{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:30:45Z","timestamp":1788780645821,"version":"build-2803163510"},"reference-count":67,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Nature Science Foundation of Jiangxi Province","award":["20212BAB205027"],"award-info":[{"award-number":["20212BAB205027"]}]},{"name":"National Nature Science Foundation of Jiangxi Province","award":["YC2022\u2014s004"],"award-info":[{"award-number":["YC2022\u2014s004"]}]},{"name":"Jiangxi Provincial Postgraduate Innovation Special Fund","award":["20212BAB205027"],"award-info":[{"award-number":["20212BAB205027"]}]},{"name":"Jiangxi Provincial Postgraduate Innovation Special Fund","award":["YC2022\u2014s004"],"award-info":[{"award-number":["YC2022\u2014s004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease with many influencing factors. With the increasing role of the gut\u2013liver axis in various liver diseases, research on the prevention and treatment of NAFLD with probiotics is increasing. In the present study, a Bifidobacterium animalis subsp. strain, B. lactis SF, was isolated from the feces of healthy infants and characterized by sequencing of the 16S rDNA. A systematic probiotic evaluation was carried out, and a diet-induced mouse model was constructed to study the effect and mechanism of B. lactis SF on diet-induced NAFLD. Results show that B. lactis SF has excellent gastrointestinal fluid tolerance and intestinal colonization, and strong antibacterial and antioxidant capabilities. In vivo, B. lactis SF modulated intestinal flora, restored the intestinal barrier, and inhibited LPS entrance into the portal circulation, which subsequently inhibited the TLR4\/NF-\u03baB and modulated the PI3K-Akt\/AMPK signaling pathway, attenuated the inflammatory response, and reduced lipid accumulation. In addition, B. lactis SF attenuated oxidative stress and further alleviated autophagy, resulting in an ameliorative effect on NAFLD. Therefore, our study provides a new dietary method for the treatment of NAFLD.<\/jats:p>","DOI":"10.3390\/nu15061355","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T02:31:55Z","timestamp":1678674715000},"page":"1355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Huihui","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyue","family":"Tao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyue","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangxi-OAI Joint Research Institute, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China"},{"name":"Jiangxi-OAI Joint Research Institute, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixiang","family":"Wan","sequence":"additional","affiliation":[{"name":"Jiangxi-OAI Joint Research Institute, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrgastro.2013.183","article-title":"NAFLD, NASH and liver cancer","volume":"10","author":"Michelotti","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: A tale of two \u2018Hits\u2019?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.numecd.2017.10.014","article-title":"Gut microbiome composition in lean patients with NASH is associated with liver damage independent of caloric intake: A prospective pilot study","volume":"28","author":"Duarte","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7109270","DOI":"10.1155\/2016\/7109270","article-title":"A Comprehensive Updated Review of Pharmaceutical and Nonpharmaceutical Treatment for NAFLD","volume":"2016","author":"Hossain","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s11684-018-0645-9","article-title":"Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota","volume":"12","author":"Han","year":"2018","journal-title":"Front. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00394-017-1524-x","article-title":"Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis","volume":"57","author":"Oliveira","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cld.2015.10.012","article-title":"Nonalcoholic Fatty Liver Disease and the Gut Microbiome","volume":"20","author":"Boursier","year":"2016","journal-title":"Clin. Liver Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jnutbio.2010.10.002","article-title":"Probiotics as an emerging therapeutic strategy to treat NAFLD: Focus on molecular and biochemical mechanisms","volume":"22","author":"Iacono","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1007\/s00253-019-09703-4","article-title":"Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK\/Nrf2 pathway","volume":"103","author":"Zhao","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_12","first-page":"2822","article-title":"Effects of Probiotics V9 on liver function, oxidative stress and lipid metabolism in rats with NAFLD induced by high fat diet and its mechanism","volume":"35","author":"Li","year":"2019","journal-title":"Chin. J. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1017\/S0007114517000204","article-title":"Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: A pilot, randomised, double-blind, placebo-controlled, clinical trial","volume":"117","author":"Mofidi","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/2049-632X.12131","article-title":"Evidence of immunomodulatory effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486","volume":"70","author":"You","year":"2014","journal-title":"Pathog. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s11033-011-0920-1","article-title":"Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum alleviates age-inflicted oxidative stress and improves expression of biomarkers of ageing in mice","volume":"39","author":"Kaushal","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1348-0421.2011.00398.x","article-title":"Anti-inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants","volume":"56","author":"Khokhlova","year":"2012","journal-title":"Microbiol. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jff.2011.02.003","article-title":"Role and classification of cholesterol-lowering functional foods","volume":"3","author":"Chen","year":"2011","journal-title":"J. Funct. Foods"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s12272-001-1180-y","article-title":"Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212","volume":"31","author":"Kim","year":"2008","journal-title":"Arch. Pharmacal Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"108703","DOI":"10.1016\/j.lwt.2019.108703","article-title":"Effects of prebiotic carbohydrates on the growth promotion and cholesterol-lowering abilities of compound probiotics in vitro","volume":"118","author":"Kuerman","year":"2020","journal-title":"LWT"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.3168\/jds.2014-9153","article-title":"In vitro probiotic characteristics of Lactobacillus plantarum ZDY 2013 and its modulatory effect on gut microbiota of mice","volume":"98","author":"Huang","year":"2015","journal-title":"J. Dairy Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/1750-3841.12079","article-title":"Safety Assessment and Probiotic Evaluation of Enterococcus Faecium YF5 Isolated from Sourdough","volume":"78","author":"Tan","year":"2013","journal-title":"J. Food Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ren, Z.Y., Huo, Y.L., Zhang, Q.M., Chen, S.F., Lv, H.H., Peng, L.L., Wei, H., and Wan, C.X. (2021). Protective Effect of Lactiplantibacillus plantarum 1201 Combined with Galactooligosaccharide on Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Nutrients, 13.","DOI":"10.3390\/nu13124441"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4103\/0971-5916.90992","article-title":"Assessing the adhesion of putative indigenous probiotic lactobacilli to human colonic epithelial cells","volume":"134","author":"Duary","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"ref_24","first-page":"19","article-title":"Study on Adhesion Ability of Lactic Acid Bacteria to the Colonic Adenocarcinoma Cell Line HT-29","volume":"7","author":"Li","year":"2002","journal-title":"J. China Agric. Univ."},{"key":"ref_25","first-page":"492","article-title":"Preliminary study on the adhesive properties and mechanisms of three probiotic strains","volume":"19","author":"Chen","year":"2007","journal-title":"Chin. J. Microecol."},{"key":"ref_26","first-page":"88","article-title":"An in vitro study of antibacterial activity of 25 strains of probiotics from human gastrointestinal tract","volume":"18","author":"Zhao","year":"2006","journal-title":"Chin. J. Microecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"112010","DOI":"10.1016\/j.foodres.2022.112010","article-title":"Targeting the gut microbiota to investigate the mechanism of Lactiplantibacillus plantarum 1201 in negating colitis aggravated by a high-salt diet","volume":"162","author":"Chen","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1574-6968.1998.tb13226.x","article-title":"The ability of probiotic bacteria to bind to human intestinal mucus","volume":"167","author":"Kirjavainen","year":"1998","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11274-018-2410-2","article-title":"A bioluminescent test system reveals valuable antioxidant properties of lactobacillus strains from human microbiota","volume":"34","author":"Marsova","year":"2018","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_30","first-page":"108","article-title":"Biotherapy for and protection against gastrointestinal pathogenic infections via action of probiotic bacteria","volume":"5","author":"Thirabunyanon","year":"2011","journal-title":"Maejo Int. J. Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113403","DOI":"10.18632\/oncotarget.15194","article-title":"Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL\/6J mice by inhibiting de-novo lipogenesis","volume":"8","author":"Love","year":"2017","journal-title":"Oncotarget"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"118986","DOI":"10.1016\/j.lfs.2020.118986","article-title":"Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease","volume":"267","author":"Gu","year":"2021","journal-title":"Life Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2264737","DOI":"10.1155\/2021\/2264737","article-title":"Probiotics Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats via Gut Microbiota\/FXR\/FGF15 Signaling Pathway","volume":"2021","author":"Luo","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4020249","DOI":"10.1155\/2020\/4020249","article-title":"An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease","volume":"2020","author":"Pei","year":"2020","journal-title":"Biomed Res. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"117997","DOI":"10.1016\/j.lfs.2020.117997","article-title":"IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease","volume":"256","author":"Xiao","year":"2020","journal-title":"Life Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1002\/fsn3.2482","article-title":"omega 3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl-CoA carboxylase","volume":"9","author":"Zhou","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ore, A., and Akinloye, O.A. (2019). Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease. Medicina, 55.","DOI":"10.3390\/medicina55020026"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1053\/gast.2001.22470","article-title":"Enhanced survival and mucosal repair after dextran sodium sulfate\u2013induced colitis in transgenic mice that overexpress growth hormone","volume":"120","author":"Williams","year":"2001","journal-title":"Gastroenterology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.metabol.2017.03.013","article-title":"Non-alcoholic fatty liver disease: An update with special focus on the role of gut microbiota","volume":"71","author":"Doulberis","year":"2017","journal-title":"Metabolism"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/jam.14992","article-title":"The interplay between host cellular and gut microbial metabolism in NAFLD development and prevention","volume":"131","author":"Yu","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/oby.22179","article-title":"Gut Microbiota: From Microorganisms to Metabolic Organ Influencing Obesity","volume":"26","author":"Stephens","year":"2018","journal-title":"Obesity"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1038\/s41467-020-18928-1","article-title":"Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization","volume":"11","author":"Pereira","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13099-018-0281-6","article-title":"Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma","volume":"11","author":"Liu","year":"2019","journal-title":"Gut Pathog."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"G413","DOI":"10.1152\/ajpgi.00361.2016","article-title":"Gut-liver axis at the frontier of host-microbial interactions","volume":"312","author":"Brandl","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0168-8278(03)80033-8","article-title":"Insulin resistance (IR) but not reduced insulin secretion (IS) is associated to non alcoholic fatty liver disease (NAFLD)","volume":"38","author":"Angelico","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4093\/dmj.2019.0042","article-title":"Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice","volume":"44","author":"Wang","year":"2020","journal-title":"Diabetes Metab. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-13-0201","article-title":"Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance","volume":"218","author":"Asrih","year":"2013","journal-title":"J. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0006-291X(02)02083-1","article-title":"Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes","volume":"296","author":"Rondinone","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1159\/000493650","article-title":"Fisetin Protects against Hepatic Steatosis through Regulation of the Sirt1\/AMPK and Fatty Acid \u03b2-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice","volume":"49","author":"Liou","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ren, T., Zhu, J., Zhu, L., and Cheng, M. (2017). The combination of blueberry juice and probiotics ameliorate non-alcoholic steatohepatitis (NASH) by affecting SREBP-1c\/PNPLA-3 pathway via PPAR-\u03b1. Nutrients, 9.","DOI":"10.3390\/nu9030198"},{"key":"ref_54","first-page":"507","article-title":"SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease","volume":"21","author":"Kohjima","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12944-016-0358-5","article-title":"Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice","volume":"15","author":"Wang","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1042\/bst0301064","article-title":"Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase","volume":"30","author":"Hardie","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_57","first-page":"E730","article-title":"Treatment of nonalcoholic fatty liver disease: Role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1073\/pnas.0337434100","article-title":"CCAAT\/enhancer-binding protein beta is required for cycle during adipogenesis","volume":"100","author":"Tang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jhep.2004.11.040","article-title":"Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients","volume":"42","author":"Malaguarnera","year":"2005","journal-title":"J. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/CS20030285","article-title":"Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients","volume":"106","author":"Videla","year":"2004","journal-title":"Clin. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/qjmed\/hcp158","article-title":"Pathogenesis of non-alcoholic fatty liver disease","volume":"103","author":"Dowman","year":"2009","journal-title":"QJM Int. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pp.43.060192.000503","article-title":"Superoxide-dismutase and stress tolerance","volume":"43","author":"Bowler","year":"1992","journal-title":"Annu. Rev. Plant Physiol. Plant Mol. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jhazmat.2015.11.060","article-title":"Molecular mechanism of catalase activity change under sodium dodecyl sulfate-induced oxidative stress in the mouse primary hepatocytes","volume":"307","author":"Wang","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2009.11.033","article-title":"Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"469","author":"Padurariu","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Shim, B.Y., Sun, D.S., Won, H.S., Lee, M.A., Hong, S.U., Jung, J.H., Cho, H.M., and Ko, Y.H. (2016). Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2250-0"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/6\/1355\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:04Z","timestamp":1760122324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/6\/1355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":67,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["nu15061355"],"URL":"https:\/\/doi.org\/10.3390\/nu15061355","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,10]]}}}