-IR, triglycerides, LDL, and HDL-cholesterol. From these, a cluster cardiometabolic risk (CCR)-z score was created by summating all z-scores (except insulin and DBP) computed for each risk factor. Data were analyzed using bivariate analysis and multivariable linear regression. In the multivariable models, the first-trimester CCRs was positively associated with overweight\/obesity status (\u03b2: 3.54, 95%CI: 2.73, 4.36) but inversely related to the level of education (\u03b2: \u22121.04, 95%CI: \u22121.94, 0.14) and physical activity (PA) (\u03b2: \u22121.21, 95%CI: \u22122.24, \u22120.17). The association between overweight\/obesity and CCR (\u03b2:1.91, 95%CI: 1.01, 2.82) persisted into the third-trimester, whereas insufficient GWG (\u03b2: \u22121.14, 95%CI: \u22121.98, \u22120.30) and higher social class (\u03b2: \u22122.28, 95%CI: \u22123.42, \u22121.13) were significantly associated with a lower CCRs. Starting pregnancy with normal weight, higher socioeconomic and educational levels, being a non-smoker, non-consumer of alcohol, and PA were protective factors against cardiovascular risk during pregnancy.<\/jats:p>","DOI":"10.3390\/nu15051135","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T01:37:52Z","timestamp":1677202672000},"page":"1135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-7610","authenticated-orcid":false,"given":"Ehsan","family":"Motevalizadeh","sequence":"first","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV), 43201 Reus, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-5629","authenticated-orcid":false,"given":"Andr\u00e9s","family":"D\u00edaz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV), 43201 Reus, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-3588","authenticated-orcid":false,"given":"Francisco","family":"Mart\u00edn-Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS), 08007 Barcelona, Spain"},{"name":"Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut d\u00b4Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS), 43202 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Basora","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS), 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-0975","authenticated-orcid":false,"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV), 43201 Reus, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS), 08007 Barcelona, Spain"},{"name":"Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut d\u00b4Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS), 43202 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fcvm.2020.00040","article-title":"Cardiometabolic Risk Factors in Pregnancy and Implications for Long-Term Health: Identifying the Research Priorities for Low-Resource Settings","volume":"7","author":"Nagraj","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_2","first-page":"52","article-title":"The Impact of Socio-Economic, Lifestyle Habits, and Obesity in Developing of Pregnancy-Induced Hypertension in Fast-Growing Country: Global Comparisons","volume":"40","author":"Bener","year":"2013","journal-title":"Clin. Exp. Obs. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/dme.12529","article-title":"The Association between Socio-Demographic Marginalization and Plasma Glucose Levels at Diagnosis of Gestational Diabetes","volume":"31","author":"Sampson","year":"2014","journal-title":"Diabet. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ppe.12531","article-title":"Neighbourhood Assets and Early Pregnancy Cardiometabolic Risk Factors","volume":"33","author":"Fabio","year":"2019","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.numecd.2021.04.019","article-title":"Influence of the Degree of Adherence to the Mediterranean Diet and Its Components on Cardiometabolic Risk during Pregnancy. The GESTAFIT Project","volume":"31","author":"Acosta","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/ppe.12279","article-title":"Maternal Dietary Patterns Are Associated with Lower Levels of Cardiometabolic Markers during Pregnancy","volume":"30","author":"Martin","year":"2016","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Al Wattar, B.H., Dodds, J., Placzek, A., Beresford, L., Spyreli, E., Moore, A., Gonzalez Carreras, F.J., Austin, F., Murugesu, N., and Roseboom, T.J. (2019). Mediterranean-Style Diet in Pregnant Women with Metabolic Risk Factors (ESTEEM): A Pragmatic Multicentre Randomised Trial. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002857"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1017\/S0007114512004242","article-title":"Favourable Effects of the Dietary Approaches to Stop Hypertension Diet on Glucose Tolerance and Lipid Profiles in Gestational Diabetes: A Randomised Clinical Trial","volume":"109","author":"Asemi","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"337.e1","DOI":"10.1016\/j.ajog.2011.05.013","article-title":"Major Dietary Patterns and Blood Pressure Patterns during Pregnancy: The Generation R Study","volume":"205","author":"Timmermans","year":"2011","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1136\/bjsports-2018-100056","article-title":"2019 Canadian Guideline for Physical Activity throughout Pregnancy","volume":"52","author":"Mottola","year":"2018","journal-title":"Br. J. Sport. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehab724.2893","article-title":"Arterial Hypertension in Pregnant Women: The Effect of Body Mass Index and Smoking","volume":"42","author":"Rublevskaya","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"66.e1","DOI":"10.1016\/j.ajog.2007.06.078","article-title":"In Utero Tobacco Exposure Is Associated with Modified Effects of Maternal Factors on Fetal Growth","volume":"198","author":"Porter","year":"2008","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Haskins, A.E., Bertone-Johnson, E.R., Pekow, P., Carbone, E., Fortner, R.T., and Chasan-Taber, L. (2010). Smoking during Pregnancy and Risk of Abnormal Glucose Tolerance: A Prospective Cohort Study. BMC Pregnancy Childbirth, 10.","DOI":"10.1186\/1471-2393-10-55"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1536\/ihj.38.497","article-title":"The Effect of Cigarette Smoking during Pregnancy on Cord Blood Lipid, Lipoprotein and Apolipoprotein Levels","volume":"38","author":"Iscan","year":"1997","journal-title":"Jpn Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.etap.2017.04.018","article-title":"The Effect of Passive and Active Exposure to Tobacco Smoke on Lipid Profile Parameters and the Activity of Certain Membrane Enzymes in the Blood of Women in the First Trimester of Pregnancy","volume":"53","author":"Milnerowicz","year":"2017","journal-title":"Env. Toxicol. Pharm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41440-018-0124-3","article-title":"Association between Alcohol Consumption during Pregnancy and Hypertensive Disorders of Pregnancy in Japan: The Japan Environment and Children\u2019s Study","volume":"42","author":"Iwama","year":"2019","journal-title":"Hypertens. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0026-0495(90)90007-Y","article-title":"Serum Lipids and Lipoproteins in Alcoholic Women during Pregnancy","volume":"39","author":"Keso","year":"1990","journal-title":"Metabolism"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yen, I.W., Lee, C.N., Lin, M.W., Fan, K.C., Wei, J.N., Chen, K.Y., Chen, S.C., Tai, Y.Y., Kuo, C.H., and Lin, C.H. (2019). Overweight and Obesity Are Associated with Clustering of Metabolic Risk Factors in Early Pregnancy and the Risk of GDM. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225978"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Roland, M.C.P., Lekva, T., Godang, K., Bollerslev, J., and Henriksen, T. (2020). Changes in Maternal Blood Glucose and Lipid Concentrations during Pregnancy Differ by Maternal Body Mass Index and Are Related to Birthweight: A Prospective, Longitudinal Study of Healthy Pregnancies. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232749"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12884-017-1543-x","article-title":"Maternal and Fetal Blood Lipid Concentrations during Pregnancy Differ by Maternal Body Mass Index: Findings from the ROLO Study","volume":"17","author":"Geraghty","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1001\/jama.2017.3635","article-title":"Association of Gestational Weight Gain With Maternal and Infant Outcomes: A Systematic Review and Meta-Analysis","volume":"317","author":"Goldstein","year":"2017","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1001\/jama.2019.3820","article-title":"Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes","volume":"321","author":"Voerman","year":"2019","journal-title":"JAMA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1123\/ijsnem.2021-0274","article-title":"The Protective Role of Physical Fitness on Cardiometabolic Risk During Pregnancy: The GESTAtion and FITness Project","volume":"32","author":"Acosta","year":"2022","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/dmrr.2803","article-title":"Clustering of Metabolic Risk Factors and Adverse Pregnancy Outcomes: A Prospective Cohort Study","volume":"32","author":"Lei","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Arija, V., Fargas, F., March, G., Abajo, S., Basora, J., Canals, J., Ribot, B., Aparicio, E., Serrat, N., and Hern\u00e1ndez-Mart\u00ednez, C. (2014). Adapting Iron Dose Supplementation in Pregnancy for Greater Effectiveness on Mother and Child Health: Protocol of the ECLIPSES Randomized Clinical Trial. BMC Pregnancy Childbirth, 14.","DOI":"10.1186\/1471-2393-14-33"},{"key":"ref_26","unstructured":"Institut d\u2019Estad\u00edstica de Catalunya (2013). Classificaci\u00f3 Catalana d\u2019ocupacions 2011 (CCO-2011). Adaptaci\u00f3 de La CNO-2011, Generalitat de Catalunya. Available online: https:\/\/www.idescat.cat\/serveis\/biblioteca\/docs\/cat\/cco2011.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"nzaa182","DOI":"10.1093\/cdn\/nzaa182","article-title":"Nutrition during Pregnancy: Findings from the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies\u2013Singleton Cohort","volume":"5","author":"Hinkle","year":"2021","journal-title":"Curr. Dev. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0306-4603(78)90024-2","article-title":"Measuring Degree of Physical Dependence to Tobacco Smoking with Reference to Individualization of Treatment","volume":"3","year":"1978","journal-title":"Addict. Behav."},{"key":"ref_29","first-page":"242","article-title":"Validation of a short questionnaire on frequency of dietary intake: Reproducibility and validity","volume":"23","author":"Ballart","year":"2008","journal-title":"Nutr. Hosp."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/ijpo.12092","article-title":"Mediterranean Dietary Pattern in Pregnant Women and Offspring Risk of Overweight and Abdominal Obesity in Early Childhood: The INMA Birth Cohort Study","volume":"11","author":"Romaguera","year":"2016","journal-title":"Pediatr. Obes."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","article-title":"Adherence to a Mediterranean Diet and Survival in a Greek Population","volume":"348","author":"Trichopoulou","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_32","unstructured":"World Health Organization (WHO) (2006). Global Dabatase on Body Mass Index, World Health Organization."},{"key":"ref_33","first-page":"2","article-title":"Institute of Medicine and National Research Council","volume":"Volume 1","author":"Kathleen","year":"2009","journal-title":"Weight Gain during Pregnancy: Reexamining the Guidelines"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1067\/mob.2002.126851","article-title":"Blood Pressure Patterns through Consecutive Pregnancies Are Influenced by Body Mass Index","volume":"187","author":"Strevens","year":"2002","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1034\/j.1600-0412.2001.080009824.x","article-title":"Blood Pressure during Pregnancy in a Swedish Population; Impact of Parity","volume":"80","author":"Strevens","year":"2001","journal-title":"Acta Obs. Gynecol. Scand."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ren, M., Li, H., Cai, W., Niu, X., Ji, W., Zhang, Z., Niu, J., Zhou, X., and Li, Y. (2018). Excessive Gestational Weight Gain in Accordance with the IOM Criteria and the Risk of Hypertensive Disorders of Pregnancy: A Meta-Analysis. BMC Pregnancy Childbirth, 18.","DOI":"10.1186\/s12884-018-1922-y"},{"key":"ref_37","first-page":"60","article-title":"Impact of Body Mass Index on Insulin Sensitivity\/Resistance in Pregnant Women with and without Gestational Diabetes Mellitus","volume":"40","author":"Genova","year":"2013","journal-title":"Acta Med. Bulg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jendso\/bvaa195","article-title":"Contribution of Gestational Weight Gain on Maternal Glucose Metabolism in Women with GDM and Normal Glucose Tolerance","volume":"5","author":"Alvarado","year":"2021","journal-title":"J. Endocr. Soc."},{"key":"ref_39","first-page":"bvaa195","article-title":"Association of Pre-Pregnancy Body Mass Index and Rate of Weight Gain during Pregnancy with Maternal Indicators of Cardiometabolic Risk","volume":"11","year":"2021","journal-title":"Nutr. Diabetes"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e734","DOI":"10.1210\/clinem\/dgab655","article-title":"Rate of Gestational Weight Gain and Glucose-Insulin Metabolism Among Hispanic Pregnant Women With Overweight and Obesity","volume":"107","author":"Lindsay","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e14504","DOI":"10.14814\/phy2.14504","article-title":"Sympathetic Nervous System Activity and Reactivity in Women with Gestational Diabetes Mellitus","volume":"8","author":"Reyes","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"865965","DOI":"10.1155\/2013\/865965","article-title":"Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity","volume":"2013","author":"Canale","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.arteri.2020.10.002","article-title":"Dyslipemias and Pregnancy, an Update","volume":"33","author":"Mauri","year":"2021","journal-title":"Cl\u00ednica E Investig. En Arterioscler."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2478\/v10011-009-0011-1","article-title":"Lipid Profile of Healthy Women During Normal Pregnancy","volume":"28","author":"Diareme","year":"2009","journal-title":"J. Med. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/humupd\/dmp050","article-title":"Maternal Metabolism and Obesity: Modifiable Determinants of Pregnancy Outcome","volume":"16","author":"Nelson","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/AOG.0b013e3181e45d23","article-title":"Prepregnancy Body Mass Index and Gestational Age-Dependent Changes in Lipid Levels during Pregnancy","volume":"116","author":"Vahratian","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_47","first-page":"139","article-title":"The Impact of Maternal Obesity and Gestational Weight Gain on Early and Mid-Pregnancy Lipid Profiles","volume":"176","author":"Scifres","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19865","DOI":"10.1038\/s41598-020-76845-1","article-title":"Association between Maternal Blood Lipids Levels during Pregnancy and Risk of Small-for-Gestational-Age Infants","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Brown, S.D., Hedderson, M.M., Ehrlich, S.F., Galarce, M.N., Tsai, A.L., Quesenberry, C.P., and Ferrara, A. (2019). Gestational Weight Gain and Optimal Wellness (GLOW): Rationale and Methods for a Randomized Controlled Trial of a Lifestyle Intervention among Pregnant Women with Overweight or Obesity. BMC Pregnancy Childbirth, 19.","DOI":"10.1186\/s12884-019-2293-8"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/1471-0528.13296","article-title":"Maternal Pre-Pregnancy BMI: Harbinger of Late-Pregnancy Maternal Lipid Profile","volume":"123","author":"Catalano","year":"2016","journal-title":"BJOG"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Amati, F., Hassounah, S., and Swaka, A. (2019). The Impact of Mediterranean Dietary Patterns during Pregnancy on Maternal and Offspring Health. Nutrients, 11.","DOI":"10.3390\/nu11051098"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1111\/acer.14193","article-title":"Changes in Alcohol Intake during Pregnancy in Spain, 1980 to 2014","volume":"43","author":"Cuevas","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3181\/00379727-182-3-RC1","article-title":"Oral Nicotine Induces an Atherogenic Lipoprotein Profile","volume":"182","author":"Mulligan","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3181\/00379727-182-3-RC2","article-title":"Oral Nicotine Impairs Clearance of Plasma Low Density Lipoproteins","volume":"182","author":"Hojnacki","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0002-8703(88)90649-7","article-title":"Lipid Effects of Smoking","volume":"115","year":"1988","journal-title":"Am. Heart J."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-V\u00e9lez, R., Lobelo, F., Aguilar-de Plata, A.C., Izquierdo, M., and Garc\u00eda-Hermoso, A. (2017). Exercise during Pregnancy on Maternal Lipids: A Secondary Analysis of Randomized Controlled Trial. BMC Pregnancy Childbirth, 17.","DOI":"10.1186\/s12884-017-1571-6"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chen, H., Zhang, C.J.P., Fang, X., Tan, Z., Yan, N., Ming, W.-K., and Wan, Z. (2021). Relationship of Objectively Measuring Physical Activity and Sitting Time on Plasma Lipid Metabolism During Pregnancy. Res. Sq., preprint.","DOI":"10.21203\/rs.3.rs-610850\/v1"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fphys.2018.00373","article-title":"Development of the Human Placenta and Fetal Heart: Synergic or Independent?","volume":"9","author":"Burton","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/jhh.2008.22","article-title":"Maternal Educational Level and Risk of Gestational Hypertension: The Generation R Study","volume":"22","author":"Silva","year":"2008","journal-title":"J. Hum. Hypertens"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/ijnmr.ijnmr_451_20","article-title":"Association between Socioeconomic Status and Homeostasis Model Assessment-Insulin Resistance Index and Mediating Variables at the First Trimester of Pregnancy","volume":"27","author":"Mohammadi","year":"2022","journal-title":"Iran J. Nurs. Midwifery Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/5\/1135\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:40:58Z","timestamp":1760121658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/5\/1135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["nu15051135"],"URL":"https:\/\/doi.org\/10.3390\/nu15051135","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,23]]}}}