{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:25:15Z","timestamp":1787239515227,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to a higher risk of fractures. Elderly and CKD patients have the same risk factors for protein-energy wasting, sarcopenia, and osteoporosis. Here, we investigated the association between phase angle (PhA) and bone mineral density (BMD) in dialysis-na\u00efve patients with CKD stage 5 (CKD5) and identified a statistical relationship between PhA and age, which affects bone density. Methods: Bio-impedance spectroscopy for evaluating body composition and PhA and dual-energy X-ray absorptiometry for determining the BMD were simultaneously performed in 167 consecutive patients (mean age, 59.65 \u00b1 13.98 years; women, 40.1%). Two-way analysis of variance (ANOVA) was conducted to assess the potential interaction effect of PhA and age on femoral neck BMD (FN-BMD). Results: Our results showed that PhA and age were independently associated with FN-BMD and T-score in multiple linear regressions analyses. A significant interaction effect of PhA and age on FN-BMD was found on two-way ANOVA (p = 0.028). The average BMD values for the first and second tertiles of the PhA were higher in the young versus elderly group, whereas patients in the elderly group had higher BMD in the third tertiles. Conclusions: A relationship was noted between PhA and BMD in patients with advanced-stage CKD. The effect of PhA level on FN-BMD differed between elderly and young patients. Our study suggested that higher PhA levels could be a marker explaining the maintenance of good bone health in elderly patients with CKD5. Further longitudinal analyses are needed to determine whether PhA predicts the risk of CKD-MBD-related fractures during CKD progression.<\/jats:p>","DOI":"10.3390\/nu15071680","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T03:17:35Z","timestamp":1680146255000},"page":"1680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-2993","authenticated-orcid":false,"given":"Byoung-Geun","family":"Han","sequence":"first","affiliation":[{"name":"Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daewoo","family":"Pak","sequence":"additional","affiliation":[{"name":"Division of Data Science, Yonsei University, Wonju 26493, Kang-won, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-4190","authenticated-orcid":false,"given":"Jun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-5865","authenticated-orcid":false,"given":"Jae-Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongyup","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2215\/CJN.09500916","article-title":"Fractures in Patients with CKD: Time for Action","volume":"11","author":"Moe","year":"2016","journal-title":"Clin. 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