{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:07Z","timestamp":1787029207132,"version":"build-2736575974"},"reference-count":56,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2022-C-013"],"award-info":[{"award-number":["CSH-2022-C-013"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CMU111-S-30"],"award-info":[{"award-number":["CMU111-S-30"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["MOST 109-2314-B-040-009-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-040-009-MY3"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Medical University","award":["CSH-2022-C-013"],"award-info":[{"award-number":["CSH-2022-C-013"]}]},{"name":"China Medical University","award":["CMU111-S-30"],"award-info":[{"award-number":["CMU111-S-30"]}]},{"name":"China Medical University","award":["MOST 109-2314-B-040-009-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-040-009-MY3"]}]},{"name":"Ministry of Science and Technology","award":["CSH-2022-C-013"],"award-info":[{"award-number":["CSH-2022-C-013"]}]},{"name":"Ministry of Science and Technology","award":["CMU111-S-30"],"award-info":[{"award-number":["CMU111-S-30"]}]},{"name":"Ministry of Science and Technology","award":["MOST 109-2314-B-040-009-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-040-009-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oral submucous fibrosis (OSF) is a premalignant disorder and persistent activation of myofibroblasts is implicated in this pathological progression. Increasing attention has been addressed towards non-coding RNA-regulated myofibroblasts activities and the effects of phytochemicals on non-coding RNA modulation are of great importance. In the present study, we examined the anti-fibrosis property of \u03b1-mangostin, a xanthone isolated from the pericarp of mangosteen. We found that \u03b1-mangostin exhibited inhibitory potency in myofibroblast activities and expression of fibrosis markers at the concentrations that caused neglectable damage to normal cells. Apart from the downregulation of TGF-\u03b21\/Smad2 signaling, we found that \u03b1-mangostin attenuated the expression of long non-coding RNA LincROR as well. Our results demonstrated that the effects of \u03b1-mangostin on myofibroblast activation were reverted when LincROR was overexpressed. Additionally, we showed the expression of LincROR in OSF specimens was elevated and silencing of LincROR successfully attenuated myofibroblast characteristics and TGF-\u03b21\/Smad2 activation. Taken together, these findings indicated that the anti-fibrosis effects of \u03b1-mangostin merit consideration and may be due to the attenuation of LincROR.<\/jats:p>","DOI":"10.3390\/nu15061321","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T01:58:22Z","timestamp":1678240702000},"page":"1321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["\u03b1-Mangostin Inhibits the Activation of Myofibroblasts via Downregulation of Linc-ROR-Mediated TGFB1\/Smad Signaling"],"prefix":"10.3390","volume":"15","author":[{"given":"Yu-Hsien","family":"Lee","sequence":"first","affiliation":[{"name":"School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, China Medical University, Taichung 404333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-9340","authenticated-orcid":false,"given":"Shih-Chi","family":"Chao","sequence":"additional","affiliation":[{"name":"Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Medical Research and Education, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chia","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"},{"name":"Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hed.26006","article-title":"Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype","volume":"42","author":"Iocca","year":"2020","journal-title":"Head Neck"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wang, Y.-Y., Tail, Y.-H., Wang, W.-C., Chen, C.-Y., Kao, Y.-H., Chen, Y.-K., and Chen, C.-H. 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