{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:00:58Z","timestamp":1787068858914,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LaMarat\u00f3-TV3","award":["DIM-2-ELI"],"award-info":[{"award-number":["DIM-2-ELI"]}]},{"name":"LaMarat\u00f3-TV3","award":["FBG308556"],"award-info":[{"award-number":["FBG308556"]}]},{"name":"LaMarat\u00f3-TV3","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"DOI":"10.13039\/100007772","name":"Nutricia Research","doi-asserted-by":"publisher","award":["DIM-2-ELI"],"award-info":[{"award-number":["DIM-2-ELI"]}],"id":[{"id":"10.13039\/100007772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007772","name":"Nutricia Research","doi-asserted-by":"publisher","award":["FBG308556"],"award-info":[{"award-number":["FBG308556"]}],"id":[{"id":"10.13039\/100007772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007772","name":"Nutricia Research","doi-asserted-by":"publisher","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}],"id":[{"id":"10.13039\/100007772","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maria de Maeztu Unit of Excellence grant funded by MICIN\/AEI\/FEDER, UE","award":["DIM-2-ELI"],"award-info":[{"award-number":["DIM-2-ELI"]}]},{"name":"Maria de Maeztu Unit of Excellence grant funded by MICIN\/AEI\/FEDER, UE","award":["FBG308556"],"award-info":[{"award-number":["FBG308556"]}]},{"name":"Maria de Maeztu Unit of Excellence grant funded by MICIN\/AEI\/FEDER, UE","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Viral infections are described as modifying host gene expression; however, there is limited insight regarding rotavirus (RV) infections. This study aimed to assess the changes in intestinal gene expression after RV infection in a preclinical model, and the effect of 2-fucosyllactose (2\u2032-FL) on this process. From days 2 to 8 of life, rats were supplemented with the dietary oligosaccharide 2\u2032-FL or vehicle. In addition, an RV was inoculated on day 5 to nonsupplemented animals (RV group) and to 2\u2032-FL-fed animals (RV+2\u2032-FL group). Incidence and severity of diarrhea were established. A portion from the middle part of the small intestine was excised for gene expression analysis by microarray kit and qPCR. In nonsupplemented animals, RV-induced diarrhea upregulated host antiviral genes (e.g., Oas1a, Irf7, Ifi44, Isg15) and downregulated several genes involved in absorptive processes and intestinal maturation (e.g., Onecut2, and Ccl19). The 2\u2032-FL-supplemented and infected animals had less diarrhea; however, their gene expression was affected in a similar way as the control-infected animals, with the exception of some immunity\/maturation markers that were differentially expressed (e.g., Ccl12 and Afp). Overall, assessing the expression of these key genes may be useful in the evaluation of the efficacy of nutritional interventions or treatments for RV infection.<\/jats:p>","DOI":"10.3390\/nu15081996","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T01:33:43Z","timestamp":1682040823000},"page":"1996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Rotavirus Infection and 2\u2032-Fucosyllactose Administration on Rat Intestinal Gene Expression"],"prefix":"10.3390","volume":"15","author":[{"given":"Laura","family":"S\u00e1ez-Fuertes","sequence":"first","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Azagra-Boronat","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-2793","authenticated-orcid":false,"given":"Mal\u00e9n","family":"Massot-Cladera","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3700-9047","authenticated-orcid":false,"given":"Karen","family":"Knipping","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research, 3584 CT Utrecht, The Netherlands"},{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CA Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-9182","authenticated-orcid":false,"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research, 3584 CT Utrecht, The Netherlands"},{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CA Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-1374","authenticated-orcid":false,"given":"\u00c0ngels","family":"Franch","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-0593","authenticated-orcid":false,"given":"Margarida","family":"Castell","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-9164","authenticated-orcid":false,"given":"Francisco J.","family":"P\u00e9rez-Cano","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-8250","authenticated-orcid":false,"given":"Mar\u00eda J.","family":"Rodr\u00edguez-Lagunas","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, April 05). 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