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2020","award":["812699"],"award-info":[{"award-number":["812699"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>As life expectancy increases in many countries, the prevalence of age-related diseases also rises. Among these conditions, chronic kidney disease is predicted to become the second cause of death in some countries before the end of the century. An important problem with kidney diseases is the lack of biomarkers to detect early damage or to predict the progression to renal failure. In addition, current treatments only retard kidney disease progression, and better tools are needed. Preclinical research has shown the involvement of the activation of cellular senescence-related mechanisms in natural aging and kidney injury. Intensive research is searching for novel treatments for kidney diseases as well as for anti-aging therapies. In this sense, many experimental shreds of evidence support that treatment with vitamin D or its analogs can exert pleiotropic protective effects in kidney injury. Moreover, vitamin D deficiency has been described in patients with kidney diseases. Here, we review recent evidence about the relationship between vitamin D and kidney diseases, explaining the underlying mechanisms of the effect of vitamin D actions, with particular attention to the modulation of cellular senescence mechanisms.<\/jats:p>","DOI":"10.3390\/nu15061349","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T03:02:08Z","timestamp":1678417328000},"page":"1349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vitamin D, Cellular Senescence and Chronic Kidney Diseases: What Is Missing in the Equation?"],"prefix":"10.3390","volume":"15","author":[{"given":"Romina P.","family":"Martinelli","sequence":"first","affiliation":[{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-2359","authenticated-orcid":false,"given":"Sandra","family":"Rayego-Mateos","sequence":"additional","affiliation":[{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7912-1133","authenticated-orcid":false,"given":"Matilde","family":"Alique","sequence":"additional","affiliation":[{"name":"Ricors2040, 28029 Madrid, Spain"},{"name":"Departamento de Biolog\u00eda de Sistemas, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, 28871 Madrid, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"M\u00e1rquez-Exp\u00f3sito","sequence":"additional","affiliation":[{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-7284","authenticated-orcid":false,"given":"Lucia","family":"Tejedor-Santamaria","sequence":"additional","affiliation":[{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Ricors2040, 28029 Madrid, Spain"},{"name":"Department of Nephrology and Hypertension, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0701-3969","authenticated-orcid":false,"given":"Emilio","family":"Gonz\u00e1lez-Parra","sequence":"additional","affiliation":[{"name":"Ricors2040, 28029 Madrid, Spain"},{"name":"Department of Nephrology and Hypertension, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-6535","authenticated-orcid":false,"given":"Marta","family":"Ruiz-Ortega","sequence":"additional","affiliation":[{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/ckj\/sfab170","article-title":"RICORS2040: The need for collaborative research in chronic kidney disease","volume":"15","author":"Ortiz","year":"2021","journal-title":"Clin. 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