{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:01:29Z","timestamp":1760148089332,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007109","name":"University of Ferrara","doi-asserted-by":"publisher","award":["Local funding"],"award-info":[{"award-number":["Local funding"]}],"id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Convolvulus pluricaulis (CP) is a common Indian herb, largely employed in Ayurvedic medicine and known for its neuroprotective and neuroinflammatory action. Its effectiveness against several pathologic\/sub-pathologic conditions is widely accepted, but it is not yet completely chemically characterized. In recent years, several researchers have pointed out the involvement of CP and other Convolvulaceae in lipidic and glucidic metabolism, particularly in the control of hyperlipidaemia and diabetic conditions. In this scenario, the aim of the study was to chemically characterize the medium polarity part of the CP whole plant and its fractions and to shed light on their biological activity in adipocyte differentiation using the 3T3-L1 cell model. Our results demonstrated that the CP extract and fractions could upregulate the adipocyte differentiation through the modulation of the nuclear receptor PPAR\u03b3 (Peroxisome Proliferator-Activated Receptor \u03b3), broadly recognized as a key regulator of adipocyte differentiation, and the glucose transporter GLUT-4, which is fundamental for cellular glucose uptake and for metabolism control. CP also showed the ability to exert an anti-inflammatory effect, downregulating cytokines such as Rantes, MCP-1, KC, eotaxin, and GM-CSF, which are deeply involved in insulin resistance and glucose intolerance. Taken together, these data suggest that CP could exert a potential beneficial effect on glycemia and could be employed as an anti-diabetic adjuvant or, in any case, a means to better control glucose homeostasis.<\/jats:p>","DOI":"10.3390\/nu15071727","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T10:19:33Z","timestamp":1680257973000},"page":"1727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Convolvulus pluricaulis Choisy\u2019s Extraction, Chemical Characterization and Evaluation of the Potential Effects on Glycaemic Balance in a 3T3-L1 Adipocyte Cell Model"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-0824","authenticated-orcid":false,"given":"Elisabetta","family":"Melloni","sequence":"first","affiliation":[{"name":"Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Grassilli","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-6178","authenticated-orcid":false,"given":"Arianna","family":"Romani","sequence":"additional","affiliation":[{"name":"Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-2513","authenticated-orcid":false,"given":"Erika","family":"Rimondi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-618X","authenticated-orcid":false,"given":"Annalisa","family":"Marcuzzi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Zauli","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Secchiero","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Paganetto","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Biotechnology (SVeB), UR7 Terra&Acqua Tech, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-3938","authenticated-orcid":false,"given":"Alessandra","family":"Guerrini","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Biotechnology (SVeB), UR7 Terra&Acqua Tech, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-1477","authenticated-orcid":false,"given":"Gianni","family":"Sacchetti","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Biotechnology (SVeB), UR7 Terra&Acqua Tech, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-355X","authenticated-orcid":false,"given":"Massimo","family":"Tacchini","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Biotechnology (SVeB), UR7 Terra&Acqua Tech, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S2221-1691(14)60240-9","article-title":"An update on Ayurvedic herb Convolvulus pluricaulis Choisy","volume":"4","author":"Agarwa","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.biopha.2018.11.046","article-title":"Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat","volume":"109","author":"Gupta","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112393","DOI":"10.1016\/j.jep.2019.112393","article-title":"Neuroprotective effect of Convolvulus pluricaulis Choisy in oxidative stress model of cerebral ischemia reperfusion injury and assessment of MAP2 in rats","volume":"249","author":"Shalavadi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mehla, J., Gupta, P., Pahuja, M., Diwan, D., and Diksha, D. (2020). Indian Medicinal Herbs and Formulations for Alzheimer\u2019s Disease, from Traditional Knowledge to Scientific Assessment. Brain Sci., 10.","DOI":"10.3390\/brainsci10120964"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2174\/1871527320666210920120612","article-title":"Phytotherapeutics Against Alzheimer\u2019s Disease: Mechanism, Molecular Targets and Challenges for Drug Development","volume":"21","author":"Gayathri","year":"2022","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jaim.2020.06.011","article-title":"Protective role of Convolvulus pluricaulis on lipid abnormalities in high-fat diet with low dose streptozotocin-induced experimental rat model","volume":"11","author":"Garg","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1111\/jphp.13004","article-title":"Pharmacological evaluation of Convolvulus pluricaulis as hypolipidaemic agent in Triton WR-1339-induced hyperlipidaemia in rats","volume":"70","author":"Garg","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/0748233712469653","article-title":"Phytochemical analysis of Convolvulus hystrix Vahl and its biological effects in rats","volume":"31","author":"Rezq","year":"2015","journal-title":"Toxicol. Ind. Health."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pop.2012.11.003","article-title":"Hyperlipidemia as a risk factor for cardiovascular disease","volume":"40","author":"Nelson","year":"2013","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/0974-8520.93908","article-title":"A pilot study to clinically evaluate the role of herbomineral compound \u201cRakatchap Har\u201d in the management of essential hypertension","volume":"32","author":"Nandha","year":"2011","journal-title":"Ayu"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12944-019-1120-6","article-title":"Fatty acids, epigenetic mechanisms and chronic diseases: A systematic review","volume":"18","author":"Milagro","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mrfmmm.2009.09.009","article-title":"Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components","volume":"690","author":"Martin","year":"2010","journal-title":"Mutat. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1210\/jc.2006-1268","article-title":"Peroxisome proliferator-activated receptor \u03b3 and adipose tissue\u2013understanding obesity-related changes in regulation of lipid and glucose metabolism","volume":"92","author":"Sharma","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2741\/2802","article-title":"Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists","volume":"13","author":"Kapadia","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmech.2019.01.067","article-title":"Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications","volume":"166","author":"Mirza","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113535","DOI":"10.1016\/j.ejmech.2021.113535","article-title":"Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview","volume":"221","author":"Ferri","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111095","DOI":"10.1016\/j.mce.2020.111095","article-title":"Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: A hypothetical therapeutic for cytokine storm in COVID-19?","volume":"520","author":"Garcia","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.3390\/nu7064851","article-title":"\u03b3-Oryzanol Enhances Adipocyte Differentiation and Glucose Uptake","volume":"7","author":"Jung","year":"2015","journal-title":"Nutrients"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1073\/pnas.0306743102","article-title":"Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance","volume":"102","author":"Jones","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E287","DOI":"10.1152\/ajpendo.00440.2004","article-title":"PPARgamma-mediated insulin sensitization: The importance of fat versus muscle","volume":"288","author":"Kintscher","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/pro.2858","article-title":"GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters","volume":"25","author":"Deng","year":"2016","journal-title":"Protein Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mam.2012.07.001","article-title":"The SLC2 (GLUT) family of membrane transporters","volume":"34","author":"Mueckler","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/JEP.S267912","article-title":"Hypoglycemic Activity of Curcuma mangga Val. Extract via Modulation of GLUT4 and PPAR-\u03b3 mRNA Expression in 3T3-L1 Adipocytes","volume":"12","author":"Pujimulyani","year":"2020","journal-title":"J. Exp. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"668193","DOI":"10.3389\/fendo.2021.668193","article-title":"Metabolic Consequences of Neuronal HIF1\u03b1-Deficiency in Mediobasal Hypothalamus in Mice","volume":"12","author":"Rozjan","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E392","DOI":"10.1152\/ajpendo.00126.2021","article-title":"Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats","volume":"321","author":"Ruze","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/ptr.7387","article-title":"A novel DPP-4 inhibitor Gramcyclin A attenuates cognitive deficits in APP\/PS1\/tau triple transgenic mice via enhancing brain GLP-1-dependent glucose uptake","volume":"36","author":"Li","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2337\/db16-0917","article-title":"Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation","volume":"66","author":"Reno","year":"2017","journal-title":"Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1475-2840-11-100","article-title":"GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome","volume":"11","author":"Leguisamo","year":"2012","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6828230","DOI":"10.1155\/2023\/6828230","article-title":"Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K\/AkT Signaling Pathway","volume":"2023","author":"Hadrich","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"116060","DOI":"10.1016\/j.jep.2022.116060","article-title":"Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation","volume":"306","author":"Huang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","first-page":"19","article-title":"In-Vitro Evaluation of Ethanolic Extract of Convolvulus pluricaulis Choisy for AntiInflammation & Memory Enhancing Activity","volume":"13","author":"Yadav","year":"2022","journal-title":"Int. J. Pharm. Life Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1874205X01408010011","article-title":"Neuropharmacological Profile of Extracts of Aerial Parts of Convolvulus pluricaulis Choisy in Mice Model","volume":"8","author":"Siddiqui","year":"2011","journal-title":"Open Neurol. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/WNR.0000000000001446","article-title":"Convolvulus pluricaulis extract can modulate synaptic plasticity in rat brain hippocampus","volume":"31","author":"Das","year":"2020","journal-title":"Neuroreport"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/chromsci\/bmz075","article-title":"Development and Validation of a Novel, Rapid Gradient HPLC Method for Simultaneous Estimation of Bioactive Marker Compounds in a Mixture of Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri Extracts","volume":"57","author":"Choudhary","year":"2020","journal-title":"J. Chromatogr. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1365\/s10337-008-0706-3","article-title":"Extraction of Quinolizidine Alkaloids in Non Aqueous Basic Conditions: The Case of Spartium Junceum Flowers","volume":"68","author":"Belsito","year":"2008","journal-title":"Chromatographia"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Guerrini, A., Sacchetti, G., Guevara, M.P.E., Paganetto, G., Grandini, A., Maresca, I., Menghini, L., Di Martino, L., Marengo, A., and Tacchini, M. (2021). Wild Italian Hyssopus officinalis subsp. aristatus (Godr.) Nyman: From Morphological and Phytochemical Evidences to Biological Activities. Plants, 10.","DOI":"10.3390\/plants10040631"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nut.2012.07.013","article-title":"Release of a specific set of proinflammatory adipokines by differentiating 3T3-L1 cells","volume":"29","author":"Melloni","year":"2013","journal-title":"Nutrition"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/jc.2013-4193","article-title":"Inverse correlation between circulating levels of TNF-related apoptosis-inducing ligand and 17\u03b2-estradiol","volume":"99","author":"Zauli","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","first-page":"19","article-title":"Review on ethnomedicinal uses and phytopharmacology of memory boosting herb Convolvulus pluricaulis Choisy","volume":"22","author":"Sethiya","year":"2010","journal-title":"Aust. J. Herb. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jtcme.2017.11.002","article-title":"Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis","volume":"8","author":"Rachitha","year":"2018","journal-title":"Tradit. Complement. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Elmazar, M.M., El-Abhar, H.S., Schaalan, M.F., and Farag, N.A. (2013). Phytol\/Phytanic acid and insulin resistance: Potential role of phytanic acid proven by docking simulation and modulation of biochemical alterations. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0045638"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Jayaraman, S., Devarajan, N., Rajagopal, P., Babu, S., Ganesan, S.K., Veeraraghavan, V.P., Palanisamy, C.P., Cui, B., Periyasamy, V., and Chandrasekar, K. (2021). \u03b2-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKK\u03b2\/NF-\u03baB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats. Molecules, 26.","DOI":"10.3390\/molecules26072101"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Indu, S., Vijayalakshmi, P., Selvaraj, J., and Rajalakshmi, M. (2021). Novel Triterpenoids from Cassia fistula Stem Bark Depreciates STZ-Induced Detrimental Changes in IRS-1\/Akt-Mediated Insulin Signaling Mechanisms in Type-1 Diabetic Rats. Molecules, 26.","DOI":"10.3390\/molecules26226812"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1016\/j.bmcl.2009.05.034","article-title":"Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity","volume":"19","author":"Reddy","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biopha.2017.07.112","article-title":"Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats","volume":"94","author":"Khanra","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.phymed.2012.10.011","article-title":"Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3\u03b2-taraxerol of Mangifera indica","volume":"20","author":"Sangeetha","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/np900588q","article-title":"Homoisoflavonoids from the fibrous roots of Polygonatum odoratum with glucose uptake-stimulatory activity in 3T3-L1 adipocytes","volume":"73","author":"Zhang","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijbiomac.2018.10.206","article-title":"A new chromanone isolated from Portulaca oleracea L. increases glucose uptake by stimulating GLUT4 translocation to the plasma membrane in 3T3-L1 adipocytes","volume":"123","author":"Park","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1210\/endo.142.3.8037","article-title":"Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues","volume":"142","author":"Way","year":"2001","journal-title":"Endocrinology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/gt.2010.41","article-title":"PPARgamma is essential for protection against nonalcoholic steatohepatitis","volume":"17","author":"Wu","year":"2010","journal-title":"Gene Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2217\/fca.10.86","article-title":"Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular disease","volume":"6","author":"Azhar","year":"2010","journal-title":"Future Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"G330","DOI":"10.1152\/ajpgi.00329.2013","article-title":"RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice","volume":"307","author":"Pais","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/1076029612467845","article-title":"Elevated RANTES level is associated with metabolic syndrome and correlated with activated platelets associated markers in healthy younger men","volume":"20","author":"Ueba","year":"2014","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1684\/ecn.2014.0355","article-title":"Increased circulating RANTES in type 2 diabetes","volume":"25","author":"Dworacka","year":"2014","journal-title":"Eur. Cytokine Netw."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1073\/pnas.1133870100","article-title":"Monocyte chemoattractant protein 1 in obesity and insulin resistance","volume":"100","author":"Sartipy","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"20692","DOI":"10.1074\/jbc.M109.018556","article-title":"Keratinocyte-derived chemokine in obesity: Expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis","volume":"284","author":"Neels","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e062188","DOI":"10.1136\/bmjopen-2022-062188","article-title":"Low-grade inflammation in type 2 diabetes: A cross-sectional study from a Danish diabetes outpatient clinic","volume":"12","author":"Okdahl","year":"2022","journal-title":"BMJ Open"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Balogh, A., Milib\u00e1k, T., Szab\u00f3, V., Nagy, Z.Z., Kaarniranta, K., and Resch, M.D. (2020). Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment. BMC Ophthalmol., 20.","DOI":"10.1186\/s12886-020-01745-x"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.18240\/ijo.2022.11.02","article-title":"Comprehensive assessment of growth factors, inflammatory mediators, and cytokines in vitreous from patients with proliferative diabetic retinopathy","volume":"15","author":"Gong","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Mason, R.H., Minaker, S.A., Luna, G.L., Bapat, P., Farahvash, A., Garg, A., Bhambra, N., and Muni, R.H. (2022). Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: A systematic review and meta-analysis. Eye.","DOI":"10.1038\/s41433-022-02127-x"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3177\/jnsv.68.420","article-title":"25-Hydroxyvitamin D Increases Insulin-Stimulated Glucose Uptake by Enhancing Adipocyte Differentiation","volume":"68","author":"Nakashima","year":"2022","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e2122382119","DOI":"10.1073\/pnas.2122382119","article-title":"Autocrine FGF1 signaling promotes glucose uptake in adipocytes","volume":"119","author":"Nies","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"114360","DOI":"10.1016\/j.jep.2021.114360","article-title":"Ameliorating effect on glycolipid metabolism and chemical profile of Millettia speciosa champ. extract","volume":"279","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"31372","DOI":"10.1074\/jbc.271.49.31372","article-title":"Expression of a constitutively active Akt Ser\/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation","volume":"271","author":"Kohn","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40529-021-00315-8","article-title":"Extract of white sweet potato tuber against TNF-\u03b1-induced insulin resistance by activating the PI3K\/Akt pathway in C2C12 myotubes","volume":"62","author":"Shyur","year":"2021","journal-title":"Bot. Stud."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/7\/1727\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:45Z","timestamp":1760123265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/7\/1727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":66,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["nu15071727"],"URL":"https:\/\/doi.org\/10.3390\/nu15071727","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2023,3,31]]}}}