{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:35:58Z","timestamp":1784396158755,"version":"3.55.0"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gobierno de Extremadura-Fondo Europeo de Desarrollo Regional","award":["GR21079"],"award-info":[{"award-number":["GR21079"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are two medical conditions in which pain, fatigue, immune\/inflammatory dysregulation, as well as various mental health disorders predominate in the diagnosis, without evidence of a clear consensus on the treatment of FM and CFS. The main aim of this research was to analyse the possible effects of a synbiotic (Synbiotic, Gasteel Plus\u00ae (Heel Espa\u00f1a S.A.U.), through the study of pro-inflammatory\/anti-inflammatory cytokines (IL-8\/IL-10) and neuroendocrine biomarkers (cortisol and DHEA), in order to evaluate the interaction between inflammatory and stress responses mediated by the cytokine-HPA (hypothalamic-pituitary-adrenal) axis, as well as mental and physical health using body composition analysis, accelerometry and previously validated questionnaires. The participants were women diagnosed with FM with or without a diagnostic of CFS. Each participant was evaluated at baseline and after the intervention, which lasted one month. Synbiotic intervention decreased levels of perceived stress, anxiety and depression, as well as improved quality of life during daily activities. In addition, the synbiotic generated an activation of HPA axis (physiological cortisol release) that can compensate the increased inflammatory status (elevated IL-8) observed at baseline in FM patients. There were no detrimental changes in body composition or sleep parameters, as well as in the most of the activity\/sedentarism-related parameters studied by accelerometry. It is concluded that synbiotic nutritional supplements can improve the dysregulated immunoneuroendocrine interaction involving inflammatory and stress responses in women diagnosed with FM, particularly in those without a previous CFS diagnostic; as well as their perceived of levels stress, anxiety, depression and quality of life.<\/jats:p>","DOI":"10.3390\/nu15071591","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:38:36Z","timestamp":1679881116000},"page":"1591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synbiotic Supplementation Improves Quality of Life and Inmunoneuroendocrine Response in Patients with Fibromyalgia: Influence of Codiagnosis with Chronic Fatigue Syndrome"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9709-4714","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Hinchado","sequence":"first","affiliation":[{"name":"Immunophyisiology Research Group, Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 06080 Badajoz, Spain"},{"name":"Immunophysiology Research Group, Physiology Department, Faculty of Sciences, University of Extremadura, 06071 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-9486","authenticated-orcid":false,"given":"Carmen Daniela","family":"Quero-Calero","sequence":"additional","affiliation":[{"name":"Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Murcia, Spain"},{"name":"International Chair of Sports Medicine, UCAM Universidad Catolica San Antonio de Murcia, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-5114","authenticated-orcid":false,"given":"Eduardo","family":"Otero","sequence":"additional","affiliation":[{"name":"Immunophyisiology Research Group, Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 06080 Badajoz, Spain"},{"name":"Immunophysiology Research Group, Physiology Department, Faculty of Sciences, University of Extremadura, 06071 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-4507","authenticated-orcid":false,"given":"Isabel","family":"G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Immunophyisiology Research Group, Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 06080 Badajoz, Spain"},{"name":"Immunophysiology Research Group, Nursing Department, Faculty of Medicine and Health Sciences, University of Extremadura, 06071 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7007-7615","authenticated-orcid":false,"given":"Eduardo","family":"Ortega","sequence":"additional","affiliation":[{"name":"Immunophyisiology Research Group, Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 06080 Badajoz, Spain"},{"name":"Immunophysiology Research Group, Physiology Department, Faculty of Sciences, University of Extremadura, 06071 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"ref_1","first-page":"159","article-title":"Evidencias Para La Prescripci\u00f3n de Ejercicio F\u00edsico En Pacientes Con Fibromialgia","volume":"3","author":"Galiano","year":"2010","journal-title":"Rev. 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