{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:57:51Z","timestamp":1789761471677,"version":"4.0.1"},"reference-count":97,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Quercetin is a naturally existing plant pigment belonging to the flavonoid group; it is contained in a wide range of vegetables and fruits. The accumulated evidence points to the potential uses of quercetin in protection of some disease conditions. Lead is one of the highly toxicant heavy metals that are widely spread in the environment and implicated in a wide spectrum of industries. No previous study has been reported to evaluate the effect of quercetin on lead toxicity. Therefore, the present study was conducted to elucidate some aspects of quercetin bioactivities in regard to its ability to combat the oxidative stress induced by lead toxicity. For this purpose, a total of sixty male Wistar rats were randomly and equally divided into three groups of 20 animals each; untreated control animals (group 1), lead-exposed animals (group 2; exposed to lead daily by oral gavage at the dose of 80 mg\/Kg b.w.), and group 3 of animals, which were exposed to lead and daily received quercetin (10 h gap time between lead exposure and the receiving of quercetin) by oral gavage at the dose of 350 mg\/Kg b.w. The experiment period was 8 weeks. All the assayed hematological and biochemical parameters of animals exposed to lead were significantly altered compared with the untreated control levels. Animals exposed to lead (group 2) exhibited significant decrements of the erythrocytic and total leucocytic counts, hemoglobin concentration, packed cell volume percent, total proteins, albumin and globulin. These animals also disclosed significantly decreased levels of antioxidant markers including total thiols, catalase and glutathione. On the other hand, these animals demonstrated significant increments in the levels of bilirubin, urea, creatinine, BUN, serum enzymes, H2O2 and MDA. Animals exposed to lead and given quercetin (group 3) exhibited improvement of these parameters, which were brought back at varying degrees toward the untreated control levels. Basing on the improvements of the assayed hematological and biochemical parameters, it was concluded that quercetin as a dietary supplement can act efficiently as an antioxidant to counteract the oxidative stress induced by lead toxicity and to maintain the oxidant antioxidant balance.<\/jats:p>","DOI":"10.3390\/nu15081888","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T01:32:03Z","timestamp":1681435923000},"page":"1888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Quercetin as a Dietary Supplementary Flavonoid Alleviates the Oxidative Stress Induced by Lead Toxicity in Male Wistar Rats"],"prefix":"10.3390","volume":"15","author":[{"given":"Mohammed","family":"Al-Zharani","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Mubarak","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Ahmed","family":"Rudayni","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin A.","family":"Al-Doaiss","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, King Khalid University, Abha 62529, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Abd-Elwahab","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Al-Eissa","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4014\/jmb.1907.07003","article-title":"A review on structure, modifications and structure-activity relation of quercetin and its derivatives","volume":"30","author":"Magar","year":"2020","journal-title":"J. Microbiol. Biotech."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1080\/10408398.2019.1683810","article-title":"A minireview of quercetin: From its metabolism to possible mechanisms of its biological activities","volume":"60","author":"Ulusoy","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficiency of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/jn\/138.5.885","article-title":"Quercetin from shallots (Allium cepa L. var aggregatum) is more bioavailable its glucosoides","volume":"138","author":"Wiczkowski","year":"2008","journal-title":"J. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-7847.194044","article-title":"Overviews of biological importance of quercetin: A bioactive flavonoid","volume":"10","author":"Arulmoli","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abd-Elsalam, H.H., Gamal, M., Naguib, I., Al-Ghobashy, M.A., Zaazaa, H.E., and Abdelkawy, M. (2021). Development of green and efficient extraction methods of quercetin from red onion scales wastes using factorial design for method optimization: A complementary study. Separations, 8.","DOI":"10.3390\/separations8090137"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jnutbio.2014.05.013","article-title":"Quercetin attenuates renal ischemia\/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway","volume":"25","author":"Chen","year":"2014","journal-title":"J. Nutr. Bioch."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Reyes-Farias, M., and Carrasco-Pozo, C. (2019). The anti-cancer effect of quercetin: Molecular implications in cancer metabolism. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133177"},{"key":"ref_9","first-page":"1","article-title":"Quercetin and quercitrin attenuates the inflammatory response and oxidative stress in LPS-induced RAW264.7 cells: In vitro assessment and a theoretical model","volume":"2019","author":"Tang","year":"2019","journal-title":"BioMed Res. IntER."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108454","DOI":"10.1016\/j.jnutbio.2020.108454","article-title":"Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities","volume":"84","author":"Yuan","year":"2020","journal-title":"J. Nutr. Bioch."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"146209","DOI":"10.1016\/j.gene.2022.146209","article-title":"Quercetin mediates TSC2-RHEB-mTOR pathway to regulate chondrocytes autophagy in knee osteoarthritis","volume":"820","author":"Lv","year":"2022","journal-title":"Gene"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Neamtu, A.-A., Maghiar, T.-A., Alaya, A., Olah, N.-K., Turcus, V., Pelea, D., Totolici, B.D., Neamtu, C., Maghiar, A.M., and Mathe, E. (2022). A comprehensive view on the quercetin impact on colorectal cancer. Molecules, 27.","DOI":"10.3390\/molecules27061873"},{"key":"ref_13","first-page":"795","article-title":"A case of mistaken identity, a case of lead toxicity","volume":"20","author":"Smitherman","year":"1991","journal-title":"Am. J. Vet. Med."},{"key":"ref_14","unstructured":"Gogerin, A., Klasassen, A., and Waalkes, M.P. (1995). Metal Toxicology, Academic Press."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5926381","DOI":"10.1155\/2020\/5926381","article-title":"Therapeutic potential of quercetin as an antiatherosclerotic agent in atherosclerotic cardiovascular disease: A review","volume":"20","author":"Deng","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kim, C.H., Kim, J.E., and Song, Y.J. (2020). Antiviral activities of quercetin and isoquercitrin against human herpesviruses. Molecules, 25.","DOI":"10.3390\/molecules25102379"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107701","DOI":"10.1016\/j.yebeh.2020.107701","article-title":"Angelopoulou. Enlightening the neuroprotective effect of quercetin in epilepsy: From mechanism to therapeutic opportunities","volume":"115","author":"Akyuz","year":"2021","journal-title":"Epilepsy Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"153736","DOI":"10.1016\/j.phymed.2021.153736","article-title":"A review on pharmacological activities and synergistic effect of quercetin with small molecule agents","volume":"92","author":"Zou","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"and Maurya, P.K. (2022). Health benefits of quercetin in age-related diseases. Molecules, 27.","DOI":"10.3390\/molecules27082498"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nguyen, T.L.A., and Bhattacharya, D. (2022). Antimicrobial activity of quercetin: An approach to its mechanistic principle. Molecules, 27.","DOI":"10.3390\/molecules27082494"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gasmi, A., Mujawdiya, P.K., Lysiuk, R., Shanaida, M., Peana, M., Gasmi Benahmed, A., Beley, N., Kovalska, N., and Bj\u00f8rklund, G. (2022). Quercetin in the prevention and treatment of coronavirus infections. A focus on SARS-Co-2. Pharmaceuticals, 15.","DOI":"10.3390\/ph15091049"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Remigante, A., Spinelli, S., Straface, E., Gambardella, L., Caruso, D., Falliti, G., Dossena, S., Marino, A., and Morabito, R. (2022). Antioxidant activity of quercetin in a H2O2-induced oxidative stress model in red blood cells: Functional role of Band 3 protein. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231910991"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3389\/fphys.2019.00976","article-title":"The effect of antioxidant on the properties of red blood cells from patients with sickle cell anemia","volume":"10","author":"Hannemann","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0955-2863(01)00219-4","article-title":"Protective effect of quercetin against cigarette tar extract-induced impairment of erythrocyte deformability","volume":"13","author":"Begum","year":"2002","journal-title":"Nutr. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1179\/135100008X308948","article-title":"Effect of quercetin on nicotine-induced biochemical changes and DNA damage in rat peripheral blood lymphocytes","volume":"13","author":"Muthukumaran","year":"2008","journal-title":"Redox Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/B978-0-12-386986-9.00005-3","article-title":"Quercetin in hypoxia-induced oxidative stress: Novel target for neuroprotection","volume":"102","author":"Pandey","year":"2012","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"45489","DOI":"10.18632\/oncotarget.9993","article-title":"Quercetin induces cell apoptosis of myeloma and displays a synergistic effect with dexamethasone in vitro and in vivo xenograft models","volume":"7","author":"He","year":"2016","journal-title":"Oncotarget"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhang, J., Yin, J., Zhao, D., Wang, C., Zhang, Y., and Wang, Y. (2020). Therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis. J. Int. Med. Res., 48.","DOI":"10.1177\/0300060519873461"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/labinvest.2013.156","article-title":"Modulation of PI3k-LxRx-dependent lipogenesis mediated by oxidative\/nitrosative stress contributes to inhibition of HCV replication by quercetin","volume":"94","author":"Jorquera","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wu, W., Li, R., Li, X., He, J., Jiang, S., Liu, S., and Yang, J. (2016). Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses, 8.","DOI":"10.3390\/v8010006"},{"key":"ref_31","first-page":"1934578X2097629","article-title":"Quercetin: Antiviral significance and possible COVID-19 integrative considerations","volume":"15","author":"Agrawal","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3389\/fimmu.2020.01451","article-title":"Quercetin and vitamin C: An experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19)","volume":"11","author":"Biancatelli","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_33","first-page":"1934578X2110427","article-title":"Quercetin supplementation and COVID-19","volume":"16","author":"Boretti","year":"2021","journal-title":"Nat. Prod. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/ptr.6887","article-title":"A role for quercetin in coronavirus disease 2019 (COVID-19)","volume":"35","author":"Derosa","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhang, J., Pavek, P., Kamaraj, R., Ren, L., and Zhang, T. (2021). Dietary phytochemicals as modulators of human pregnane X receptor. Crit. Rev. Food Sci. Nutr., 1\u201323.","DOI":"10.1080\/10408398.2021.1995322"},{"key":"ref_36","first-page":"S98","article-title":"Integrating Childhood and Adult Blood Lead Surveillance to Improve Identification and Intervention Efforts","volume":"25","author":"Egan","year":"2019","journal-title":"J. Public Health Manag. Pract. JPHMP"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/PHH.0000000000000891","article-title":"Childhood Lead Poisoning: A Perpetual Environmental Justice Issue?","volume":"25","author":"Whitehead","year":"2019","journal-title":"J. Public Health Manag. Sapractice JPHMP"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"115681","DOI":"10.1016\/j.taap.2021.115681","article-title":"A systematic review of clinical and laboratory findings of lead poisoning: Lessons from case reports","volume":"429","author":"Samarghandian","year":"2021","journal-title":"Toxicol. App. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15585\/mmwr.mm6355a5","article-title":"Elevated Blood Lead Levels Among Employed Adults\u2014United States, 1994\u20132013","volume":"63","author":"Alarcon","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6603a1","article-title":"Childhood Blood Lead Levels in Children Aged <5 Years\u2014United States, 2009\u20132014","volume":"66","author":"Raymond","year":"2017","journal-title":"MMWR Surveill. Summ"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12011-012-9413-x","article-title":"Association of blood lead with calcium, iron, zinc and hemoglobin in children aged 0-7 years: A large population-based study","volume":"149","author":"Wang","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1111\/jog.12469","article-title":"Lead and trace element levels in placenta, maternal and cord blood: A cross-sectional pilot study","volume":"40","author":"Reddy","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_43","first-page":"27","article-title":"Evaluation and management of lead exposure","volume":"15","author":"Kim","year":"2015","journal-title":"Ann. Occup. Environ. Medicine."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/tqem.20197","article-title":"The proposed lead NAAQS: Is consideration of cost in the clean air act future","volume":"18","author":"Bergeson","year":"2008","journal-title":"Environ. Qual. Mang."},{"key":"ref_45","unstructured":"Rubin, R., and Strayer, D.S. (1986). Environmental and Nutritional Pathology. Rubin Pathology, Clinicopathologic Foundations of Medicine, Lippincot Williams & Wilkins. [5th ed.]."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/10408363.2017.1408562","article-title":"Clinical and molecular aspects of lead toxicity: An update","volume":"54","author":"Mitra","year":"2017","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_47","first-page":"15","article-title":"The effect of lead exposure on pathological changes in the liver and kidney in relation to age in rats","volume":"40","author":"Piasek","year":"1989","journal-title":"Arch. Hg. Rada. Toksikol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0300-483X(91)90186-5","article-title":"The effect of age of exposure on lead-induced testicular toxicity","volume":"69","author":"Sokol","year":"1991","journal-title":"Toxicology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0147-6513(92)90019-Y","article-title":"Accumulation of lead and effects on total lipid derivatives in fresh water fish","volume":"23","author":"Tulas","year":"1992","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_50","first-page":"249","article-title":"Blockade of mammalian and invertebrate calcium channels by lead","volume":"14","author":"Busselberg","year":"1993","journal-title":"Neurotoxicology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02783979","article-title":"Alterations in the hepatic enzymes following experimental lead poisoning","volume":"38","author":"Nehru","year":"1993","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_52","unstructured":"Sherlock, S., and Dodey, J. (1993). Diseases of the Liver and Biliary System, Blackwell Scientific Publication."},{"key":"ref_53","unstructured":"Benjamin, M.M. (1974). Outline of Veterinary Clinical Pathology, The Iowa State University Press. [3rd ed.]."},{"key":"ref_54","unstructured":"Coles, E.H. (1986). Veterinary Clinical Pathology, W.B. Saunders Co.. [3rd ed.]."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5530\/fra.2014.1.1","article-title":"Antioxidant and drug metabolism","volume":"4","author":"Parasuraman","year":"2014","journal-title":"Free. Radic. Antioxid."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0300-483X(03)00151-3","article-title":"Oxidative stress, exercise, and antioxidant supplementation","volume":"189","author":"Urso","year":"2003","journal-title":"Toxicology"},{"key":"ref_57","first-page":"26087","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.redox.2017.10.017","article-title":"Redox-sensitive GFP fusions for monitoring the catalytic mechanism and inactivation of peroxiredoxins in living cells","volume":"14","author":"Staudacher","year":"2018","journal-title":"Redox Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Salvamani, S., Gunasekaran, B., Shaharuddn, N.A., Ahmed, S.A., and Shukar, M.Y. (2014). Antiatherosclerotic effects of plant flavonoids. Biomed. Res. Int., 480258.","DOI":"10.1155\/2014\/480258"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1021\/jf2000647","article-title":"Isolation and characterization of antioxidant protein functions from melinjo (Gnetum gnemon) seeds","volume":"59","author":"Augus","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1017\/S0043933914000610","article-title":"The avian embryo and its antioxidant defense system","volume":"70","author":"Yigit","year":"2014","journal-title":"World Poult. Sci."},{"key":"ref_62","first-page":"106","article-title":"Methods for total antioxidant activity determination: A review","volume":"1","author":"Pisoschi","year":"2011","journal-title":"Bioch. Analyt. Bioch."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Case, A.J. (2017). On the origin of superoxide dismutase: An evolutionary perspective of superoxide-mediated redox signaling. Antioxidants, 6.","DOI":"10.3390\/antiox6040082"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.59566\/IJBS.2008.4089","article-title":"Free radicals and antioxidants in disease and health","volume":"4","author":"He","year":"2008","journal-title":"Int. J. Biomed. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1038\/s41598-017-08115-6","article-title":"AOD: The antioxidant protein database","volume":"7","author":"Feng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_66","first-page":"3731","article-title":"Hematological evaluation of Wister rats exposed to chronic doses of cadmium, mercury and combined cadmium and mercury","volume":"12","author":"Hounkpatin","year":"2003","journal-title":"Afr. J. Biotechnol."},{"key":"ref_67","first-page":"2224","article-title":"Antioxidant activity of Rubia cordfolia against lead toxicity","volume":"3","author":"Lodia","year":"2012","journal-title":"Int. J. Phamacol. Sci. Res."},{"key":"ref_68","first-page":"31","article-title":"Inflammatory response, reactive oxygen species, programmed (necrotic-like and apoptotic) cell death and cancer","volume":"49","author":"Johar","year":"2004","journal-title":"Rocz. Akad. Med. Bialymst."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cbi.2004.09.012","article-title":"Protective role of zinc in nickel induced hepatotoxicity in rats","volume":"150","author":"Dhu","year":"2004","journal-title":"Chem. Biol. Interaction."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.toxrep.2022.02.009","article-title":"Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study","volume":"9","author":"Firoozichahak","year":"2022","journal-title":"Toxicol. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/ajcn\/72.2.653S","article-title":"Thiol homeostasis and supplements in physical exercise","volume":"72","author":"Sen","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_72","first-page":"201","article-title":"Thiol groups of biological importance","volume":"Volume 11","author":"Baron","year":"2006","journal-title":"Advances in Enzymology and Related Areas of Molecular Biology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00170464","article-title":"Molecular evolutionary analysis based on the amino acid sequence of catalase","volume":"37","author":"Hausner","year":"1993","journal-title":"J. Mol. Evol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/10715769509147544","article-title":"Reactions of bovine liver catalase with superoxide with superoxide radicals and hydrogen peroxide","volume":"22","author":"Lardinosis","year":"1995","journal-title":"Free Radic. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"38933","DOI":"10.1074\/jbc.M110.132860","article-title":"Inhibitors of catalase-amyloid interactions protect cells from \u03b2-amyloid induced oxidative stress and toxicity","volume":"285","author":"Habib","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0163-7258(91)90029-L","article-title":"Glutathione metabolism and its role in hepatoxicity","volume":"52","author":"Deleve","year":"1991","journal-title":"Pharmacol. Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: Overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11751","DOI":"10.1021\/ja9018572","article-title":"The molecular mechanism of the catalase reaction","volume":"131","author":"Biarnes","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_79","first-page":"572","article-title":"Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues","volume":"278","author":"Inserria","year":"2000","journal-title":"Am. J. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0891-5849(93)90029-T","article-title":"Oxygen free radicals and metallothionein","volume":"14","author":"Sato","year":"1993","journal-title":"Free Radic. Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2265.2008.03348.x","article-title":"Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism","volume":"70","author":"Torun","year":"2009","journal-title":"Clin. Endocrinol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.3390\/ijms21239149","article-title":"Use of H2O2 to cause oxidative stress, the catalase issue","volume":"21","author":"Coline","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0891-5849(94)90202-X","article-title":"The correlation between active oxygen scavenging and antioxidative effects of flavonoids","volume":"16","author":"Hanasaki","year":"1994","journal-title":"Free Radic. Bio. Med."},{"key":"ref_84","first-page":"1","article-title":"Quercetin: Its main pharmacological activity and potential application in clinical medicine","volume":"20","author":"Yang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Xu, D., Hu, M.J., Wang, Y.Q., and Cui, Y.L. (2019). Antioxidant activities of quercetin and its complexes for medicinal application. Molecules, 24.","DOI":"10.3390\/molecules24061123"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Tsai, C.F., Chen, G.W., Chen, Y.C., Shen, C.K., Lu, D.Y., Yang, L.Y., Chen, J.H., and Yeh, W.L. (2021). Regulatory effects of quercetin on M1\/M2 macrophage polarization and oxidative\/antioxidative balance. Nutrients, 14.","DOI":"10.3390\/nu14010067"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3892\/or.2016.5217","article-title":"Protective effects of quercetin on UVB irradiation-induced cytotoxicity through ROS clearance in keratinocyte cells","volume":"37","author":"Zhu","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.fitote.2011.01.018","article-title":"Antioxidant and prooxidant properties of flavonoids","volume":"82","author":"Prochazkova","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1021\/acs.jafc.9b04154","article-title":"Preparation of quercetin esters and their antioxidant activity","volume":"67","author":"Oh","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1021\/acs.jafc.0c07273","article-title":"Antioxidative properties and chemical changes of quercetin in fish oil: Quercetin reacts with free fatty acids to form its ester derivatives","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10517-018-4167-x","article-title":"The effects of dihydroquercetin on catalytic activity of iron (II) ions in the Fenton reaction","volume":"165","author":"Babenkova","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.fct.2014.02.022","article-title":"Quercetin attenuates chronic ethanol hepatotoxicity: Implication of free iron uptake and release","volume":"67","author":"Tang","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"113108","DOI":"10.1016\/j.biopha.2022.113108","article-title":"Quercetin ameliorates oxidative stress induced cell apoptosis of seminal vesicles via activating Nrf2 in type 1 diabetic rats","volume":"151","author":"Dong","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e22241","DOI":"10.1097\/MD.0000000000022241","article-title":"Quercetin inhibits TNF-\u03b1 induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"151819","DOI":"10.1016\/j.acthis.2021.151819","article-title":"Quercetin regulates inflammation, oxidative stress, apoptosis, and mitochondrial structure and function in H9C2 cells by promoting PVT1 expression","volume":"123","author":"Li","year":"2021","journal-title":"Acta Histochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11010-009-0026-4","article-title":"Isoenzyme-specific up-regulation of glutathione transferase and aldo-keto reductase mRNA expression by dietary quercetin in rat liver","volume":"325","author":"Odbayar","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jff.2015.04.006","article-title":"Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice","volume":"15","author":"Kobori","year":"2015","journal-title":"J. Funct. Foods."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/8\/1888\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:15:34Z","timestamp":1760123734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/8\/1888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":97,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["nu15081888"],"URL":"https:\/\/doi.org\/10.3390\/nu15081888","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]}}}