{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:13:53Z","timestamp":1791843233341,"version":"4.3.4"},"reference-count":143,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Veteran\u2019s Administration Merit Review","award":["BX003443-01"],"award-info":[{"award-number":["BX003443-01"]}]},{"name":"Veteran\u2019s Administration Merit Review","award":["DK-108054"],"award-info":[{"award-number":["DK-108054"]}]},{"name":"Veteran\u2019s Administration Merit Review","award":["P20GM121299-01A1"],"award-info":[{"award-number":["P20GM121299-01A1"]}]},{"name":"Veteran\u2019s Administration Merit Review","award":["DK-67420"],"award-info":[{"award-number":["DK-67420"]}]},{"name":"National Institutes of Health","award":["BX003443-01"],"award-info":[{"award-number":["BX003443-01"]}]},{"name":"National Institutes of Health","award":["DK-108054"],"award-info":[{"award-number":["DK-108054"]}]},{"name":"National Institutes of Health","award":["P20GM121299-01A1"],"award-info":[{"award-number":["P20GM121299-01A1"]}]},{"name":"National Institutes of Health","award":["DK-67420"],"award-info":[{"award-number":["DK-67420"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic alcohol use has been attributed to the development of malnutrition. This is in part due to the inhibitory effect of ethanol on the absorption of vital nutrients, including glucose, amino acids, lipids, water, vitamins, and minerals within the small intestine. Recent advances in research, along with new cutting-edge technologies, have advanced our understanding of the mechanism of ethanol\u2019s effect on intestinal nutrient absorption at the brush border membrane (BBM) of the small intestine. However, further studies are needed to delineate how ethanol consumption could have an impact on altered nutrient absorption under various disease conditions. Current research has elucidated the relationship of alcohol consumption on glucose, glutamine, vitamins B1 (thiamine), B2 (riboflavin), B9 (folate), C (ascorbic acid), selenium, iron, and zinc absorption within the small intestine. We conducted systematic computerized searches in PubMed using the following keywords: (1) \u201cAlcohol effects on nutrient transport\u201d; (2) \u201cAlcohol mediated malabsorption of nutrients\u201d; (3) \u201cAlcohol effects on small intestinal nutrient transport\u201d; and (4) \u201cAlcohol mediated malabsorption of nutrients in small intestine\u201d. We included the relevant studies in this review. The main objective of this review is to marshal and analyze previously published research articles and discuss, in-depth, the understanding of ethanol\u2019s effect in modulating absorption of vital macro and micronutrients in health and disease conditions. This could ultimately provide great insights in the development of new therapeutic strategies to combat malnutrition associated with alcohol consumption.<\/jats:p>","DOI":"10.3390\/nu15071571","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T03:16:46Z","timestamp":1679627806000},"page":"1571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["The Influence of Alcohol Consumption on Intestinal Nutrient Absorption: A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Molly","family":"Butts","sequence":"first","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Lakshmi","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Murughiyan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-1279","authenticated-orcid":false,"given":"Alip","family":"Borthakur","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-9942","authenticated-orcid":false,"given":"Soudamani","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1521-6918(03)00034-9","article-title":"Effect of alcohol consumption on the gut","volume":"17","author":"Bode","year":"2003","journal-title":"Best Pract. 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