{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:59:45Z","timestamp":1760147985594,"version":"build-2065373602"},"reference-count":111,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron is a transition metal that plays a crucial role in several physiological processes. It can also exhibit toxic effects on cells, due to its role in the formation of free radicals. Iron deficiency and anemia, as well as iron overload, are the result of impaired iron metabolism, in which a number of proteins, such as hepcidin, hemojuvelin and transferrin, take part. Iron deficiency is common in individuals with renal and cardiac transplants, while iron overload is more common in patients with hepatic transplantation. The current knowledge about iron metabolism in lung graft recipients and donors is limited. The problem is even more complex when we consider the fact that iron metabolism may be also driven by certain drugs used by graft recipients and donors. In this work, we overview the available literature reports on iron turnover in the human body, with particular emphasis on transplant patients, and we also attempt to assess the drugs\u2019 impact on iron metabolism, which may be useful in perioperative treatment in transplantology.<\/jats:p>","DOI":"10.3390\/nu15061453","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T03:33:57Z","timestamp":1679024037000},"page":"1453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Link between Iron Turnover and Pharmacotherapy in Transplant Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-9865","authenticated-orcid":false,"given":"Marcin","family":"Delijewski","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38, 41-808 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Barto\u0144","sequence":"additional","affiliation":[{"name":"Independent Researcher, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-5112","authenticated-orcid":false,"given":"Beata","family":"Maksym","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38, 41-808 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-9371","authenticated-orcid":false,"given":"Natalia","family":"Pawlas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38, 41-808 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.20452\/pamw.1423","article-title":"Iron metabolism in solid-organ transplantation: How far are we from solving the mystery?","volume":"122","author":"Durlik","year":"2012","journal-title":"Pol. Arch Med. Wewn."},{"key":"ref_2","first-page":"657","article-title":"Plasma ferritin determination as a diagnostics tool","volume":"145","author":"Finch","year":"1986","journal-title":"West J. Med."},{"key":"ref_3","unstructured":"Kaushansky, K., Lichtman, M.A., Prchal, J.T., Levi, M.M., Press, O.W., Burns, L.J., and Caligiuri, M. (2015). Williams Hematology, 9e, McGraw Hill."},{"key":"ref_4","unstructured":"(2022, April 05). Fact Sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS), Available online: https:\/\/ods.od.nih.gov\/factsheets\/Iron-HealthProfessional\/."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/tri.12374","article-title":"Iron metabolism in transplantation","volume":"27","author":"Schaefer","year":"2014","journal-title":"Transpl. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1479972309354688","article-title":"Anemia post-lung transplantation: Mechanisms and approach to diagnosis","volume":"7","author":"Modrykamien","year":"2010","journal-title":"Chron. Respir. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.transproceed.2013.02.057","article-title":"Effect of preoperative iron deficiency in liver transplant recipients on length of intensive care unit stay","volume":"45","author":"Aydogan","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/ndt\/gfr410","article-title":"Hepcidin: Another culprit for complications in patients with chronic kidney disease?","volume":"26","author":"Nakanishi","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/liv.13369","article-title":"Low transferrin and high ferritin concentrations are associated with worse outcome in acute liver failure","volume":"37","author":"Anastasiou","year":"2017","journal-title":"Liver Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/hep.26570","article-title":"Liver transplantation normalizes serum hepcidin level and cures iron metabolism alterations in HFE hemochromatosis","volume":"59","author":"Philip","year":"2014","journal-title":"Hepatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5414\/CNP57327","article-title":"Cardiovascular disease risk factors in chronic renal insufficiency","volume":"57","author":"Sarnak","year":"2002","journal-title":"Clin. Nephrol."},{"key":"ref_12","first-page":"176","article-title":"Cardiovascular disease after renal transplantation","volume":"20","author":"Kasiske","year":"2000","journal-title":"Semin. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2215\/CJN.01371005","article-title":"Medical care of kidney transplant recipients after the first posttransplant year","volume":"1","author":"Djamali","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1681\/ASN.2006010027","article-title":"Posttransplantation anemia at 12 months in kidney recipients treated with mycophenolate mofetil: Risk factors and implications for mortality","volume":"17","author":"Rosas","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1600-6143.2006.01727.x","article-title":"Anemia isassociated with mortality in kidney-transplanted patients: Aprospective cohort study","volume":"7","author":"Molnar","year":"2007","journal-title":"Am. J. Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1208\/s12249-015-0316-y","article-title":"A Reaction of Aspirin with Ferrous Gluconate","volume":"16","author":"Zhang","year":"2015","journal-title":"AAPS Pharmscitech"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1172\/JCI113289","article-title":"Iron chelation as a possible mechanism for aspirin-induced malondialdehyde production by mouse liver microsomes and mitochondria","volume":"81","author":"Schwarz","year":"1988","journal-title":"J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Li, W.Y., Li, F.M., Zhou, Y.F., Wen, Z.M., Ma, J., Ya, K., and Qian, Z.M. (2016). Aspirin down regulates hepcidin by inhibiting NF-\u03baB and IL6\/JAK2\/STAT3 pathways in BV-2 microglial cells treated with lipopolysaccharide. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17121921"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuint.2015.10.014","article-title":"Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells","volume":"91","author":"Xu","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.RES.82.9.1016","article-title":"Aspirin increases ferritin synthesis in endothelial cells: A novel antioxidant pathway","volume":"82","author":"Oberle","year":"1998","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1542-4758.2012.00716.x","article-title":"Simvastatin downregulates the expression of hepcidin and erythropoietin in HepG2 cells","volume":"17","author":"Chang","year":"2013","journal-title":"Hemodial. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/j.jrn.2011.09.007","article-title":"Vitamin C affects the expression of hepcidin and erythropoietin receptor in HepG2 cells","volume":"22","author":"Chiu","year":"2012","journal-title":"J. Ren. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/ndt\/gfr318","article-title":"mTOR inhibition and erythropoiesis: Microcytosis or anaemia?","volume":"27","author":"Diekmann","year":"2012","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cmet.2012.10.001","article-title":"mTOR regulates cellular iron homeostasis through tristetraprolin","volume":"16","author":"Bayeva","year":"2012","journal-title":"Cell Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.lfs.2011.08.014","article-title":"Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats","volume":"89","author":"Kolouchova","year":"2011","journal-title":"Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.lfs.2006.11.031","article-title":"Mechanisms by which acyclovir reduces the oxidative neurotoxicity and biosynthesis of quinolinic acid","volume":"80","author":"Dairam","year":"2007","journal-title":"Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1139\/y2012-091","article-title":"d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded rats","volume":"90","author":"Kramer","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1016\/j.transproceed.2010.05.158","article-title":"Sirolimus is associated with impaired hematopoiesis in heart transplant patients? A retrospective analysis","volume":"42","author":"McDonald","year":"2010","journal-title":"Transplant. Proc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/ndt\/gfp674","article-title":"Anaemia, microcytosis and sirolimus\u2014Is iron the missing link?","volume":"25","author":"Sofroniadou","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/01.tp.0000235545.49391.1b","article-title":"Sirolimus interferes with iron homeostasis in renal transplant recipients","volume":"82","author":"Maiorano","year":"2006","journal-title":"Transplantation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1097\/01.tp.0000179106.07382.6a","article-title":"Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state","volume":"80","author":"Thaunat","year":"2005","journal-title":"Transplantation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.transproceed.2007.06.032","article-title":"Study of anemia after late introduction of everolimus in the immunosuppressive treatment of renal transplant patients","volume":"39","author":"Calvo","year":"2007","journal-title":"Transplant. Proc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.transproceed.2008.05.068","article-title":"Effects of everolimus monotherapy on hematological parameters and iron homeostasis in de novo liver transplant recipients: Preliminary results","volume":"40","author":"Masetti","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/ctr.13031","article-title":"Autoimmune hemolytic anemia in solid organ transplantation-The role of immunosuppression","volume":"31","author":"Kanellopoulou","year":"2017","journal-title":"Clin. Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1432-2277.2007.00506.x","article-title":"Rapamune Maintenance Regimen (RMR) Study Group. Incidence of anemia in sirolimus-treated renal transplant recipients: The importance of preserving renal function","volume":"20","author":"Friend","year":"2007","journal-title":"Transpl. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/ckj\/sfw040","article-title":"Post renal transplant pure red cell aplasia-is tacrolimus a culprit?","volume":"9","author":"Patil","year":"2016","journal-title":"Clin. Kidney J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1034\/j.1399-3046.2003.00042.x","article-title":"Anemia in children after transplantation: Etiology and the effect of immunosuppressive therapy on erythropoiesis","volume":"7","author":"Yorgin","year":"2003","journal-title":"Pediatr. Transplant."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0272-6386(12)81129-2","article-title":"Enalapril-associated anemia in renal transplant recipients treated for hypertension","volume":"17","author":"Vlahakos","year":"1991","journal-title":"Am. J. Kidney Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1432-2277.1992.tb01723.x","article-title":"Enalapril-induced anemia in two kidney transplant recipients","volume":"5","author":"Graafland","year":"1992","journal-title":"Transpl. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2146\/ajhp160203","article-title":"Autoimmune hemolytic anemia associated with trimethoprim-sulfamethoxazole use","volume":"74","author":"Frieder","year":"2017","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-3148.2010.01061.x","article-title":"Haemolytic anaemia and renal failure associated with antibodies to trimethoprim and sulfamethoxazole","volume":"21","author":"Arndt","year":"2011","journal-title":"Transfus. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1046\/j.1537-2995.1999.39111239.x","article-title":"Serology of antibodies to second-and third-generation cephalosporins associated with immune hemolytic anemia and\/or positive direct antiglobulin tests","volume":"39","author":"Arndt","year":"1999","journal-title":"Transfusion"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2146\/ajhp080558","article-title":"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole","volume":"67","author":"Patanwala","year":"2010","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.transproceed.2011.01.077","article-title":"Hematologic side effects of azathioprine and mycophenolate in kidney transplantation","volume":"43","author":"Habas","year":"2011","journal-title":"Transplant. Proc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/lt.20031","article-title":"Post-liver-transplant anemia: Etiology and management","volume":"10","author":"Maheshwari","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00063-007-1057-9","article-title":"Die idiopathische pulmonale H\u00e4mosiderose","volume":"102","author":"Willms","year":"2007","journal-title":"Med. Klin."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.amjmed.2013.05.002","article-title":"Amlodipine reduces cardiac iron overload in patients with thalassemia major: A pilot trial","volume":"126","author":"Fernandes","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ageing\/afl066","article-title":"Aspirin prophylaxis and the prevalence of anaemia","volume":"35","author":"Jacobs","year":"2006","journal-title":"Age Ageing"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1073\/pnas.95.8.4264","article-title":"The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae","volume":"95","author":"Berset","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ajcn\/74.2.219","article-title":"Aspirin intake and the use of serum ferritin as a measure of iron status","volume":"74","author":"Fleming","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/ajcn\/78.6.1160","article-title":"Body iron stores and their determinants in healthy postmenopausal US women","volume":"78","author":"Liu","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1744-9987.2007.00476.x","article-title":"Clinical Dialysis Meeting. Iron status and the use of non-steroidal anti-inflammatory drugs in hemodialysis patients","volume":"11","author":"Wang","year":"2007","journal-title":"Ther. Apher. Dial."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.clinbiochem.2008.05.010","article-title":"Effect of fluvastatin on serum prohepcidin levels in patients with end-stage renal disease","volume":"41","author":"Arabul","year":"2008","journal-title":"Clin. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1744-9987.2009.00783.x","article-title":"How does short-term low-dose simvastatin influence serum prohepcidin levels in patients with end-stage renal disease? A pilot study","volume":"14","author":"Li","year":"2010","journal-title":"Ther. Apher. Dial."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5414\/CNP71203","article-title":"Allopurinol-induced aplastic anemia in a patient with chronic kidney disease","volume":"71","author":"Kim","year":"2009","journal-title":"Clin. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Liu, Q., Li, S., Quan, H., and Li, J. (2014). Vitamin B12 status in metformin treated patients: Systematic review. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100379"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Rusu, I.G., Suharoschi, R., Vodnar, D.C., Pop, C.R., Socaci, S.A., Vulturar, R., Istrati, M., Moro\u0219an, I., F\u0103rca\u0219, A.C., and Kerezsi, A.D. (2020). Iron Supplementation Influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency-A Literature-Based Review. Nutrients, 12.","DOI":"10.3390\/nu12071993"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Nordberg, G., Fowler, B., Nordberg, M., and Friberg, L. (2015). Handbook on the Toxicology of Metals, Elsevier.","DOI":"10.1016\/B978-0-444-59453-2.00001-9"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10 years later","volume":"117","author":"Ganz","year":"2011","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1073\/pnas.072632499","article-title":"Severe iron deficiency anemia in transgenic mice expressing liver hepcidin","volume":"99","author":"Nicolas","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.transproceed.2015.12.023","article-title":"Absolute and Functional Iron Deficiency Is a Common Finding in Patients With Heart Failure and After Heart Transplantation","volume":"48","author":"Przybylowski","year":"2016","journal-title":"Transplant. Proc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.transproceed.2009.08.003","article-title":"Anemia prevalence and possible role of hepcidin in its pathogenesis in kidney allograft recipients","volume":"4","author":"Malyszko","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ajh.20657","article-title":"Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis","volume":"81","author":"Malyszko","year":"2006","journal-title":"Am. J. Hematol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cmet.2008.09.012","article-title":"The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin","volume":"8","author":"Silvestri","year":"2008","journal-title":"Cell Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/MOG.0b013e32831ef1f7","article-title":"Iron absorption and metabolism","volume":"25","author":"Anderson","year":"2009","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/hdi.12543","article-title":"Role of hepcidin-ferroportin axis in the pathophysiology, diagnosis, and treatment of anemia of chronic inflammation","volume":"21","author":"Langer","year":"2017","journal-title":"Hemodial. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1182\/blood.V96.13.4020","article-title":"Iron homeostasis: New tales from the crypt","volume":"96","author":"Roy","year":"2000","journal-title":"Blood"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","article-title":"Iron in infection and immunity","volume":"13","author":"Cassat","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/jn\/131.2.568S","article-title":"Iron biology in immune function, muscle metabolism and neuronal functioning","volume":"131","author":"Beard","year":"2001","journal-title":"J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0748-5514(86)80034-4","article-title":"Iron-induced peroxidative injury to isolated rat hepatic mitochondria","volume":"2","author":"Bacon","year":"1986","journal-title":"J. Free Radic. Biol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jinorgbio.2008.08.014","article-title":"Mechanistic aspects of the Fenton reaction under conditions approximated to the extracellular fluid","volume":"103","author":"Freinbichler","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e5395","DOI":"10.1097\/MD.0000000000005395","article-title":"Impact of iron deficiency anemia on the function of the immune system in children","volume":"95","author":"Hassan","year":"2016","journal-title":"Medicine"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2013-07-515957","article-title":"Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras\/RAF and nutrient-dependent mTOR signaling","volume":"123","author":"Roche","year":"2014","journal-title":"Blood"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/0976-9668.127317","article-title":"Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study","volume":"5","author":"Saha","year":"2014","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12288-009-0017-3","article-title":"Effect of iron deficiency anemia and its treatment on cell mediated immunity","volume":"25","author":"Attia","year":"2009","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/523108","article-title":"A widespread deferoxamine-mediated iron-uptake system in Vibrio vulnificus","volume":"196","author":"Kim","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00281-011-0294-4","article-title":"Metal ion acquisition in Staphylococcus aureus: Overcoming nutritional immunity","volume":"34","author":"Cassat","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/mbo3.254","article-title":"Patterns of structural and sequence variation within isotype lineages of the Neisseria meningitidis transferrin receptor system","volume":"4","author":"Adamiak","year":"2015","journal-title":"Microbiologyopen"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10534-011-9431-8","article-title":"War-Fe-re: Iron at the core of fungal virulence and host immunity","volume":"24","author":"Nevitt","year":"2011","journal-title":"Biometals"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0041-1345(02)03958-1","article-title":"Anemia following renal transplantation","volume":"35","author":"Kim","year":"2003","journal-title":"Transplant. Proc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1128\/JVI.72.4.3018-3028.1998","article-title":"Human parvovirus B19 nonstructural (NS1) protein induces apo-ptosis in erythroid lineage cells","volume":"72","author":"Moffatt","year":"1998","journal-title":"J. Virol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7326\/0003-4819-109-9-695","article-title":"Epstein-Barr virus in the bone marrow of pa-tients with aplastic anemia","volume":"109","author":"Baranski","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/ndt\/6.1.57","article-title":"Autoimmune haemolytic anaemia relatedto cyclosporin with ABO-compatible kidney donor andrecipient","volume":"6","author":"McMillan","year":"1991","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/00007691-199512000-00019","article-title":"Rapamune (Sirolimus, rapamycin): An overview and mechanism of action","volume":"17","author":"Sehgal","year":"1995","journal-title":"Ther. Drug. Monit."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1046\/j.1440-1746.2003.03089.x","article-title":"Effect of Helicobacter pylori infection and low-dose aspirin use on iron stores in the elderly","volume":"18","author":"Kaffes","year":"2003","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mehy.2016.07.015","article-title":"Changes in metabolic profile, iron and ferritin levels during the treatment of metastatic renal cancer-A new potential biomarker?","volume":"94","year":"2016","journal-title":"Med. Hypotheses"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.transproceed.2012.02.040","article-title":"Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of rapamycin","volume":"45","author":"Przybylowski","year":"2013","journal-title":"Transpl. Proc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1046\/j.1600-6135.2003.00224.x","article-title":"Anemia: A Continuing Problem Following Kidney Transplantation","volume":"3","author":"Mix","year":"2003","journal-title":"Am. J. Transplant."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ageing\/afg109","article-title":"Vitamin B12 and folate deficiency in later life","volume":"33","author":"Clarke","year":"2004","journal-title":"Age Ageing"},{"key":"ref_92","first-page":"235","article-title":"Drug-induced megaloblastic anemias","volume":"10","author":"Stebbins","year":"1973","journal-title":"Semin Hematol."},{"key":"ref_93","unstructured":"DiPiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G., and Posey, L. (2020). Pharmacotherapy: A Pathophysiologic Approach, 9e, McGraw-Hill."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/jcp.23.5.392","article-title":"A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide","volume":"23","author":"Jenkins","year":"1970","journal-title":"J. Clin. Pathol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2165\/00003495-198224060-00002","article-title":"Co-trimoxazole(Trimethoprim-sulfamethoxazole) an updated review of its antibacterial activity and clinical efficacy","volume":"24","author":"Wormser","year":"1982","journal-title":"Drugs"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.bmt.1705034","article-title":"Low-dose methotrexate for the treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation","volume":"36","author":"Huang","year":"2005","journal-title":"Bone Marrow Transplant."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrrheum.2016.175","article-title":"Mechanism of Action of Methotrexate in Rheumatoid Arthritis, and the Search for Biomarkers","volume":"12","author":"Brown","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1532-5415.2002.50083.x","article-title":"Aplastic anemia induced by phenytoin: A geriatric case with severe folic acid deficiency","volume":"50","author":"Blain","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_99","unstructured":"Hoffman, R., Benz, E.J., and Shattil, S.J. (2000). Hematology Basic Principles and Practice, Churchill Livingstone. [3rd ed.]."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/j.1875-9114.1996.tb03025.x","article-title":"Drug-induced pure red cell aplasia","volume":"16","author":"Thompson","year":"1996","journal-title":"Pharmacotherapy"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e0018","DOI":"10.1199\/tab.0018","article-title":"Purine and pyrimidine nucleotide synthesis and metabolism","volume":"1","author":"Moffatt","year":"2002","journal-title":"Arab. Book"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000353623","article-title":"Recreational nitrous oxide abuse-induced vitamin B12 deficiency in a patient presenting with hyperpigmenta-tion of the skin","volume":"5","author":"Chiang","year":"2013","journal-title":"Case Rep. Dermatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1040-8428(85)80018-4","article-title":"Current considerations of the etiology of aplastic anemia","volume":"4","author":"Gewirtz","year":"1985","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/00043426-199024000-00004","article-title":"Drug-induced aplastic anemia: Pathogenesis and clinical aspects","volume":"12","author":"Malkin","year":"1990","journal-title":"Am. J. Pediatr. Hematol. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Ajmal, A., Gessert, C.E., Johnson, B.P., Renier, C.M., and Palcher, J.A. (2013). Effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on hemoglobin levels. BMC Res. Notes, 6.","DOI":"10.1186\/1756-0500-6-443"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1528-1157.1998.tb01290.x","article-title":"Carbamazepine-Induced Release of Serotonin from Rat Hippocampus In Vitro","volume":"39","author":"Dailey","year":"1998","journal-title":"Epilepsia"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.410110312","article-title":"Carbamazepine and hematological monitoring","volume":"11","author":"Hart","year":"1982","journal-title":"Ann. Neurol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.blre.2010.06.004","article-title":"Immune hemolytic anemia associated with drug therapy","volume":"24","author":"Garratty","year":"2010","journal-title":"Blood Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: A clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJM199705083361906","article-title":"The pathophysi-ology of acquired aplastic anemia","volume":"336","author":"Young","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcmd.2008.12.005","article-title":"The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis","volume":"42","author":"Nkhoma","year":"2009","journal-title":"Blood. Cells Mol. Dis."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/6\/1453\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:57:25Z","timestamp":1760122645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/6\/1453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,17]]},"references-count":111,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["nu15061453"],"URL":"https:\/\/doi.org\/10.3390\/nu15061453","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2023,3,17]]}}}