{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:36:21Z","timestamp":1791387381549,"version":"4.3.3"},"reference-count":33,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sheba Medical Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: The aim of this study was to evaluate the macronutrient and micronutrient intake and status in youth with type 1 diabetes mellitus (T1DM) following the consumption of a low-carbohydrate diet (LCD). Research Methods and Procedures: In a prospective intervention clinical trial, adolescents with T1DM using a continuous glucose monitoring device were enrolled. Following a cooking workshop, each participant received a personalized diet regime based on LCD (50\u201380 g carbohydrate\/day). A Food Frequency Questionnaire was administered, and laboratory tests were taken before and 6 months following the intervention. Twenty participants were enrolled. Results: The median age was 17 years (15; 19), and the median diabetes duration was 10 years (8; 12). During the six-months intervention, carbohydrate intake decreased from 266 g (204; 316) to 87 g (68; 95) (p = 0.004). Energy intake, the energy percent from ultra-processed food, and fiber intake decreased (p = 0.001, p = 0.024, and p &lt; 0.0001, respectively). These changes were accompanied by declines in BMI z-score (p = 0.019) and waist-circumference percentile (p = 0.007). Improvement was observed in the median HbA1c from 8.1% (7.5; 9.4) to 7.7% (6.9; 8.2) (p = 0.021). Significant declines below the DRI were shown in median intake levels of iron, calcium, vitamin B1, and folate. Conclusions: The LCD lowered ultra-processed food consumption, BMI z-scores and the indices of central obesity. However, LCDs require close nutritional monitoring due to the possibility of nutrient deficiencies.<\/jats:p>","DOI":"10.3390\/nu15061418","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T06:53:32Z","timestamp":1678863212000},"page":"1418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Impact of a Low-Carbohydrate Diet on Micronutrient Intake and Status in Adolescents with Type 1 Diabetes"],"prefix":"10.3390","volume":"15","author":[{"given":"Neriya","family":"Levran","sequence":"first","affiliation":[{"name":"Paediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Centre, Ramat-Gan 52621, Israel"},{"name":"National Juvenile Diabetes Centre, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"},{"name":"The Institute of Biochemistry, Food Science and Nutrition, The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 5290002, Israel"},{"name":"Devision of Nutrition Unit, Chaim Sheba Medical Centre, Ramat-Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-8970","authenticated-orcid":false,"given":"Noah","family":"Levek","sequence":"additional","affiliation":[{"name":"Paediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Centre, Ramat-Gan 52621, Israel"},{"name":"National Juvenile Diabetes Centre, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruria","family":"Sher","sequence":"additional","affiliation":[{"name":"National Juvenile Diabetes Centre, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Gruber","sequence":"additional","affiliation":[{"name":"Paediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Centre, Ramat-Gan 52621, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"General Management, The Chaim Sheba Medical Centre, Tel Hashomer, Ramat-Gan 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-5065","authenticated-orcid":false,"given":"Efrat","family":"Monsonego-Ornan","sequence":"additional","affiliation":[{"name":"The Institute of Biochemistry, Food Science and Nutrition, The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Pinhas-Hamiel","sequence":"additional","affiliation":[{"name":"Paediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Centre, Ramat-Gan 52621, Israel"},{"name":"National Juvenile Diabetes Centre, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dci18-0023","article-title":"Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association","volume":"41","author":"Chiang","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/pedi.13408","article-title":"ISPAD Clinical Practice Consensus Guidelines 2022: Diabetes in Adolescence","volume":"23","author":"Gregory","year":"2022","journal-title":"Pediatr. 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