{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:23:25Z","timestamp":1788906205043,"version":"build-2803163510"},"reference-count":82,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Healt","award":["Ricerca Corrente 2022\u20132024"],"award-info":[{"award-number":["Ricerca Corrente 2022\u20132024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronological age (CA) may not accurately reflect the health status of an individual. Rather, biological age (BA) or hypothetical underlying \u201cfunctional\u201d age has been proposed as a relevant indicator of healthy aging. Observational studies have found that decelerated biological aging or \u0394age (BA-CA) is associated with a lower risk of disease and mortality. In general, CA is associated with low-grade inflammation, a condition linked to the risk of the incidence of disease and overall cause-specific mortality, and is modulated by diet. To address the hypothesis that diet-related inflammation is associated with \u0394age, a cross-sectional analysis of data from a sub-cohort from the Moli-sani Study (2005\u20132010, Italy) was performed. The inflammatory potential of the diet was measured using the Energy-adjusted Dietary Inflammatory Index (E-DIITM) and a novel literature-based dietary inflammation score (DIS). A deep neural network approach based on circulating biomarkers was used to compute BA, and the resulting \u0394age was fit as the dependent variable. In 4510 participants (men 52.0%), the mean of CA (SD) was 55.6 y (\u00b111.6), BA 54.8 y (\u00b18.6), and \u0394age \u22120.77 (\u00b17.7). In a multivariable-adjusted analysis, an increase in E-DIITM and DIS scores led to an increase in \u0394age (\u03b2 = 0.22; 95%CI 0.05, 0.38; \u03b2 = 0.27; 95%CI 0.10, 0.44, respectively). We found interaction for DIS by sex and for E-DIITM by BMI. In conclusion, a pro-inflammatory diet is associated with accelerated biological aging, which likely leads to an increased long-term risk of inflammation-related diseases and mortality.<\/jats:p>","DOI":"10.3390\/nu15061503","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T03:15:03Z","timestamp":1679368503000},"page":"1503","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between the Inflammatory Potential of the Diet and Biological Aging: A Cross-Sectional Analysis of 4510 Adults from the Moli-Sani Study Cohort"],"prefix":"10.3390","volume":"15","author":[{"given":"Claudia F.","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"},{"name":"Population Health Research Center, National Institute of Public Health, Cuernavaca 62100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Di Castelnuovo","sequence":"additional","affiliation":[{"name":"Mediterranea Cardiocentro, 80122 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-1186","authenticated-orcid":false,"given":"Simona","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-1128","authenticated-orcid":false,"given":"Emilia","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"De Curtis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-0173","authenticated-orcid":false,"given":"Mariarosaria","family":"Persichillo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-2672","authenticated-orcid":false,"given":"James R.","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA"},{"name":"Department of Nutrition, Connecting Health Innovations LLC, Columbia, SC 29201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-3179","authenticated-orcid":false,"given":"Chiara","family":"Cerletti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Benedetta","family":"Donati","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7823-1402","authenticated-orcid":false,"given":"Giovanni","family":"de Gaetano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-5885","authenticated-orcid":false,"given":"Licia","family":"Iacoviello","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"},{"name":"Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, 21100 Varese-Como, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-4463","authenticated-orcid":false,"given":"Alessandro","family":"Gialluisi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-6552","authenticated-orcid":false,"given":"Marialaura","family":"Bonaccio","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell\u2019Elettronica, 86077 Pozzilli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of 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