{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:56:16Z","timestamp":1784260576992,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Crohn\u2019s disease (CD) is a chronic inflammatory disorder that may occur in any segment of the gastrointestinal tract. Asymptomatic or untreated inflammation along with malnutrition can often coexist in patients with CD, impairing clinical outcomes, therefore the aim of this study was to assess the relationship between inflammation, malnutrition risk and nutritional status in CD patients. Consecutive adult CD outpatients aged 18-65 years were recruited. Disease activity was clinically defined by the Crohn\u2019s Disease Activity Index (CDAI), whilst anthropometry and phase angle (PhA) were measured. The Controlling Nutritional Status (CONUT) score was retrospectively calculated for screening malnutrition risk and blood samples were taken. A total of 140 CD patients with a mean age of 38.8 \u00b1 13.9 years and an average weight of 64.9 \u00b1 12.0 kg were included. Serum interleukin (IL)-6 concentration was increased in active-CD patients, unrelated to medical treatment, which was associated with CDAI and PhA. Based on the CONUT score, the prevalence of patients with moderate\/severe malnutrition risk (score \u2265 5) was 10%, showing lower age, body mass index and fat mass, but higher IL-6 and IL-1\u03b2 levels than subjects classified as not at risk (score 0\u20131). Finally, increased IL-6 levels and reduced PhA values were identified as independent predictors of moderate\/severe malnutrition risk (p &lt; 0.05). In conclusion, IL-6 increased in active-CD patients, which was inversely correlated with PhA. Although the CONUT score might be helpful for identifying CD patients at moderate\/severe risk of malnutrition, larger studies are needed to verify these results in different settings.<\/jats:p>","DOI":"10.3390\/nu15081953","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:09:22Z","timestamp":1681866562000},"page":"1953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-209X","authenticated-orcid":false,"given":"Iolanda","family":"Cioffi","sequence":"first","affiliation":[{"name":"Department of Food, Environmental and Nutritional Sciences\u2014DEFENS, Division of Human Nutrition, Universit\u00e0 degli Studi di Milano, Celoria 2, 20133 Milan, Italy"},{"name":"Department of Clinical Medicine and Surgery, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-7315","authenticated-orcid":false,"given":"Filippo","family":"Scial\u00f2","sequence":"additional","affiliation":[{"name":"CEINGE\u2014Biotecnologie Avanzate F. Salvatore, s.c.ar.l, 80145 Napoli, Italy"},{"name":"Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-3130","authenticated-orcid":false,"given":"Olivia","family":"Di Vincenzo","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1500-0746","authenticated-orcid":false,"given":"Monica","family":"Gelzo","sequence":"additional","affiliation":[{"name":"CEINGE\u2014Biotecnologie Avanzate F. Salvatore, s.c.ar.l, 80145 Napoli, Italy"},{"name":"Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3258-7374","authenticated-orcid":false,"given":"Maurizio","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4328-5267","authenticated-orcid":false,"given":"Anna","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-3132","authenticated-orcid":false,"given":"Maria","family":"Vitale","sequence":"additional","affiliation":[{"name":"CEINGE\u2014Biotecnologie Avanzate F. Salvatore, s.c.ar.l, 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-7821","authenticated-orcid":false,"given":"Fabrizio","family":"Pasanisi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-4836","authenticated-orcid":false,"given":"Lidia","family":"Santarpia","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University Hospital, Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/apt.15190","article-title":"One-Year Clinical Outcomes with Biologics in Crohn\u2019s Disease: Transmural Healing Compared with Mucosal or No Healing","volume":"49","author":"Castiglione","year":"2019","journal-title":"Aliment. 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