{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:20:28Z","timestamp":1790198428867,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","award":["451-03-68\/2022-14\/200116"],"award-info":[{"award-number":["451-03-68\/2022-14\/200116"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bee products, including honey, have been utilized since ancient times for nutritional and therapeutic purposes. Recently, other bee products such as bee pollen, royal jelly, and propolis have caught a lot of attention. Being high in antioxidants and bioactive compounds, these products have established their applications in the pharmaceutical field as supplementary or alternative medicines. This review focuses on their use against polycystic ovarian syndrome (PCOS)-related infertility. A systematic search of electronic databases including PubMed, Web of Science ScienceDirect, and Google Scholar was conducted from their inceptions up to November 2022. Studies with a small sample size, studies with inconclusive data, and pre-prints have been excluded. A narrative synthesis was performed during draft preparation after the authors independently performed a literature search. A total of 47 studies were finalized for the review. It can be observed that in vivo data on the use of bee products in treating PCOS mostly deals with their use in synergism with the PCOS medicines to enhance their effect and\/or curb their side effects; however, clinical trials for the same are limited. With the amount of data being limited, it is difficult to map out the mechanism by which these products act in managing PCOS inside the human body. The review gives detailed insights into the reversal and restorative properties of bee products against the aberrations in reproductive health caused by PCOS.<\/jats:p>","DOI":"10.3390\/nu15051165","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T01:59:10Z","timestamp":1677463150000},"page":"1165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Utilization of Bee Products as a Holistic Approach to Managing Polycystic Ovarian Syndrome-Related Infertility"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-5387","authenticated-orcid":false,"given":"Ahmad","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Life Sciences, University of Mumbai, Vidyanagari, Mumbai 400098, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Additiya","family":"Paramanya","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Mumbai, Vidyanagari, Mumbai 400098, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Poojari","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Mumbai, Vidyanagari, Mumbai 400098, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damla","family":"Arslan-Acaroz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey"},{"name":"ACR Bio Food and Biochemistry Research and Development, 03200 Afyonkarahisar, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1533-4519","authenticated-orcid":false,"given":"Ulas","family":"Acaroz","sequence":"additional","affiliation":[{"name":"ACR Bio Food and Biochemistry Research and Development, 03200 Afyonkarahisar, Turkey"},{"name":"Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey"},{"name":"Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Kyrgyz-Turkish Manas University, Bishkek KG-720038, Kyrgyzstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-4029","authenticated-orcid":false,"given":"Aleksandar \u017d.","family":"Kosti\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: Consequences, Challenges, and Guiding Treatment","volume":"106","author":"Hoeger","year":"2020","journal-title":"J. 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