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Specifically, the expression of keratin 16, keratin 17, and involucrin were substantially decreased by administration of 109 CFU and 1010 CFU per day. Moreover, interleukin (IL)-17 and TNF-\u03b1 levels were substantially decreased by 109 and 1010 CFU\/day. Furthermore, the gut microbiota in mice treated with 109 or 1010 CFU\/day was rebalanced by improving the diversity, regulating microbe interactions, increasing Lachnoclostridium, and decreasing Oscillibacter. Moreover, the concentrations of colonic bile acids were positively correlated with the effectiveness of the strain in relieving psoriasis. The gavage dose should be more than 108.42 CFU\/day to improve psoriasis according to the dose\u2013effect curve. In conclusion, CCFM683 supplementation alleviated psoriasis in a dose-dependent manner by recovering microbiota, promoting bile acid production, regulating the FXR\/NF-\u03baB pathway, diminishing proinflammatory cytokines, regulating keratinocytes, and maintaining the epidermal barrier function. These results may help guide probiotic product development and clinical trials in psoriasis.<\/jats:p>","DOI":"10.3390\/nu15081952","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:09:22Z","timestamp":1681866562000},"page":"1952","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dose\u2013Response Efficacy and Mechanisms of Orally Administered Bifidobacterium breve CCFM683 on IMQ-Induced Psoriasis in Mice"],"prefix":"10.3390","volume":"15","author":[{"given":"Xinqi","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214126, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214126, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-7011","authenticated-orcid":false,"given":"Catherine","family":"Stanton","sequence":"additional","affiliation":[{"name":"International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214126, China"},{"name":"APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland"},{"name":"Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-8839","authenticated-orcid":false,"given":"Reynolds Paul","family":"Ross","sequence":"additional","affiliation":[{"name":"International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214126, China"},{"name":"APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214126, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214126, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-3718","authenticated-orcid":false,"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214126, China"},{"name":"International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214126, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. 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