{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:57:38Z","timestamp":1760147858248,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["32290093","445703531","FMC2008"],"award-info":[{"award-number":["32290093","445703531","FMC2008"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fresenius Medical Care","award":["32290093","445703531","FMC2008"],"award-info":[{"award-number":["32290093","445703531","FMC2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cardiovascular complications are accompanied by life-threatening complications and represent the major cause of death in patients with chronic kidney disease (CKD). Magnesium is important for the physiology of cardiac function, and its deficiency is common in CKD. In the present study, we investigated the impact of oral magnesium carbonate supplementation on cardiac function in an experimental model of CKD induced in Wistar rats by an adenine diet. Echocardiographic analyses revealed restoration of impaired left ventricular cardiac function in animals with CKD. Cardiac histology and real-time PCR confirmed a high amount of elastin protein and increased collagen III expression in CKD rats supplemented with dietary magnesium as compared with CKD controls. Both structural proteins are crucial in maintaining cardiac health and physiology. Aortic calcium content increased in CKD as compared with tissue from control animals. Magnesium supplementation numerically lowered the increases in aortic calcium content as it remained statistically unchanged, compared with controls. In summary, the present study provides evidence for an improvement in cardiovascular function and aortic wall integrity in a rat model of CKD by magnesium, as evidenced by echocardiography and histology.<\/jats:p>","DOI":"10.3390\/nu15061303","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:43:35Z","timestamp":1678153415000},"page":"1303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content"],"prefix":"10.3390","volume":"15","author":[{"given":"Xoana","family":"Barros","sequence":"first","affiliation":[{"name":"Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany"},{"name":"Fundaci\u00f3 Puigvert, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenia","family":"Friesen","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Mathias Brandenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Rhein-Maas Klinikum W\u00fcrselen, 52146 Wuerselen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-3272","authenticated-orcid":false,"given":"Elisa Anamaria","family":"Liehn","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark"},{"name":"\u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"National Heart Center Singapore, Singapore 169609, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Steppan","sequence":"additional","affiliation":[{"name":"Scientific Affairs, Center of Excellence Medical, Fresenius Medical Care Deutschland GmbH, 61352 Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-0399","authenticated-orcid":false,"given":"Fabian","family":"Kiessling","sequence":"additional","affiliation":[{"name":"Institute for Experimental Molecular Imaging, RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Kramann","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany"},{"name":"Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-5914","authenticated-orcid":false,"given":"Thilo","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-7660","authenticated-orcid":false,"given":"Nadine","family":"Kaesler","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany"},{"name":"Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Azem, R., Daou, R., Bassil, E., Anvari, E.M., Taliercio, J.J., Arrigain, S., Schold, J.D., Vachharajani, T., Nally, J., and Na Khoul, G.N. 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