{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:14:09Z","timestamp":1792268049738,"version":"4.4.0"},"reference-count":119,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kantonsspital Aarau","award":["1410.000.058"],"award-info":[{"award-number":["1410.000.058"]}]},{"name":"Kantonsspital Aarau","award":["1410.000.044"],"award-info":[{"award-number":["1410.000.044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The importance of the interplay between inflammation and nutrition has generated much interest in recent times. Inflammation has been identified as a key driver for disease-related malnutrition, leading to anorexia, reduced food intake, muscle catabolism, and insulin resistance, which are stimulating a catabolic state. Interesting recent data suggest that inflammation also modulates the response to nutritional treatment. Studies have demonstrated that patients with high inflammation show no response to nutritional interventions, while patients with lower levels of inflammation do. This may explain the contradictory results of nutritional trials to date. Several studies of heterogeneous patient populations, or in the critically ill or advanced cancer patients, have not found significant benefits on clinical outcome. Vice versa, several dietary patterns and nutrients with pro- or anti-inflammatory properties have been identified, demonstrating that nutrition influences inflammation. Within this review, we summarize and discuss recent advances in both the role of inflammation in malnutrition and the effect of nutrition on inflammation.<\/jats:p>","DOI":"10.3390\/nu15051159","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T01:59:10Z","timestamp":1677463150000},"page":"1159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":211,"title":["Inflammation and Nutrition: Friend or Foe?"],"prefix":"10.3390","volume":"15","author":[{"given":"Franziska","family":"Stumpf","sequence":"first","affiliation":[{"name":"Medical University Department of Medicine, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, 5001 Aarau, Switzerland"},{"name":"Department of Nutritional Medicine and Prevention, Institute of Clinical Nutrition, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-7848","authenticated-orcid":false,"given":"Bettina","family":"Keller","sequence":"additional","affiliation":[{"name":"Medical University Department of Medicine, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, 5001 Aarau, Switzerland"},{"name":"Medical Faculty, University of Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-6462","authenticated-orcid":false,"given":"Carla","family":"Gressies","sequence":"additional","affiliation":[{"name":"Medical University Department of Medicine, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-4949","authenticated-orcid":false,"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Medical University Department of Medicine, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, 5001 Aarau, Switzerland"},{"name":"Medical Faculty, University of Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(21)01451-3","article-title":"Management of disease-related malnutrition for patients being treated in hospital","volume":"398","author":"Schuetz","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1177\/0148607115625638","article-title":"Association Between Malnutrition and Clinical Outcomes in the Intensive Care Unit: A Systematic Review","volume":"41","author":"Lew","year":"2017","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.nut.2015.06.007","article-title":"Association of nutritional risk and adverse medical outcomes across different medical inpatient populations","volume":"31","author":"Felder","year":"2015","journal-title":"Nutrition"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jpen.1599","article-title":"Malnutrition Diagnosis in Critically Ill Patients Using 2012 Academy of Nutrition and Dietetics\/American Society for Parenteral and Enteral Nutrition Standardized Diagnostic Characteristics Is Associated With Longer Hospital and Intensive Care Unit Length of Stay and Increased In-Hospital Mortality","volume":"44","author":"Hiura","year":"2020","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1915707","DOI":"10.1001\/jamanetworkopen.2019.15707","article-title":"Nutritional Support Among Medical Inpatients-Feed the Cold (and Malnourished) and Starve the Febrile","volume":"2","author":"Marik","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_6","first-page":"Cd011598","article-title":"Nutrition support in hospitalised adults at nutritional risk","volume":"5","author":"Feinberg","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e200663","DOI":"10.1001\/jamanetworkopen.2020.0663","article-title":"Association of Baseline Inflammation With Effectiveness of Nutritional Support Among Patients With Disease-Related Malnutrition: A Secondary Analysis of a Randomized Clinical Trial","volume":"3","author":"Merker","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clnu.2016.09.004","article-title":"ESPEN guidelines on definitions and terminology of clinical nutrition","volume":"36","author":"Cederholm","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_9","first-page":"w13957","article-title":"Loss of appetite in acutely ill medical inpatients: Physiological response or therapeutic target?","volume":"144","author":"Schuetz","year":"2014","journal-title":"Swiss Med Wkly."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/0148607113512154","article-title":"Malnutrition diagnoses in hospitalized patients: United States, 2010","volume":"38","author":"Corkins","year":"2014","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0261-5614(02)00214-5","article-title":"Nutritional risk screening (NRS 2002): A new method based on an analysis of controlled clinical trials","volume":"22","author":"Kondrup","year":"2003","journal-title":"Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/014860718701100108","article-title":"What is subjective global assessment of nutritional status?","volume":"11","author":"Detsky","year":"1987","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.clnu.2004.02.003","article-title":"The development, validation and reliability of a nutrition screening tool based on the recommendations of the British Association for Parenteral and Enteral Nutrition (BAPEN)","volume":"23","author":"Weekes","year":"2004","journal-title":"Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"M366","DOI":"10.1093\/gerona\/56.6.M366","article-title":"Screening for undernutrition in geriatric practice: Developing the short-form mini-nutritional assessment (MNA-SF)","volume":"56","author":"Rubenstein","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcsm.12383","article-title":"GLIM criteria for the diagnosis of malnutrition\u2014A consensus report from the global clinical nutrition community","volume":"10","author":"Cederholm","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jand.2012.03.012","article-title":"Consensus statement of the Academy of Nutrition and Dietetics\/American Society for Parenteral and Enteral Nutrition: Characteristics recommended for the identification and documentation of adult malnutrition (undernutrition)","volume":"112","author":"White","year":"2012","journal-title":"J. Acad. Nutr. Diet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jamainternmed.2015.6587","article-title":"Nutritional Support and Outcomes in Malnourished Medical Inpatients: A Systematic Review and Meta-analysis","volume":"176","author":"Bally","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(18)32776-4","article-title":"Individualised nutritional support in medical inpatients at nutritional risk: A randomised clinical trial","volume":"393","author":"Schuetz","year":"2019","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.clnu.2015.12.010","article-title":"Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial","volume":"35","author":"Deutz","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1915138","DOI":"10.1001\/jamanetworkopen.2019.15138","article-title":"Association of Nutritional Support With Clinical Outcomes Among Medical Inpatients Who Are Malnourished or at Nutritional Risk: An Updated Systematic Review and Meta-analysis","volume":"2","author":"Gomes","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.clnesp.2021.08.003","article-title":"Nutritional trials using high protein strategies and long duration of support show strongest clinical effects on mortality.: Results of an updated systematic review and meta-analysis","volume":"45","author":"Faessli","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ajcn\/83.4.735","article-title":"Cachexia: Pathophysiology and clinical relevance","volume":"83","author":"Morley","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/bja\/aeu187","article-title":"Metabolic response to the stress of critical illness","volume":"113","author":"Preiser","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s10072-021-05810-1","article-title":"Structural and functional connections between the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and the immune system: A context and time dependent stress response network","volume":"43","author":"Mueller","year":"2022","journal-title":"Neurol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Muller, N.A., Kaegi-Braun, N., Durmisi, M., Gressies, C., Tribolet, P., Stanga, Z., Mueller, B., and Schuetz, P. (2022). Low T3 syndrome upon admission and response to nutritional support in malnourished medical inpatients. J. Clin. Endocrinol. Metab.","DOI":"10.1210\/clinem\/dgac743"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/0884533617695242","article-title":"Role of Nutrition Support in Inflammatory Conditions","volume":"32","author":"Lheureux","year":"2017","journal-title":"Nutr. Clin. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000129759","article-title":"Potential interplay between nutrition and inflammation in dialysis patients","volume":"161","author":"Kuhlmann","year":"2008","journal-title":"Contrib. Nephrol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1053\/j.jrn.2010.07.005","article-title":"Appetite-regulating hormones in chronic kidney disease patients","volume":"21","author":"Gurdol","year":"2011","journal-title":"J. Ren. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nm.2513","article-title":"Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells","volume":"17","author":"Ellingsgaard","year":"2011","journal-title":"Nat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., and Colao, A. (2022). Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction. Nutrients, 14.","DOI":"10.3390\/nu14061137"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Simonetto, M., Infante, M., Sacco, R.L., Rundek, T., and Della-Morte, D. (2019). A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia. Nutrients, 11.","DOI":"10.3390\/nu11102279"},{"key":"ref_32","first-page":"Cd003177","article-title":"Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease","volume":"3","author":"Abdelhamid","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_33","first-page":"Cd011094","article-title":"Omega-6 fats for the primary and secondary prevention of cardiovascular disease","volume":"7","author":"Hooper","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","first-page":"1579","article-title":"Nutrients Interaction with the Immune System","volume":"76","author":"Noor","year":"2021","journal-title":"Arch. Razi Inst."},{"key":"ref_35","first-page":"333","article-title":"The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review","volume":"7","author":"Poles","year":"2021","journal-title":"J. Clin. Transl. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot Essent Fat. Acids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/09637486.2015.1077790","article-title":"A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: Does the ratio really matter?","volume":"66","author":"Marventano","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1017\/S1368980013002115","article-title":"Designing and developing a literature-derived, population-based dietary inflammatory index","volume":"17","author":"Shivappa","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1096\/fj.201802445R","article-title":"Omega-3 fatty acids, cardiovascular risk, and the resolution of inflammation","volume":"33","author":"Hansson","year":"2019","journal-title":"Faseb. J."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Raad, T., Griffin, A., George, E.S., Larkin, L., Fraser, A., Kennedy, N., and Tierney, A.C. (2021). Dietary Interventions with or without Omega-3 Supplementation for the Management of Rheumatoid Arthritis: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13103506"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1038\/s41598-017-05278-0","article-title":"Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia","volume":"7","author":"Shirai","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/01635581.2018.1460678","article-title":"Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico","volume":"70","year":"2018","journal-title":"Nutr. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrendo.2009.79","article-title":"Trans fatty acids: Effects on metabolic syndrome, heart disease and diabetes","volume":"5","author":"Micha","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Venter, C., Eyerich, S., Sarin, T., and Klatt, K.C. (2020). Nutrition and the Immune System: A Complicated Tango. Nutrients, 12.","DOI":"10.3390\/nu12030818"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101596","DOI":"10.1016\/j.arr.2022.101596","article-title":"The role of nutrition in inflammaging","volume":"77","author":"Stamerra","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ojo, O., Ojo, O.O., Wang, X.H., and Adegboye, A.R.A. (2019). The Effects of a Low GI Diet on Cardiometabolic and Inflammatory Parameters in Patients with Type 2 and Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients, 11.","DOI":"10.3390\/nu11071584"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Twarda-Clapa, A., Olczak, A., Bia\u0142kowska, A.M., and Kozio\u0142kiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11.","DOI":"10.3390\/cells11081312"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3892\/br.2021.1422","article-title":"Toxicity of advanced glycation end products (Review)","volume":"14","author":"Kuzan","year":"2021","journal-title":"Biomed. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/0884533617700353","article-title":"Anti-Inflammatory Diet in Clinical Practice: A Review","volume":"32","author":"Ricker","year":"2017","journal-title":"Nutr. Clin. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e14264","DOI":"10.1111\/jfbc.14264","article-title":"Health benefits of polyphenols: A concise review","volume":"46","author":"Rana","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/bcp.12986","article-title":"Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A substudy of the PREDIMED trial","volume":"83","author":"Casas","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Pastor, R.F., Repetto, M.G., Lairion, F., Lazarowski, A., Merelli, A., Manfredi Carabetti, Z., Pastor, I., Pastor, E., Iermoli, L.V., and Bavasso, C.A. (2020). Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Nutrients, 12.","DOI":"10.3390\/nu12103149"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, X., Qi, Y., and Zheng, H. (2022). Dietary Polyphenol, Gut Microbiota, and Health Benefits. Antioxidants, 11.","DOI":"10.3390\/antiox11061212"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/nutrit\/nuaa010","article-title":"A posteriori dietary patterns and their association with systemic low-grade inflammation in adults: A systematic review and meta-analysis","volume":"79","author":"Norde","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.3945\/jn.115.228718","article-title":"Development and Validation of an Empirical Dietary Inflammatory Index","volume":"146","author":"Tabung","year":"2016","journal-title":"J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sureda, A., Bibiloni, M.D.M., Julibert, A., Bouzas, C., Argelich, E., Llompart, I., Pons, A., and Tur, J.A. (2018). Adherence to the Mediterranean Diet and Inflammatory Markers. Nutrients, 10.","DOI":"10.3390\/nu10010062"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101869","DOI":"10.1016\/j.redox.2021.101869","article-title":"Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies","volume":"42","author":"Aleksandrova","year":"2021","journal-title":"Redox. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e13024","DOI":"10.1111\/obr.13024","article-title":"Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature","volume":"21","author":"Watanabe","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jpen.2226","article-title":"Ketogenic diet and cancer: Fad or fabulous?","volume":"45","author":"Mundi","year":"2021","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/advances\/nmz007","article-title":"Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"10","author":"Ghaedi","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3945\/jn.115.224048","article-title":"Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults","volume":"146","author":"Whalen","year":"2016","journal-title":"J. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s00394-019-02000-w","article-title":"Dietary patterns associated with inflammatory biomarkers in a Northern German population","volume":"59","author":"Barbaresko","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3945\/jn.117.248377","article-title":"An Empirical Dietary Inflammatory Pattern Score Enhances Prediction of Circulating Inflammatory Biomarkers in Adults","volume":"147","author":"Tabung","year":"2017","journal-title":"J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clnesp.2022.04.019","article-title":"Effect of tomato consumption on inflammatory markers in health and disease status: A systematic review and meta-analysis of clinical trials","volume":"50","author":"Widjaja","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/bmj.327.7407.117","article-title":"Immunonutrition","volume":"327","author":"Calder","year":"2003","journal-title":"Bmj"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/01.mog.0000153360.90653.82","article-title":"Immunonutrition","volume":"21","author":"Grimble","year":"2005","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hill, A., Elke, G., and Weimann, A. (2021). Nutrition in the Intensive Care Unit-A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13082851"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jpen.1736","article-title":"Immunonutrition vs Standard Nutrition for Cancer Patients: A Systematic Review and Meta-Analysis (Part 1)","volume":"44","author":"Yu","year":"2020","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ncp.10101","article-title":"Full Nutrition or Not?","volume":"33","author":"Stuever","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"doz111","DOI":"10.1093\/dote\/doz111","article-title":"Perioperative immunonutrition in esophageal cancer patients undergoing esophagectomy: The first meta-analysis of randomized clinical trials","volume":"33","author":"Mingliang","year":"2020","journal-title":"Dis. Esophagus"},{"key":"ref_73","first-page":"Cd010954","article-title":"Immunonutrition for patients undergoing surgery for head and neck cancer","volume":"8","author":"Howes","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Yang, F.A., Chen, Y.C., and Tiong, C. (2020). Immunonutrition in Patients with Pancreatic Cancer Undergoing Surgical Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 12.","DOI":"10.3390\/nu12092798"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","article-title":"ESPEN practical guideline: Clinical Nutrition in cancer","volume":"40","author":"Muscaritoli","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.clnu.2017.02.013","article-title":"ESPEN guideline: Clinical nutrition in surgery","volume":"36","author":"Weimann","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","article-title":"ESPEN guideline on clinical nutrition in the intensive care unit","volume":"38","author":"Singer","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.clnesp.2019.05.002","article-title":"Clinical Nutrition in Critical Care Medicine\u2014Guideline of the German Society for Nutritional Medicine (DGEM)","volume":"33","author":"Elke","year":"2019","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000444096","article-title":"Unraveling the Link between Malnutrition and Adverse Clinical Outcomes: Association of Acute and Chronic Malnutrition Measures with Blood Biomarkers from Different Pathophysiological States","volume":"68","author":"Felder","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Keller, U. (2019). Nutritional Laboratory Markers in Malnutrition. J. Clin. Med., 8.","DOI":"10.3390\/jcm8060775"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1572-0241.2006.01024.x","article-title":"Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials","volume":"102","author":"Koretz","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_82","first-page":"CD003288","article-title":"Protein and energy supplementation in elderly people at risk from malnutrition","volume":"2009","author":"Milne","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.clnu.2022.04.025","article-title":"Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial","volume":"41","author":"Stalder","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.clnu.2022.02.009","article-title":"Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial","volume":"41","author":"Boesiger","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.jacc.2021.03.232","article-title":"Individualized Nutritional Support for Hospitalized Patients With Chronic Heart Failure","volume":"77","author":"Hersberger","year":"2021","journal-title":"J. Am. Coll Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.clnu.2020.10.009","article-title":"Effect of nutritional support in patients with lower respiratory tract infection: Secondary analysis of a randomized clinical trial","volume":"40","author":"Baumgartner","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.annonc.2021.05.793","article-title":"Nutritional support during the hospital stay reduces mortality in patients with different types of cancers: Secondary analysis of a prospective randomized trial","volume":"32","author":"Bargetzi","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1016\/j.clnu.2021.03.013","article-title":"Admission kidney function is a strong predictor for the response to nutritional support in patients at nutritional risk","volume":"40","author":"Bargetzi","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/jama.2013.278481","article-title":"Acute skeletal muscle wasting in critical illness","volume":"310","author":"Puthucheary","year":"2013","journal-title":"JAMA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1056\/NEJMoa1811687","article-title":"Energy-Dense versus Routine Enteral Nutrition in the Critically Ill","volume":"379","author":"Chapman","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00134-015-4131-4","article-title":"Normocaloric versus hypocaloric feeding on the outcomes of ICU patients: A systematic review and meta-analysis","volume":"42","author":"Marik","year":"2016","journal-title":"Intensive Care Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJMoa1102662","article-title":"Early versus late parenteral nutrition in critically ill adults","volume":"365","author":"Casaer","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ccm.2015.05.013","article-title":"Controversies and Misconceptions in Intensive Care Unit Nutrition","volume":"36","author":"Hooper","year":"2015","journal-title":"Clin. Chest Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1212722","article-title":"A randomized trial of glutamine and antioxidants in critically ill patients","volume":"368","author":"Heyland","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/cc11828","article-title":"Does artificial nutrition improve outcome of critical illness?","volume":"17","author":"Schetz","year":"2013","journal-title":"Crit. Care"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMra1304623","article-title":"Nutrition in the acute phase of critical illness","volume":"370","author":"Casaer","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.2012.137","article-title":"Initial trophic vs full enteral feeding in patients with acute lung injury: The EDEN randomized trial","volume":"307","author":"Rice","year":"2012","journal-title":"JAMA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJM199612193352507","article-title":"Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway","volume":"335","author":"Mitch","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.annonc.2021.08.1989","article-title":"Inflammation reduces the effect of nutritional therapy on clinical outcomes in cancer patients","volume":"32","author":"Bargetzi","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.nut.2006.04.011","article-title":"Effects of acute-phase response on nutritional status and clinical outcome of hospitalized patients","volume":"22","author":"Gariballa","year":"2006","journal-title":"Nutrition"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"101301","DOI":"10.1016\/j.eclinm.2022.101301","article-title":"Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial","volume":"45","author":"Bretschera","year":"2022","journal-title":"EClinicalMedicine"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"R684","DOI":"10.1016\/j.cub.2022.04.071","article-title":"Balancing nutrient and energy demand and supply via autophagy","volume":"32","author":"He","year":"2022","journal-title":"Curr. Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1193497","article-title":"Autophagy and metabolism","volume":"330","author":"Rabinowitz","year":"2010","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0140-6736(12)61893-5","article-title":"When should we add parenteral to enteral nutrition?","volume":"381","author":"Vincent","year":"2013","journal-title":"Lancet"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"E633","DOI":"10.1210\/jc.2010-2563","article-title":"Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients","volume":"96","author":"Vanhorebeek","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/advances\/nmy011","article-title":"Autophagy: The Last Defense against Cellular Nutritional Stress","volume":"9","author":"He","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/0148607117721908","article-title":"Controversies Surrounding Critical Care Nutrition: An Appraisal of Permissive Underfeeding, Protein, and Outcomes","volume":"42","author":"Patel","year":"2018","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Berlana, D. (2022). Parenteral Nutrition Overview. Nutrients, 14.","DOI":"10.3390\/nu14214480"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/MCC.0000000000000961","article-title":"Nutrition before, during and after critical illness","volume":"28","author":"Ridley","year":"2022","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Gressies, C., and Schuetz, P. (2023). Nutritional issues concerning general medical ward patients: Feeding patients recovering from critical illness. Curr. Opin. Clin. Nutr. Metab. Care.","DOI":"10.1097\/MCO.0000000000000894"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Elia, M., Ljungqvist, O., Stratton, R.J., Lanham-New, S.A., and Davies, S.C. (2015). Clinical Nutrition, Elsevier.","DOI":"10.1002\/9781119211945"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1164\/rccm.201605-1012OC","article-title":"Permissive Underfeeding or Standard Enteral Feeding in High- and Low-Nutritional-Risk Critically Ill Adults. Post Hoc Analysis of the PermiT Trial","volume":"195","author":"Arabi","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.nut.2004.06.003","article-title":"Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature","volume":"20","author":"Gramlich","year":"2004","journal-title":"Nutrition"},{"key":"ref_115","first-page":"S16","article-title":"Nutrition issues in the general medical ward patient: From general screening to specific diagnosis and individualized treatment","volume":"47","author":"Gressies","year":"2022","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_116","first-page":"w20112","article-title":"Evidence-based nutrition for the malnourished, hospitalised patient: One bite at a time","volume":"149","author":"Merker","year":"2019","journal-title":"Swiss Med. Wkly."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-food-032519-051736","article-title":"Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity","volume":"11","author":"Zeisel","year":"2020","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/ajcn\/nqab042","article-title":"Value of handgrip strength to predict clinical outcomes and therapeutic response in malnourished medical inpatients: Secondary analysis of a randomized controlled trial","volume":"114","author":"Tribolet","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"100092","DOI":"10.1016\/j.esmoop.2021.100092","article-title":"Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines","volume":"6","author":"Arends","year":"2021","journal-title":"ESMO Open"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/5\/1159\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:42:44Z","timestamp":1760121764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/5\/1159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,25]]},"references-count":119,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["nu15051159"],"URL":"https:\/\/doi.org\/10.3390\/nu15051159","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,25]]}}}