{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:48:23Z","timestamp":1788306503048,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qatar university Internal Grant","award":["QUST-1-CHS-2023-880"],"award-info":[{"award-number":["QUST-1-CHS-2023-880"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diabetes mellitus is a worldwide public health issue with numerous complications. Several risk factors are associated with diabetes, mainly due to patients following an unhealthy lifestyle. Copper is a crucial trace element, with various physiological actions. Different intake levels of copper might contribute to diabetes development due to its dual action as both an anti- and pro-oxidant. Aim: Due to the inconclusive findings regarding the relationship between copper consumption and the management of diabetes, we decided to conduct this extensive systematic review. Up to this date, no similar study has been available in the literature. In this review, we used the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Relevant articles were identified by searching the electronic databases CINAHL, EMBASE and Medline from their respective index dates to September 2022 using keywords such as \u201cCopper Intake\u201d and \u201cType 2 Diabetes\u201d. Any paper that has investigated copper exposure through supplementation or any other method that indicates copper intake in human subjects with type 2 diabetes and measures at least one of the outcomes of interest related to diabetes was included in this review. This review is comprised of 4 cross-sectional studies, 3 cohort studies, 2 RCTs, and 2 interventional studies. Two cohort studies found positive associations between copper intake and the risk of developing T2DM, while no significant association was found in the third study. Regarding diabetes outcomes in the four cross-sectional studies, two found inverse associations, one found a positive relationship, and one found no significant association. In interventional studies, all studies found a protective effect of copper, including the RCT, while one found no significant association. The results are inconsistent concerning the association between copper consumption and the likelihood of developing diabetes are inconsistent. Individuals should receive an adequate dietary amount of copper that is within the RDA levels (900 \u00b5g\/day) to avoid copper deficiency or toxicity. Further studies, especially RCTs, are strongly needed to enable researchers to elucidate more robust conclusions regarding this association.<\/jats:p>","DOI":"10.3390\/nu15071655","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T04:00:54Z","timestamp":1680062454000},"page":"1655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Role of Copper Intake in the Development and Management of Type 2 Diabetes: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Sereen","family":"Eljazzar","sequence":"first","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haya","family":"Abu-Hijleh","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Alkhatib","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sokary","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrooq","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-1693","authenticated-orcid":false,"given":"Ghadir Fakhri","family":"Al-Jayyousi","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Tayyem","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","unstructured":"Sapra, A., Bhandari, P., and Hughes, A.W. (2021). Diabetes Mellitus (Nursing), StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5001\/omj.2017.34","article-title":"Diabetes mellitus: A local and global public health emergency!","volume":"32","year":"2017","journal-title":"Oman Med. J."},{"key":"ref_3","unstructured":"(2022, December 05). Diabetes. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"04040","DOI":"10.7189\/jogh.11.04040","article-title":"Diabetes comorbidities in low-and middle-income countries: An umbrella review","volume":"11","author":"Lam","year":"2021","journal-title":"J. Glob. 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