{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:43:09Z","timestamp":1792039389244,"version":"4.4.0"},"reference-count":72,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Health Research Fund of the Ministry of Health and Consumption (Madrid, Spain) (Instituto de Salud Carlos III, Fondo de Investigaci\u00f3n Sanitaria)","doi-asserted-by":"publisher","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Health Research Fund of the Ministry of Health and Consumption (Madrid, Spain) (Instituto de Salud Carlos III, Fondo de Investigaci\u00f3n Sanitaria)","doi-asserted-by":"publisher","award":["PI17\/01754"],"award-info":[{"award-number":["PI17\/01754"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Health Research Fund of the Ministry of Health and Consumption (Madrid, Spain) (Instituto de Salud Carlos III, Fondo de Investigaci\u00f3n Sanitaria)","doi-asserted-by":"publisher","award":["2022-FISDU-00129"],"award-info":[{"award-number":["2022-FISDU-00129"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}]},{"name":"European Union","award":["PI17\/01754"],"award-info":[{"award-number":["PI17\/01754"]}]},{"name":"European Union","award":["2022-FISDU-00129"],"award-info":[{"award-number":["2022-FISDU-00129"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In this prospective cohort study of 434 mother\u2013infant pairs from the ECLIPSES study, we examine the association between maternal vitamin B12 status at the beginning and end of pregnancy and the neurodevelopmental outcomes of infants 40 days after birth in a pregnant population from a Mediterranean region of northern Spain. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional, and psychological data were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III (BSID-III, cognitive, language, and motor skills) were administered to the infants and several obstetrical data were recorded. In the multivariable models, medium maternal first-trimester vitamin B12 levels (312 to 408 pg\/mL, tertile 2) were associated with better neonatal performance in the motor, gross motor, language, and cognitive skills with respect to tertile 1 (&lt;312 pg\/mL). The probability of obtaining a neonatal motor, gross motor, and receptive language score &gt;75th percentile was significantly higher also in the tertile 2 group. In summary, good maternal vitamin B12 status in the early stage of pregnancy appears to be associated with better infant motor, language, and cognitive performance at 40 days postpartum.<\/jats:p>","DOI":"10.3390\/nu15061529","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T06:00:01Z","timestamp":1679464801000},"page":"1529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Maternal Vitamin B12 Status during Pregnancy and Early Infant Neurodevelopment: The ECLIPSES Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Josu\u00e9","family":"Cruz-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), 43201 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-5629","authenticated-orcid":false,"given":"Andr\u00e9s","family":"D\u00edaz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), 43201 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-9558","authenticated-orcid":false,"given":"Josefa","family":"Canals-Sans","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), 43201 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"},{"name":"Centre de Recerca en Avaluaci\u00f3 i Mesura de la Conducta (CRAMC), Department of Psychology, Universitat Rovira i Virgili, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-0975","authenticated-orcid":false,"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), 43201 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43005 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS), 08007 Barcelona, Spain"},{"name":"Collaborative Research Group on Lifestyles, Nutrition and Smoking (CENIT), IDIAP Jordi Gol, 43202 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cort\u00e9s-Albornoz, M.C., Garc\u00eda-Gu\u00e1queta, D.P., Velez-van-Meerbeke, A., and Talero-Guti\u00e9rrez, C. 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