{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:06:59Z","timestamp":1786241219448,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cornell University Center for Life Science Enterprise","award":["20210860"],"award-info":[{"award-number":["20210860"]}]},{"name":"VitaMe Technologies, Inc. (DBA VitaScan\u2122)","award":["20210860"],"award-info":[{"award-number":["20210860"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency is a public health problem with devastating health, developmental and behavioral effects which often exacerbated due to affordability and access to screening and diagnosis. Using IronScan\u2122 a portable, point-of-care diagnostic system capable of quantitatively measuring ferritin in blood, we validated IronScan\u2122 ferritin measurements using whole blood and serum with a lab-based, regulator-approved analytical device for measuring ferritin in venous serum. Capillary (finger stick) and venous whole blood samples were obtained from 44 male and female volunteers. Venous serum (vSer) ferritin concentrations were measured on Immulite 2000 Xpi (gold standard). Capillary whole blood (cWB), venous whole blood (vWB), and vSer ferritin levels were measured by IronScan\u2122. cWB ferritin concentrations from IronScan\u2122 were significantly correlated (R2 = 0.86) with vSer measured with the FDA-approved Immulite system. The results from the multiple regression analysis indicate that 10% of the variability was due to the method of blood collection (venous vs. capillary) and 6% was due to the form of blood analysis (whole blood vs. serum). The sensitivity of diagnosing iron deficiency using the WHO cutoff of &lt;30 ng\/mL is 90%, with a specificity of 96%. In conclusion, IronScan\u2122 is a rapid viable option for measuring ferritin as a point-of-care system.<\/jats:p>","DOI":"10.3390\/nu15061305","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:43:35Z","timestamp":1678153415000},"page":"1305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Using Capillary Whole Blood to Quantitatively Measure Ferritin: A Validation Trial of a Point-of-Care System"],"prefix":"10.3390","volume":"15","author":[{"given":"Joanna L.","family":"Fiddler","sequence":"first","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA"},{"name":"Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, SC 29634, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4511-6034","authenticated-orcid":false,"given":"Michael I.","family":"McBurney","sequence":"additional","affiliation":[{"name":"Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada"},{"name":"Friedman School of Nutrition Policy and Science, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jere D.","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","article-title":"Iron Deficiency and Reduced Work Capacity: A Critical Review of the Research to Determine a Causal Relationship","volume":"131","author":"Haas","year":"2001","journal-title":"J. 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