{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:02:25Z","timestamp":1792072945334,"version":"4.4.0"},"reference-count":288,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause\u2013effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field.<\/jats:p>","DOI":"10.3390\/nu15102335","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:58:06Z","timestamp":1684288686000},"page":"2335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution"],"prefix":"10.3390","volume":"15","author":[{"given":"Arianna","family":"Dolce","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-5266","authenticated-orcid":false,"given":"Sara","family":"Della Torre","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The Global Epidemiology of Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH): A Systematic Review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatol. Baltim. Md"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41575-021-00448-y","article-title":"The Complex Link between NAFLD and Type 2 Diabetes Mellitus\u2014Mechanisms and Treatments","volume":"18","author":"Targher","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"154170","DOI":"10.1016\/j.metabol.2020.154170","article-title":"Complications, Morbidity and Mortality of Nonalcoholic Fatty Liver Disease","volume":"111","author":"Mantovani","year":"2020","journal-title":"Metabolism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-Alcoholic Fatty Liver Disease and Its Relationship with Cardiovascular Disease and Other Extrahepatic Diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-Alcoholic Fatty Liver Disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9547613","DOI":"10.1155\/2018\/9547613","article-title":"Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease","volume":"2018","author":"Masarone","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Monserrat-Mesquida, M., Quetglas-Llabr\u00e9s, M., Abbate, M., Montemayor, S., Mascar\u00f3, C.M., Casares, M., Tejada, S., Abete, I., Zulet, M.A., and Tur, J.A. (2020). Oxidative Stress and Pro-Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9080759"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic Reticulum Stress Signalling and the Pathogenesis of Non-Alcoholic Fatty Liver Disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and Resolution of Inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The Role of Macrophages in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"597648","DOI":"10.3389\/fendo.2020.597648","article-title":"Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies","volume":"11","author":"Luci","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The Prevalence and Incidence of NAFLD Worldwide: A Systematic Review and Meta-Analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/hep.31807","article-title":"Ten Thousand Points of Light: Heterogeneity Among the Stars of NASH Fibrosis","volume":"74","author":"Carter","year":"2021","journal-title":"Hepatology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101111","DOI":"10.1016\/j.molmet.2020.101111","article-title":"Genetic and Epigenetic Factors Determining NAFLD Risk","volume":"50","author":"Jonas","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21037\/tgh.2019.09.06","article-title":"Genetic and Epigenetic Disease Modifiers: Non-Alcoholic Fatty Liver Disease (NAFLD) and Alcoholic Liver Disease (ALD)","volume":"6","author":"Choudhary","year":"2021","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_16","first-page":"102","article-title":"The Role of Nutrition in Non-Alcoholic Fatty Liver Disease: Pathophysiology and Management","volume":"40","year":"2020","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41575-021-00472-y","article-title":"Dietary Carbohydrates and Fats in Nonalcoholic Fatty Liver Disease","volume":"18","author":"Luukkonen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jhepr.2019.10.008","article-title":"Lifestyle Modification in NAFLD\/NASH: Facts and Figures","volume":"1","author":"Hallsworth","year":"2019","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41575-020-0269-9","article-title":"Gut Microbiota and Human NAFLD: Disentangling Microbial Signatures from Metabolic Disorders","volume":"17","author":"Vigliotti","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e9302","DOI":"10.15252\/emmm.201809302","article-title":"The Role of the Microbiome in NAFLD and NASH","volume":"11","author":"Kolodziejczyk","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI134165","article-title":"Insulin Resistance Drives Hepatic de Novo Lipogenesis in Nonalcoholic Fatty Liver Disease","volume":"130","author":"Smith","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2018.01.019","article-title":"Fructose and Sugar: A Major Mediator of Non-Alcoholic Fatty Liver Disease","volume":"68","author":"Jensen","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Della Torre, S. (2021). Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology. Cells, 10.","DOI":"10.3390\/cells10092502"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"572490","DOI":"10.3389\/fendo.2020.572490","article-title":"Non-Alcoholic Fatty Liver Disease as a Canonical Example of Metabolic Inflammatory-Based Liver Disease Showing a Sex-Specific Prevalence: Relevance of Estrogen Signaling","volume":"11","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11806","DOI":"10.1073\/pnas.1205797109","article-title":"Tetradian Oscillation of Estrogen Receptor Is Necessary to Prevent Liver Lipid Deposition","volume":"109","author":"Villa","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.celrep.2016.03.019","article-title":"An Essential Role for Liver ER\u03b1 in Coupling Hepatic Metabolism to the Reproductive Cycle","volume":"15","author":"Mitro","year":"2016","journal-title":"Cell Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1038\/s41467-021-27272-x","article-title":"Dietary Essential Amino Acids Restore Liver Metabolism in Ovariectomized Mice via Hepatic Estrogen Receptor \u03b1","volume":"12","author":"Benedusi","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cmet.2018.05.021","article-title":"Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver","volume":"28","author":"Mitro","year":"2018","journal-title":"Cell Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molmet.2019.12.009","article-title":"Hepatic ER\u03b1 Accounts for Sex Differences in the Ability to Cope with an Excess of Dietary Lipids","volume":"32","author":"Meda","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/hep.29465","article-title":"Altered Amino Acid Concentrations in NAFLD: Impact of Obesity and Insulin Resistance","volume":"67","author":"Gaggini","year":"2018","journal-title":"Hepatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00726-014-1894-9","article-title":"Branched Chain Amino Acid Metabolism Profiles in Progressive Human Nonalcoholic Fatty Liver Disease","volume":"47","author":"Lake","year":"2015","journal-title":"Amino Acids"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"dgaa175","DOI":"10.1210\/clinem\/dgaa175","article-title":"Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent","volume":"105","author":"Grzych","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.metabol.2016.12.013","article-title":"Branched-Chain Amino Acids Alleviate Hepatic Steatosis and Liver Injury in Choline-Deficient High-Fat Diet Induced NASH Mice","volume":"69","author":"Honda","year":"2017","journal-title":"Metabolism"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cmet.2017.01.006","article-title":"Sex Differences: A Resultant of an Evolutionary Pressure?","volume":"25","author":"Maggi","year":"2017","journal-title":"Cell Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molmet.2018.02.012","article-title":"Sex, Metabolism and Health","volume":"15","author":"Maggi","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.prp.2013.04.010","article-title":"Presence and Extent of Estrogen Receptor-Alpha Expression in Patients with Simple Steatosis and NASH","volume":"209","author":"Erkan","year":"2013","journal-title":"Pathol. Res. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00125-021-05618-w","article-title":"Environmental Risk Factors of Type 2 Diabetes\u2014An Exposome Approach","volume":"65","author":"Beulens","year":"2022","journal-title":"Diabetologia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"154337","DOI":"10.1016\/j.metabol.2020.154337","article-title":"Perturbation of the Circadian Clock and Pathogenesis of NAFLD","volume":"111S","author":"Mukherji","year":"2020","journal-title":"Metabolism"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Guo, W., Pan, B., Sakkiah, S., Yavas, G., Ge, W., Zou, W., Tong, W., and Hong, H. (2019). Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods. Int. J. Environ. Res. Public. Health, 16.","DOI":"10.3390\/ijerph16224361"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jnutbio.2015.09.019","article-title":"Macronutrient Composition Determines Accumulation of Persistent Organic Pollutants from Dietary Exposure in Adipose Tissue of Mice","volume":"27","author":"Myrmel","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"115350","DOI":"10.1016\/j.envres.2023.115350","article-title":"Cross-Sectional Associations of Persistent Organic Pollutants Measured in Adipose Tissue and Metabolic Syndrome in Clinically Diagnosed Middle-Aged Adults","volume":"222","author":"Mustieles","year":"2023","journal-title":"Environ. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"142458","DOI":"10.1016\/j.scitotenv.2020.142458","article-title":"Accumulation of Distinct Persistent Organic Pollutants Is Associated with Adipose Tissue Inflammation","volume":"748","author":"Gebauer","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Moriceau, M.-A., Cano-Sancho, G., Kim, M., Coumoul, X., Emond, C., Arrebola, J.-P., Antignac, J.-P., Audouze, K., and Rousselle, C. (2022). Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies. Toxics, 11.","DOI":"10.3390\/toxics11010041"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.envres.2014.07.023","article-title":"Persistent Organic Pollutants and Liver Dysfunction Biomarkers in a Population-Based Human Sample of Men and Women","volume":"134","author":"Kumar","year":"2014","journal-title":"Environ. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40572-017-0166-8","article-title":"Persistent Endocrine-Disrupting Chemicals and Fatty Liver Disease","volume":"4","author":"Deierlein","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cano, R., P\u00e9rez, J.L., D\u00e1vila, L.A., Ortega, \u00c1., G\u00f3mez, Y., Valero-Cede\u00f1o, N.J., Parra, H., Manzano, A., V\u00e9liz Castro, T.I., and Albornoz, M.P.D. (2021). Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094807"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41574-019-0273-8","article-title":"Consensus on the Key Characteristics of Endocrine-Disrupting Chemicals as a Basis for Hazard Identification","volume":"16","author":"Vandenberg","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-012110-142200","article-title":"Endocrine Disruptors: From Endocrine to Metabolic Disruption","volume":"73","author":"Desvergne","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrendo.2017.42","article-title":"Endocrine-Disrupting Chemicals and Fatty Liver Disease","volume":"13","author":"Foulds","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1530\/JOE-17-0028","article-title":"Bisphenol A Promotes Hepatic Lipid Deposition Involving Kupffer Cells M1 Polarization in Male Mice","volume":"234","author":"Lv","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1047827","DOI":"10.3389\/fnut.2022.1047827","article-title":"An Insight into Bisphenol A, Food Exposure and Its Adverse Effects on Health: A Review","volume":"9","author":"Manzoor","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/jama.300.11.1353","article-title":"Bisphenol A and Risk of Metabolic Disorders","volume":"300","author":"Myers","year":"2008","journal-title":"JAMA"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Dallio, M., Diano, N., Masarone, M., Gravina, A.G., Patan\u00e8, V., Romeo, M., Di Sarno, R., Errico, S., Nicolucci, C., and Abenavoli, L. (2019). Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease. Int. J. Environ. Res. Public. Health, 16.","DOI":"10.3390\/ijerph16173134"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12199-021-01010-7","article-title":"The Association between Urinary Bisphenol A Levels and Nonalcoholic Fatty Liver Disease in Korean Adults: Korean National Environmental Health Survey (KoNEHS) 2015\u20132017","volume":"26","author":"An","year":"2021","journal-title":"Environ. Health Prev. Med."},{"key":"ref_55","first-page":"1335","article-title":"Elevated Urinary Bisphenol A Levels Are Associated with Non-Alcoholic Fatty Liver Disease among Adults in the United States","volume":"39","author":"Kim","year":"2019","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3892\/etm.2022.11671","article-title":"Bisphenol A Is a Carcinogen That Induces Lipid Accumulation, Peroxisome Proliferator-activated Receptor-\u03b3 Expression and Liver Disease","volume":"24","author":"Ismael","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109492","DOI":"10.1016\/j.ecoenv.2019.109492","article-title":"Bisphenol A Inhibits Autophagosome-Lysosome Fusion and Lipid Droplet Degradation","volume":"183","author":"Song","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.chemosphere.2013.01.016","article-title":"Direct Effects of Bisphenol A on Lipid Homeostasis in Rat Hepatoma Cells","volume":"91","author":"Grasselli","year":"2013","journal-title":"Chemosphere"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/apt.14499","article-title":"Role of Bisphenol A as Environmental Factor in the Promotion of Non-Alcoholic Fatty Liver Disease: In Vitro and Clinical Study","volume":"47","author":"Dallio","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Federico, A., Dallio, M., Gravina, A.G., Diano, N., Errico, S., Masarone, M., Romeo, M., Tuccillo, C., Stiuso, P., and Morisco, F. (2020). The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease. Int. J. Environ. Res. Public. Health, 17.","DOI":"10.3390\/ijerph17103369"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/iep.12207","article-title":"Inflammation, Oxidative Stress and Apoptosis Cascade Implications in Bisphenol A-Induced Liver Fibrosis in Male Rats","volume":"97","author":"Elswefy","year":"2016","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lee, J.-L., Wang, Y.-C., Hsu, Y.-A., Chen, C.-S., Weng, R.-C., Lu, Y.-P., Chuang, C.-Y., and Wan, L. (2022). Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression. Toxics, 10.","DOI":"10.3390\/toxics10050208"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"114880","DOI":"10.1016\/j.envpol.2020.114880","article-title":"Bisphenol A Exposure Induces Gut Microbiota Dysbiosis and Consequent Activation of Gut-Liver Axis Leading to Hepatic Steatosis in CD-1 Mice","volume":"265","author":"Feng","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Liu, R., Liu, B., Tian, L., Jiang, X., Li, X., Cai, D., Sun, J., Bai, W., and Jin, Y. (2022). Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23148042"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"118012","DOI":"10.1016\/j.lfs.2020.118012","article-title":"Bisphenol-A Exposure Worsens Hepatic Steatosis in Ovariectomized Mice Fed on a High-Fat Diet: Role of Endoplasmic Reticulum Stress and Fibrogenic Pathways","volume":"256","author":"Figueiredo","year":"2020","journal-title":"Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.envres.2017.06.011","article-title":"Estimating Human Exposure to Perfluoroalkyl Acids via Solid Food and Drinks: Implementation and Comparison of Different Dietary Assessment Methods","volume":"158","author":"Papadopoulou","year":"2017","journal-title":"Environ. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"077004","DOI":"10.1289\/EHP6785","article-title":"Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam","volume":"128","author":"Xu","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"100694","DOI":"10.1016\/j.jhepr.2023.100694","article-title":"Association of Per- and Polyfluoroalkyl Substance Exposure with Fatty Liver Disease Risk in US Adults","volume":"5","author":"Zhang","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"105220","DOI":"10.1016\/j.envint.2019.105220","article-title":"Perfluoroalkyl Substances and Severity of Nonalcoholic Fatty Liver in Children: An Untargeted Metabolomics Approach","volume":"134","author":"Jin","year":"2020","journal-title":"Environ. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"46001","DOI":"10.1289\/EHP10092","article-title":"Exposure to Per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis","volume":"130","author":"Costello","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbagen.2012.03.010","article-title":"PFOS-Induced Hepatic Steatosis, the Mechanistic Actions on \u03b2-Oxidation and Lipid Transport","volume":"1820","author":"Wan","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"115250","DOI":"10.1016\/j.taap.2020.115250","article-title":"Perfluorooctanesulfonic Acid (PFOS) Administration Shifts the Hepatic Proteome and Augments Dietary Outcomes Related to Hepatic Steatosis in Mice","volume":"408","author":"Marques","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/jat.4258","article-title":"PFOS Facilitates Liver Inflammation and Steatosis: An Involvement of NLRP3 Inflammasome-Mediated Hepatocyte Pyroptosis","volume":"42","author":"Qin","year":"2022","journal-title":"J. Appl. Toxicol. JAT"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1007\/s00204-020-02808-0","article-title":"Perfluorooctanoic Acid (PFOA), Perfluorooctane Sulfonic Acid (PFOS), and Perfluorononanoic Acid (PFNA) Increase Triglyceride Levels and Decrease Cholesterogenic Gene Expression in Human HepaRG Liver Cells","volume":"94","author":"Louisse","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2019.01.017","article-title":"The Effects of Perfluorooctanoate on High Fat Diet Induced Non-Alcoholic Fatty Liver Disease in Mice","volume":"416","author":"Li","year":"2019","journal-title":"Toxicology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/toxsci\/kfaa172","article-title":"An \u2019Omics Approach to Unraveling the Paradoxical Effect of Diet on Perfluorooctanesulfonic Acid (PFOS) and Perfluorononanoic Acid (PFNA)-Induced Hepatic Steatosis","volume":"180","author":"Pfohl","year":"2021","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tox.2016.12.007","article-title":"Perfluoroalkyl Acids-Induced Liver Steatosis: Effects on Genes Controlling Lipid Homeostasis","volume":"378","author":"Das","year":"2017","journal-title":"Toxicology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.06.012","article-title":"Multiplicity of Nuclear Receptor Activation by PFOA and PFOS in Primary Human and Rodent Hepatocytes","volume":"288","author":"Bjork","year":"2011","journal-title":"Toxicology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tox.2017.05.013","article-title":"PPAR\u03b1-Independent Transcriptional Targets of Perfluoroalkyl Acids Revealed by Transcript Profiling","volume":"387","author":"Rosen","year":"2017","journal-title":"Toxicology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fct.2016.09.017","article-title":"Gender Differences in Pharmacokinetics and Tissue Distribution of 3 Perfluoroalkyl and Polyfluoroalkyl Substances in Rats","volume":"97","author":"Kim","year":"2016","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.toxrep.2019.06.016","article-title":"Toxicokinetics of Perfluorobutane Sulfonate (PFBS), Perfluorohexane-1-Sulphonic Acid (PFHxS), and Perfluorooctane Sulfonic Acid (PFOS) in Male and Female Hsd:Sprague Dawley SD Rats after Intravenous and Gavage Administration","volume":"6","author":"Huang","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"113061","DOI":"10.1016\/j.envpol.2019.113061","article-title":"Sex Differences in the Association between Perfluoroalkyl Acids and Liver Function in US Adolescents: Analyses of NHANES 2013-2016","volume":"254","author":"Attanasio","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"44292","DOI":"10.1007\/s11356-023-25258-4","article-title":"Association between Perfluoroalkyl Substances Exposure and the Prevalence of Nonalcoholic Fatty Liver Disease in the Different Sexes: A Study from the National Health and Nutrition Examination Survey 2005\u20132018","volume":"30","author":"Limei","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"106843","DOI":"10.1016\/j.envint.2021.106843","article-title":"Exposure to a Mixture of Legacy, Alternative, and Replacement per- and Polyfluoroalkyl Substances (PFAS) Results in Sex-Dependent Modulation of Cholesterol Metabolism and Liver Injury","volume":"157","author":"Roth","year":"2021","journal-title":"Environ. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0192623314549960","article-title":"Identification of Environmental Chemicals Associated with the Development of Toxicant-Associated Fatty Liver Disease in Rodents","volume":"43","author":"Wahlang","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"119915","DOI":"10.1016\/j.envpol.2022.119915","article-title":"Analysis of Environmental Chemical Mixtures and Nonalcoholic Fatty Liver Disease: NHANES 1999\u20132014","volume":"311","author":"Li","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1007\/s10620-021-07203-y","article-title":"Environmental Toxicants and NAFLD: A Neglected yet Significant Relationship","volume":"67","author":"Rajak","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40572-019-00231-x","article-title":"Understanding Environmental Contaminants\u2019 Direct Effects on Non-Alcoholic Fatty Liver Disease Progression","volume":"6","author":"Armstrong","year":"2019","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1038\/s41598-022-15741-2","article-title":"Association between Organochlorine Pesticides and Nonalcoholic Fatty Liver Disease in the National Health and Nutrition Examination Survey 2003\u20132004","volume":"12","author":"Sang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"112155","DOI":"10.1016\/j.fct.2021.112155","article-title":"Investigation of Steatosis Profiles Induced by Pesticides Using Liver Organ-on-Chip Model and Omics Analysis","volume":"152","author":"Jellali","year":"2021","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"100185","DOI":"10.1016\/j.ese.2022.100185","article-title":"Gut Microbiota Dysbiosis Involves in Host Non-Alcoholic Fatty Liver Disease upon Pyrethroid Pesticide Exposure","volume":"11","author":"Li","year":"2022","journal-title":"Environ. Sci. Ecotechnol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1038\/s41467-021-25384-y","article-title":"The Pesticide Chlorpyrifos Promotes Obesity by Inhibiting Diet-Induced Thermogenesis in Brown Adipose Tissue","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41598-020-79479-5","article-title":"The Potential Ameliorative Impacts of Cerium Oxide Nanoparticles against Fipronil-Induced Hepatic Steatosis","volume":"11","author":"Wasef","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"129727","DOI":"10.1016\/j.chemosphere.2021.129727","article-title":"Thiamethoxam Induces Nonalcoholic Fatty Liver Disease in Mice via Methionine Metabolism Disturb via Nicotinamide N-Methyltransferase Overexpression","volume":"273","author":"Yang","year":"2021","journal-title":"Chemosphere"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/toxsci\/kfac129","article-title":"Myclobutanil-Mediated Alteration of Liver-Gut FXR Signaling in Mice","volume":"191","author":"Taylor","year":"2023","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2016.09.013","article-title":"Myclobutanil Worsens Nonalcoholic Fatty Liver Disease: An in Vitro Study of Toxicity and Apoptosis on HepG2 Cells","volume":"262","author":"Stellavato","year":"2016","journal-title":"Toxicol. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2016.03.004","article-title":"Mancozeb, a Fungicide Routinely Used in Agriculture, Worsens Nonalcoholic Fatty Liver Disease in the Human HepG2 Cell Model","volume":"249","author":"Pirozzi","year":"2016","journal-title":"Toxicol. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Stossi, F., Dandekar, R.D., Johnson, H., Lavere, P., Foulds, C.E., Mancini, M.G., and Mancini, M.A. (2019). Tributyltin Chloride (TBT) Induces RXRA down-Regulation and Lipid Accumulation in Human Liver Cells. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224405"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"112585","DOI":"10.1016\/j.fct.2021.112585","article-title":"Polychlorinated Dibenzo-p-Dioxins and Dibenzofurans (PCDD\/Fs) in Food and Human Dietary Intake: An Update of the Scientific Literature","volume":"157","author":"Domingo","year":"2021","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.chemosphere.2015.10.089","article-title":"Estimated Dietary Intake and Risk Assessment of Polychlorinated Dibenzo-p-Dioxins and Dibenzofurans and Dioxin-like Polychlorinated Biphenyls from Fish Consumption in the Korean General Population","volume":"146","author":"Shin","year":"2016","journal-title":"Chemosphere"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.taap.2015.07.018","article-title":"Transcriptional Profiling of Rat White Adipose Tissue Response to 2,3,7,8-Tetrachlorodibenzo-\u03c1-Dioxin","volume":"288","author":"Houlahan","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.reprotox.2020.06.004","article-title":"Serum Dioxin Levels and Sperm DNA Methylation Age: Findings in Vietnam War Veterans Exposed to Agent Orange","volume":"96","author":"Jenkins","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfs277","article-title":"TCDD-Elicited Effects on Liver, Serum, and Adipose Lipid Composition in C57BL\/6 Mice","volume":"131","author":"Angrish","year":"2013","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2004.12.003","article-title":"2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Alters the MRNA Expression of Critical Genes Associated with Cholesterol Metabolism, Bile Acid Biosynthesis, and Bile Transport in Rat Liver: A Microarray Study","volume":"207","author":"Fletcher","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1038\/s41598-017-05656-8","article-title":"2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Elicited Effects on Bile Acid Homeostasis: Alterations in Biosynthesis, Enterohepatic Circulation, and Microbial Metabolism","volume":"7","author":"Fader","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Fling, R.R., and Zacharewski, T.R. (2021). Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 22.","DOI":"10.1101\/2021.11.02.466980"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"14831","DOI":"10.1038\/s41598-020-71795-0","article-title":"2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dysregulates Hepatic One Carbon Metabolism during the Progression of Steatosis to Steatohepatitis with Fibrosis in Mice","volume":"10","author":"Fling","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cotox.2019.06.001","article-title":"Polychlorinated Biphenyls and Nonalcoholic Fatty Liver Disease","volume":"14","author":"Wahlang","year":"2019","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1289\/EHP316","article-title":"Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL\/6J Diet-Induced Obesity Mouse Model","volume":"125","author":"Duval","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_110","first-page":"1247","article-title":"Dioxin-like and Non-Dioxin-like PCBs Differentially Regulate the Hepatic Proteome and Modify Diet-Induced Nonalcoholic Fatty Liver Disease Severity","volume":"29","author":"Jin","year":"2020","journal-title":"Med. Chem. Res. Int. J. Rapid Commun. Des. Mech. Action Biol. Act. Agents"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jnutbio.2013.01.009","article-title":"Polychlorinated Biphenyl 153 Is a Diet-Dependent Obesogen That Worsens Nonalcoholic Fatty Liver Disease in Male C57BL6\/J Mice","volume":"24","author":"Wahlang","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Lee, J., Prokopec, S.D., Watson, J.D., Sun, R.X., Pohjanvirta, R., and Boutros, P.C. (2015). Male and Female Mice Show Significant Differences in Hepatic Transcriptomic Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. BMC Genomics, 16.","DOI":"10.1186\/s12864-015-1840-6"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Nault, R., Fader, K.A., Harkema, J.R., and Zacharewski, T. (2017). Loss of Liver-Specific and Sexually Dimorphic Gene Expression by Aryl Hydrocarbon Receptor Activation in C57BL\/6 Mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184842"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.taap.2015.02.012","article-title":"Sex-Related Differences in Murine Hepatic Transcriptional and Proteomic Responses to TCDD","volume":"284","author":"Prokopec","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"bqab050","DOI":"10.1210\/endocr\/bqab050","article-title":"Prolonged Low-Dose Dioxin Exposure Impairs Metabolic Adaptability to High-Fat Diet Feeding in Female but Not Male Mice","volume":"162","author":"Matteo","year":"2021","journal-title":"Endocrinology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"127841","DOI":"10.1016\/j.chemosphere.2020.127841","article-title":"Exposure to Pollutants Altered Glucocorticoid Signaling and Clock Gene Expression in Female Mice. Evidence of Tissue- and Sex-Specificity","volume":"262","author":"Vega","year":"2021","journal-title":"Chemosphere"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Sampaio, G.R., Guizellini, G.M., da Silva, S.A., de Almeida, A.P., Pinaffi-Langley, A.C.C., Rogero, M.M., de Camargo, A.C., and Torres, E.A.F.S. (2021). Polycyclic Aromatic Hydrocarbons in Foods: Biological Effects, Legislation, Occurrence, Analytical Methods, and Strategies to Reduce Their Formation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116010"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Goedtke, L., Sprenger, H., Hofmann, U., Schmidt, F.F., Hammer, H.S., Zanger, U.M., Poetz, O., Seidel, A., Braeuning, A., and Hessel-Pras, S. (2020). Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010372"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"105000","DOI":"10.1016\/j.envint.2019.105000","article-title":"Hepatotoxic Effects of Inhalation Exposure to Polycyclic Aromatic Hydrocarbons on Lipid Metabolism of C57BL\/6 Mice","volume":"134","author":"Li","year":"2020","journal-title":"Environ. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2019.10.010","article-title":"In Vitro and in Vivo Approaches for Identifying the Role of Aryl Hydrocarbon Receptor in the Development of Nonalcoholic Fatty Liver Disease","volume":"319","author":"Zhu","year":"2020","journal-title":"Toxicol. Lett."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kim, K., Melough, M.M., Vance, T.M., Noh, H., Koo, S.I., and Chun, O.K. (2018). Dietary Cadmium Intake and Sources in the US. Nutrients, 11.","DOI":"10.3390\/nu11010002"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"126134","DOI":"10.1016\/j.jhazmat.2021.126134","article-title":"Assessment of the Risks from Dietary Lead Exposure in China","volume":"418","author":"Zhang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1007\/s11356-013-2486-z","article-title":"Heavy Metals in the Environment: Sources, Interactions and Human Health","volume":"21","author":"Cinnirella","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e014215","DOI":"10.1136\/bmjopen-2016-014215","article-title":"Association between Soil Heavy Metals and Fatty Liver Disease in Men in Taiwan: A Cross Sectional Study","volume":"7","author":"Lin","year":"2017","journal-title":"BMJ Open"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Sadighara, P., Abedini, A.H., Irshad, N., Ghazi-Khansari, M., Esrafili, A., and Yousefi, M. (2023). Association Between Non-Alcoholic Fatty Liver Disease and Heavy Metal Exposure: A Systematic Review. Biol. Trace Elem. Res.","DOI":"10.1007\/s12011-023-03629-9"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3961\/jpmph.21.435","article-title":"Association Between Cadmium Exposure and Liver Function in Adults in the United States: A Cross-Sectional Study","volume":"54","author":"Hong","year":"2021","journal-title":"J. Prev. Med. Pub. Health"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"128947","DOI":"10.1016\/j.chemosphere.2020.128947","article-title":"Association between Environmental Exposure to Cadmium and Risk of Suspected Non-Alcoholic Fatty Liver Disease","volume":"266","author":"Park","year":"2021","journal-title":"Chemosphere"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10620-021-06869-8","article-title":"Cadmium Exposure in Young Adulthood Is Associated with Risk of Nonalcoholic Fatty Liver Disease in Midlife","volume":"67","author":"Li","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"39768","DOI":"10.1007\/s11356-022-18950-4","article-title":"Association between Urinary Cadmium Concentrations and Liver Function in Adolescents","volume":"29","author":"Xu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1000403","DOI":"10.3389\/fpubh.2022.1000403","article-title":"Lead Exposure as a Causative Factor for Metabolic Associated Fatty Liver Disease (MAFLD) and a Lead Exposure Related Nomogram for MAFLD Prevalence","volume":"10","author":"Yang","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"119780","DOI":"10.1016\/j.envpol.2022.119780","article-title":"Cadmium, Lead, and Mercury Mixtures Interact with Non-Alcoholic Fatty Liver Diseases","volume":"309","author":"Nguyen","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1133194","DOI":"10.3389\/fpubh.2023.1133194","article-title":"Associations of Metal Mixtures with Metabolic-Associated Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease: NHANES 2003\u20132018","volume":"11","author":"Xie","year":"2023","journal-title":"Front. Public Health"},{"key":"ref_133","first-page":"6","article-title":"Arsenic Exposure and Risk of Nonalcoholic Fatty Liver Disease (NAFLD) among U.S. Adolescents and Adults: An Association Modified by Race\/Ethnicity, NHANES 2005-2014","volume":"17","author":"Frediani","year":"2018","journal-title":"Environ. Health Glob. Access Sci. Source"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Genchi, G., Sinicropi, M.S., Lauria, G., Carocci, A., and Catalano, A. (2020). The Effects of Cadmium Toxicity. Int. J. Environ. Res. Public. Health, 17.","DOI":"10.3390\/ijerph17113782"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"113163","DOI":"10.1016\/j.ecoenv.2022.113163","article-title":"Association between Urine Metals and Liver Function Biomarkers in Northeast China: A Cross-Sectional Study","volume":"231","author":"Zhao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"114254","DOI":"10.1016\/j.ecoenv.2022.114254","article-title":"Cadmium Perturbed Lipid Profile and Induced Liver Dysfunction in Mice through Phosphatidylcholine Remodeling and Promoting Arachidonic Acid Synthesis and Metabolism","volume":"247","author":"Gu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"113306","DOI":"10.1016\/j.ecoenv.2022.113306","article-title":"Chronic Exposure to Low-Dose Cadmium Facilitated Nonalcoholic Steatohepatitis in Mice by Suppressing Fatty Acid Desaturation","volume":"233","author":"Zhu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1080\/00498254.2020.1858207","article-title":"Transcription Profiling of Cadmium-Exposed Livers Reveals Alteration of Lipid Metabolism and Predisposition to Hepatic Steatosis","volume":"51","author":"Ren","year":"2021","journal-title":"Xenobiotica Fate Foreign Compd. Biol. Syst."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"115855","DOI":"10.1016\/j.taap.2021.115855","article-title":"Whole Life Exposure to Low Dose Cadmium Alters Diet-Induced NAFLD","volume":"436","author":"Young","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1021\/acs.est.9b05131","article-title":"Inhibition of Mitochondrial Fatty Acid Oxidation Contributes to Development of Nonalcoholic Fatty Liver Disease Induced by Environmental Cadmium Exposure","volume":"53","author":"He","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1515\/reveh-2018-0037","article-title":"Sources of Lead Exposure in Various Countries","volume":"34","year":"2019","journal-title":"Rev. Environ. Health"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A New Definition for Metabolic Dysfunction-Associated Fatty Liver Disease: An International Expert Consensus Statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1289\/ehp.1002720","article-title":"Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in American Adults: NHANES 2003\u20132004","volume":"118","author":"Cave","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"110980","DOI":"10.1016\/j.envres.2021.110980","article-title":"Association between Cumulative Childhood Blood Lead Exposure and Hepatic Steatosis in Young Mexican Adults","volume":"196","author":"Cantoral","year":"2021","journal-title":"Environ. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1002\/1873-3468.13538","article-title":"Chronic Exposure to Pb2+ Perturbs ChREBP Transactivation and Coerces Hepatic Dyslipidemia","volume":"593","author":"Kamthan","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0014-2999(00)00473-8","article-title":"Lead Stimulates Intercellular Signalling between Hepatocytes and Kupffer Cells","volume":"401","author":"Milosevic","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"113257","DOI":"10.1016\/j.ecoenv.2022.113257","article-title":"Chronic Lead Exposure Induces Fatty Liver Disease Associated with the Variations of Gut Microbiota","volume":"232","author":"Wan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1021\/pr400719u","article-title":"Metabolomic Analysis of the Effects of Chronic Arsenic Exposure in a Mouse Model of Diet-Induced Fatty Liver Disease","volume":"13","author":"Shi","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"123034","DOI":"10.1016\/j.jhazmat.2020.123034","article-title":"Arsenic Induces Hepatic Insulin Resistance via MtROS-NLRP3 Inflammasome Pathway","volume":"399","author":"Jia","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41419-018-1004-0","article-title":"Taurine Attenuates Arsenic-Induced Pyroptosis and Nonalcoholic Steatohepatitis by Inhibiting the Autophagic-Inflammasomal Pathway","volume":"9","author":"Qiu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"109824","DOI":"10.1016\/j.envres.2020.109824","article-title":"Ferroptosis Mediated by the Interaction between Mfn2 and IRE\u03b1 Promotes Arsenic-Induced Nonalcoholic Steatohepatitis","volume":"188","author":"Wei","year":"2020","journal-title":"Environ. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1007\/s12011-022-03390-5","article-title":"Effects of Lead and Cadmium Combined Heavy Metals on Liver Function and Lipid Metabolism in Mice","volume":"201","author":"Chen","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Campanale, C., Massarelli, C., Savino, I., Locaputo, V., and Uricchio, V.F. (2020). A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health. Int. J. Environ. Res. Public. Health, 17.","DOI":"10.3390\/ijerph17041212"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.marpolbul.2018.11.022","article-title":"Microplastics: Finding a Consensus on the Definition","volume":"138","author":"Frias","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Yee, M.S.-L., Hii, L.-W., Looi, C.K., Lim, W.-M., Wong, S.-F., Kok, Y.-Y., Tan, B.-K., Wong, C.-Y., and Leong, C.-O. (2021). Impact of Microplastics and Nanoplastics on Human Health. Nanomaterials, 11.","DOI":"10.3390\/nano11020496"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"36046","DOI":"10.1007\/s11356-018-3508-7","article-title":"Occurrence, Sources, Human Health Impacts and Mitigation of Microplastic Pollution","volume":"25","author":"Karbalaei","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Yin, J., Ju, Y., Qian, H., Wang, J., Miao, X., Zhu, Y., Zhou, L., and Ye, L. (2022). Nanoplastics and Microplastics May Be Damaging Our Livers. Toxics, 10.","DOI":"10.3390\/toxics10100586"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"134455","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental Exposure to Microplastics: An Overview on Possible Human Health Effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envpol.2017.11.043","article-title":"Airborne Microplastics: Consequences to Human Health?","volume":"234","author":"Prata","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s13197-019-04138-1","article-title":"Microplastics: An Emerging Threat to Food Security and Human Health","volume":"57","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of Various Microplastics in Human Stool: A Prospective Case Series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"104147","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics Detected in Cirrhotic Liver Tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"EBioMedicine"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Auguet, T., Bertran, L., Barrientos-Riosalido, A., Fabregat, B., Villar, B., Aguilar, C., and Sabench, F. (2022). Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?. Int. J. Environ. Res. Public. Health, 19.","DOI":"10.3390\/ijerph192013495"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"027006","DOI":"10.1289\/EHP11072","article-title":"Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes","volume":"131","author":"Okamura","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/tox.23404","article-title":"Polystyrene Nanoplastics Potentiate the Development of Hepatic Fibrosis in High Fat Diet Fed Mice","volume":"37","author":"Li","year":"2022","journal-title":"Environ. Toxicol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"132607","DOI":"10.1016\/j.chemosphere.2021.132607","article-title":"Effects of Oral Administration of Polystyrene Nanoplastics on Plasma Glucose Metabolism in Mice","volume":"288","author":"Fan","year":"2022","journal-title":"Chemosphere"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"107349","DOI":"10.1016\/j.envint.2022.107349","article-title":"Polystyrene Nanoplastics Induce Profound Metabolic Shift in Human Cells as Revealed by Integrated Proteomic and Metabolomic Analysis","volume":"166","author":"Wang","year":"2022","journal-title":"Environ. Int."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"138180","DOI":"10.1016\/j.scitotenv.2020.138180","article-title":"Cytotoxic Effects of Polystyrene Nanoplastics with Different Surface Functionalization on Human HepG2 Cells","volume":"723","author":"He","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1021\/acs.est.2c03980","article-title":"Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells","volume":"56","author":"Lin","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"150328","DOI":"10.1016\/j.scitotenv.2021.150328","article-title":"Polystyrene Microplastics Induce Hepatotoxicity and Disrupt Lipid Metabolism in the Liver Organoids","volume":"806","author":"Cheng","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"126454","DOI":"10.1016\/j.jhazmat.2021.126454","article-title":"Dietary Polystyrene Nanoplastics Exposure Alters Liver Lipid Metabolism and Muscle Nutritional Quality in Carnivorous Marine Fish Large Yellow Croaker (Larimichthys Crocea)","volume":"419","author":"Lai","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"46687","DOI":"10.1038\/srep46687","article-title":"Tissue Accumulation of Microplastics in Mice and Biomarker Responses Suggest Widespread Health Risks of Exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"132944","DOI":"10.1016\/j.chemosphere.2021.132944","article-title":"Activation of Pyroptosis and Ferroptosis Is Involved in the Hepatotoxicity Induced by Polystyrene Microplastics in Mice","volume":"291","author":"Mu","year":"2022","journal-title":"Chemosphere"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Chen, L., Qi, M., Zhang, L., Yu, F., Tao, D., Xu, C., and Xu, S. (2023). Di(2-Ethylhexyl) Phthalate and Microplastics Cause Necroptosis and Apoptosis in Hepatocytes of Mice by Inducing Oxidative Stress. Environ. Toxicol.","DOI":"10.1002\/tox.23759"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"121233","DOI":"10.1016\/j.envpol.2023.121233","article-title":"Polystyrene Microplastics Induce Endoplasmic Reticulum Stress, Apoptosis and Inflammation by Disrupting the Gut Microbiota in Carp Intestines","volume":"323","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.molmed.2011.01.014","article-title":"Oxidative Stress, Inflammation and Carcinogenesis Are Controlled through the Pentose Phosphate Pathway by Transaldolase","volume":"17","author":"Perl","year":"2011","journal-title":"Trends Mol. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene Microplastics Induce Gut Microbiota Dysbiosis and Hepatic Lipid Metabolism Disorder in Mice","volume":"631\u2013632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"155984","DOI":"10.1016\/j.scitotenv.2022.155984","article-title":"Chronic Exposure to Polyvinyl Chloride Microplastics Induces Liver Injury and Gut Microbiota Dysbiosis Based on the Integration of Liver Transcriptome Profiles and Full-Length 16S RRNA Sequencing Data","volume":"839","author":"Chen","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"155937","DOI":"10.1016\/j.scitotenv.2022.155937","article-title":"Polystyrene Microplastic Exposure Induces Insulin Resistance in Mice via Dysbacteriosis and Pro-Inflammation","volume":"838","author":"Huang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"114105","DOI":"10.1016\/j.ecoenv.2022.114105","article-title":"Gender Difference in Hepatic AMPK Pathway Activated Lipid Metabolism Induced by Aged Polystyrene Microplastics Exposure","volume":"245","author":"Yang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"63185","DOI":"10.1007\/s11356-023-26565-6","article-title":"Reproductive and Metabolic Toxic Effects of Polystyrene Microplastics in Adult Female Wistar Rats: A Mechanistic Study","volume":"30","author":"Saeed","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"127629","DOI":"10.1016\/j.jhazmat.2021.127629","article-title":"Polystyrene Microplastics Induced Female Reproductive Toxicity in Mice","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"113024","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene Microplastics Cause Tissue Damages, Sex-Specific Reproductive Disruption and Transgenerational Effects in Marine Medaka (Oryzias Melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"153059","DOI":"10.1016\/j.tox.2021.153059","article-title":"Comparing the Effects of Polystyrene Microplastics Exposure on Reproduction and Fertility in Male and Female Mice","volume":"465","author":"Wei","year":"2022","journal-title":"Toxicology"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Thangavel, P., Park, D., and Lee, Y.-C. (2022). Recent Insights into Particulate Matter (PM2.5)-Mediated Toxicity in Humans: An Overview. Int. J. Environ. Res. Public. Health, 19.","DOI":"10.3390\/ijerph19127511"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"113378","DOI":"10.1016\/j.envres.2022.113378","article-title":"Effects of Air Pollution on Human Health\u2014Mechanistic Evidence Suggested by in Vitro and in Vivo Modelling","volume":"212","author":"Chen","year":"2022","journal-title":"Environ. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fpubh.2020.00014","article-title":"Environmental and Health Impacts of Air Pollution: A Review","volume":"8","author":"Manisalidis","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jhep.2021.10.016","article-title":"Exposure to Air Pollution Is Associated with an Increased Risk of Metabolic Dysfunction-Associated Fatty Liver Disease","volume":"76","author":"Guo","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gutjnl-2021-324364","article-title":"Long-Term Exposure to Fine Particulate Matter and Non-Alcoholic Fatty Liver Disease: A Prospective Cohort Study","volume":"71","author":"Sun","year":"2022","journal-title":"Gut"},{"key":"ref_190","first-page":"299","article-title":"Long-Term Exposure to Air Pollution and Incident Non-Alcoholic Fatty Liver Disease and Cirrhosis: A Cohort Study","volume":"43","author":"Li","year":"2023","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"119135","DOI":"10.1016\/j.lfs.2021.119135","article-title":"The Influence of PM2.5 Exposure on Non-Alcoholic Fatty Liver Disease","volume":"270","author":"Chen","year":"2021","journal-title":"Life Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.freeradbiomed.2018.11.016","article-title":"Prolonged PM2.5 Exposure Elevates Risk of Oxidative Stress-Driven Nonalcoholic Fatty Liver Disease by Triggering Increase of Dyslipidemia","volume":"130","author":"Xu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Ding, S., Yuan, C., Si, B., Wang, M., Da, S., Bai, L., and Wu, W. (2019). Combined Effects of Ambient Particulate Matter Exposure and a High-Fat Diet on Oxidative Stress and Steatohepatitis in Mice. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214680"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"113173","DOI":"10.1016\/j.ecoenv.2022.113173","article-title":"Real Ambient Particulate Matter-Induced Lipid Metabolism Disorder: Roles of Peroxisome Proliferators-Activated Receptor Alpha","volume":"231","author":"Xu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"17423","DOI":"10.1038\/s41598-019-53716-y","article-title":"Air Pollution-Derived Particulate Matter Dysregulates Hepatic Krebs Cycle, Glucose and Lipid Metabolism in Mice","volume":"9","author":"Rao","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"106099","DOI":"10.1016\/j.biocel.2021.106099","article-title":"Airborne Fine Particulate Matter in Japan Induces Lipid Synthesis and Inhibits Autophagy in HepG2 Cells","volume":"141","author":"Ogino","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/15476910903241704","article-title":"Kupffer Cell Activation by Ambient Air Particulate Matter Exposure May Exacerbate Non-Alcoholic Fatty Liver Disease","volume":"6","author":"Tan","year":"2009","journal-title":"J. Immunotoxicol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfr211","article-title":"Long-Term Exposure to Ambient Fine Particulate Pollution Induces Insulin Resistance and Mitochondrial Alteration in Adipose Tissue","volume":"124","author":"Xu","year":"2011","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"113342","DOI":"10.1016\/j.envpol.2019.113342","article-title":"PM2.5 Aggravates Diabetes via the Systemically Activated IL-6-Mediated STAT3\/SOCS3 Pathway in Rats\u2019 Liver","volume":"256","author":"Long","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"114562","DOI":"10.1016\/j.ecoenv.2023.114562","article-title":"Dissecting Contributions of Representative Heavy Metal Components in PM2.5 to Its Cytotoxicity","volume":"251","author":"Pan","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Xu, J., Zhang, W., Lu, Z., Zhang, F., and Ding, W. (2017). Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2\/JNK-Mediated Signaling Pathway. Int. J. Environ. Res. Public. Health, 14.","DOI":"10.3390\/ijerph14070787"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"C736","DOI":"10.1152\/ajpcell.00529.2009","article-title":"Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues","volume":"299","author":"Laing","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s13679-021-00431-3","article-title":"Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives","volume":"10","author":"Flessa","year":"2021","journal-title":"Curr. Obes. Rep."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Kish, L., Hotte, N., Kaplan, G.G., Vincent, R., Tso, R., G\u00e4nzle, M., Rioux, K.P., Thiesen, A., Barkema, H.W., and Wine, E. (2013). Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062220"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1743-8977-8-19","article-title":"Particulate Matter Air Pollution Causes Oxidant-Mediated Increase in Gut Permeability in Mice","volume":"8","author":"Mutlu","year":"2011","journal-title":"Part. Fibre Toxicol."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Ferro, D., Baratta, F., Pastori, D., Cocomello, N., Colantoni, A., Angelico, F., and Del Ben, M. (2020). New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress. Nutrients, 12.","DOI":"10.3390\/nu12092762"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The Role of the Gut Microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00018-019-03011-w","article-title":"The Links between the Gut Microbiome and Non-Alcoholic Fatty Liver Disease (NAFLD)","volume":"76","author":"Safari","year":"2019","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12989-020-00343-5","article-title":"Sex-Dependent Effects of Ambient PM2.5 Pollution on Insulin Sensitivity and Hepatic Lipid Metabolism in Mice","volume":"17","author":"Li","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"20581","DOI":"10.1007\/s11356-019-05383-9","article-title":"Ovariectomy Predisposes Female Rats to Fine Particulate Matter Exposure\u2019s Effects by Altering Metabolic, Oxidative, pro-Inflammatory, and Heat-Shock Protein Levels","volume":"26","author":"Friske","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jhep.2022.02.012","article-title":"The Negative Bidirectional Interaction between Climate Change and the Prevalence and Care of Liver Disease: A Joint BSG, BASL, EASL, and AASLD Commentary","volume":"76","author":"Donnelly","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1016\/S2542-5196(23)00003-7","article-title":"Mechanisms Underlying Food Insecurity in the Aftermath of Climate-Related Shocks: A Systematic Review","volume":"7","author":"Hadley","year":"2023","journal-title":"Lancet Planet. Health"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-021-00329-3","article-title":"Climate Change and Nutrition-Associated Diseases","volume":"7","author":"Fanzo","year":"2021","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1055\/a-1533-2861","article-title":"Climate Change and Obesity","volume":"53","author":"Koch","year":"2021","journal-title":"Horm. Metab. Res."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Krishnan, A., and Mou, X. (2021). A Brief Review of the Structure, Cytotoxicity, Synthesis, and Biodegradation of Microcystins. Water, 13.","DOI":"10.3390\/w13162147"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Chorus, I., Fastner, J., and Welker, M. (2021). Cyanobacteria and Cyanotoxins in a Changing Environment: Concepts, Controversies, Challenges. Water, 13.","DOI":"10.3390\/w13182463"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Bui, T., Dao, T.-S., Vo, T.-G., and L\u00fcrling, M. (2018). Warming Affects Growth Rates and Microcystin Production in Tropical Bloom-Forming Microcystis Strains. Toxins, 10.","DOI":"10.3390\/toxins10030123"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Lad, A., Breidenbach, J.D., Su, R.C., Murray, J., Kuang, R., Mascarenhas, A., Najjar, J., Patel, S., Hegde, P., and Youssef, M. (2022). As We Drink and Breathe: Adverse Health Effects of Microcystins and Other Harmful Algal Bloom Toxins in the Liver, Gut, Lungs and Beyond. Life, 12.","DOI":"10.3390\/life12030418"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Arman, T., and Clarke, J. (2021). Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins, 13.","DOI":"10.3390\/toxins13080537"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"106661","DOI":"10.1016\/j.envint.2021.106661","article-title":"Advances in the Toxicology Research of Microcystins Based on Omics Approaches","volume":"154","author":"Ma","year":"2021","journal-title":"Environ. Int."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"105648","DOI":"10.1016\/j.envint.2020.105648","article-title":"Long-Term Environmental Exposure to Microcystins Increases the Risk of Nonalcoholic Fatty Liver Disease in Humans: A Combined Fisher-Based Investigation and Murine Model Study","volume":"138","author":"Zhao","year":"2020","journal-title":"Environ. Int."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Lad, A., Su, R., Breidenbach, J., Stemmer, P., Carruthers, N., Sanchez, N., Khalaf, F., Zhang, S., Kleinhenz, A., and Dube, P. (2019). Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease. Toxins, 11.","DOI":"10.3390\/toxins11090486"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00204-016-1681-3","article-title":"Prolonged Exposure to Low-Dose Microcystin Induces Nonalcoholic Steatohepatitis in Mice: A Systems Toxicology Study","volume":"91","author":"He","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Arman, T., Lynch, K.D., Montonye, M.L., Goedken, M., and Clarke, J.D. (2019). Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats. Toxins, 11.","DOI":"10.3390\/toxins11070398"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jhazmat.2016.05.011","article-title":"Comprehensive Insights into Microcystin-LR Effects on Hepatic Lipid Metabolism Using Cross-Omics Technologies","volume":"315","author":"Zhang","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"106555","DOI":"10.1016\/j.envint.2021.106555","article-title":"Effects of Environmental Contaminants in Water Resources on Nonalcoholic Fatty Liver Disease","volume":"154","author":"Zheng","year":"2021","journal-title":"Environ. Int."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2019.03.002","article-title":"Nonalcoholic Fatty Liver Disease Alters Microcystin-LR Toxicokinetics and Acute Toxicity","volume":"162","author":"Clarke","year":"2019","journal-title":"Toxicon"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Mrdjen, I., Morse, M., Ruch, R., Knobloch, T., Choudhary, S., Weghorst, C., and Lee, J. (2018). Impact of Microcystin-LR on Liver Function Varies by Dose and Sex in Mice. Toxins, 10.","DOI":"10.3390\/toxins10110435"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/21623945.2018.1551689","article-title":"Brown Adipose Tissue and Glucose Homeostasis\u2014The Link between Climate Change and the Global Rise in Obesity and Diabetes","volume":"8","author":"Symonds","year":"2019","journal-title":"Adipocyte"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11154-016-9358-z","article-title":"The Effects of Indoor and Outdoor Temperature on Metabolic Rate and Adipose Tissue\u2014The Mississippi Perspective on the Obesity Epidemic","volume":"17","author":"Turner","year":"2016","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"e46404","DOI":"10.15252\/embr.201846404","article-title":"Brown Adipocyte Glucose Metabolism: A Heated Subject","volume":"19","author":"Hankir","year":"2018","journal-title":"EMBO Rep."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1111\/febs.16015","article-title":"Energy Metabolism in Brown Adipose Tissue","volume":"288","author":"Wang","year":"2021","journal-title":"FEBS J."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"100332","DOI":"10.1016\/j.xcrm.2021.100332","article-title":"Brown Adipose Tissue Is Associated with Healthier Body Fat Distribution and Metabolic Benefits Independent of Regional Adiposity","volume":"2","author":"Wibmer","year":"2021","journal-title":"Cell Rep. Med."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/21623945.2020.1870060","article-title":"Brown and Beige Adipose Tissue: A Novel Therapeutic Strategy for Obesity and Type 2 Diabetes Mellitus","volume":"10","author":"Cheng","year":"2021","journal-title":"Adipocyte"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"105219","DOI":"10.1016\/j.earlhumdev.2020.105219","article-title":"Gestational Diabetes, Environmental Temperature and Climate Factors\u2014From Epidemiological Evidence to Physiological Mechanisms","volume":"155","author":"Pace","year":"2021","journal-title":"Early Hum. Dev."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41574-021-00579-x","article-title":"Low Brown Adipose Tissue Activity Linked to NAFLD","volume":"17","author":"Greenhill","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"100397","DOI":"10.1016\/j.xcrm.2021.100397","article-title":"Lower Brown Adipose Tissue Activity Is Associated with Non-Alcoholic Fatty Liver Disease but Not Changes in the Gut Microbiota","volume":"2","author":"Ahmed","year":"2021","journal-title":"Cell Rep. Med."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/endrev\/bnz007","article-title":"Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism","volume":"41","author":"Scheele","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-021-09640-6","article-title":"The Endocrine Role of Brown Adipose Tissue: An Update on Actors and Actions","volume":"23","author":"Villarroya","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"111337","DOI":"10.1016\/j.mce.2021.111337","article-title":"The Good and the BAT of Metabolic Sex Differences in Thermogenic Human Adipose Tissue","volume":"533","author":"Keuper","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"652444","DOI":"10.3389\/fendo.2021.652444","article-title":"Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk","volume":"12","author":"Kaikaew","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"111365","DOI":"10.1016\/j.mce.2021.111365","article-title":"Sex Differences in Brown Adipose Tissue Activity and Cold-Induced Thermogenesis","volume":"534","author":"Herz","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Garc\u00eda, I., Trepiana, J., Fern\u00e1ndez-Quintela, A., Giralt, M., and Portillo, M.P. (2022). Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158250"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/oby.22698","article-title":"Sexual Dimorphisms in Adult Human Brown Adipose Tissue","volume":"28","author":"Fletcher","year":"2020","journal-title":"Obes. Silver Spring Md"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrendo.2013.203","article-title":"Energy Metabolism and Fertility\u2014A Balance Preserved for Female Health","volume":"10","author":"Benedusi","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Polycystic Ovary Syndrome","volume":"375","author":"McCartney","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic Ovary Syndrome","volume":"10","author":"Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Spremovi\u0107 Ra\u0111enovi\u0107, S., Pupovac, M., Andji\u0107, M., Bila, J., Sre\u0107kovi\u0107, S., Gudovi\u0107, A., Draga\u0161, B., and Radunovi\u0107, N. (2022). Prevalence, Risk Factors, and Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Women with Polycystic Ovary Syndrome (PCOS). Biomedicines, 10.","DOI":"10.3390\/biomedicines10010131"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/clinem\/dgab658","article-title":"Nonalcoholic Fatty Liver Disease in Women and Girls with Polycystic Ovary Syndrome","volume":"107","author":"Falzarano","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_250","first-page":"355","article-title":"Polycystic Ovary Syndrome (PCOS) Is Associated with NASH Severity and Advanced Fibrosis","volume":"40","author":"Sarkar","year":"2020","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"105829","DOI":"10.1016\/j.jsbmb.2021.105829","article-title":"Long-Term Androgen Excess Induces Insulin Resistance and Non-Alcoholic Fatty Liver Disease in PCOS-like Rats","volume":"208","author":"Cui","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s40618-017-0762-3","article-title":"Androgen Excess and Metabolic Disorders in Women with PCOS: Beyond the Body Mass Index","volume":"41","author":"Condorelli","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"bqac127","DOI":"10.1210\/endocr\/bqac127","article-title":"Androgen-Mediated Perturbation of the Hepatic Circadian System Through Epigenetic Modulation Promotes NAFLD in PCOS Mice","volume":"163","author":"Roy","year":"2022","journal-title":"Endocrinology"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11154-016-9326-7","article-title":"Polycystic Ovary Syndrome (PCOS) and Endocrine Disrupting Chemicals (EDCs)","volume":"16","author":"Palioura","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"106819","DOI":"10.1016\/j.envint.2021.106819","article-title":"Perfluoroalkyl Substances (PFAS) in Drinking Water and Risk for Polycystic Ovarian Syndrome, Uterine Leiomyoma, and Endometriosis: A Swedish Cohort Study","volume":"157","author":"Hammarstrand","year":"2021","journal-title":"Environ. Int."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"131495","DOI":"10.1016\/j.chemosphere.2021.131495","article-title":"The Relationship between Urinary Phthalate Metabolites and Polycystic Ovary Syndrome in Women Undergoing in Vitro Fertilization: Nested Case-Control Study","volume":"286","year":"2022","journal-title":"Chemosphere"},{"key":"ref_257","first-page":"64","article-title":"Associations between Blood Cadmium and Endocrine Features Related to PCOS-Phenotypes in Healthy Women of Reproductive Age: A Prospective Cohort Study","volume":"20","author":"Kim","year":"2021","journal-title":"Environ. Health Glob. Access Sci. Source"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.reprotox.2022.05.002","article-title":"Changes in Serum Heavy Metals in Polycystic Ovary Syndrome and Their Association with Endocrine, Lipid-Metabolism, Inflammatory Characteristics and Pregnancy Outcomes","volume":"111","author":"Zhang","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Lin, S.-Y., Yang, Y.-C., Chang, C.Y.-Y., Lin, C.-C., Hsu, W.-H., Ju, S.-W., Hsu, C.-Y., and Kao, C.-H. (2019). Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis. Int. J. Environ. Res. Public. Health, 16.","DOI":"10.3390\/ijerph16234816"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"22935","DOI":"10.1038\/s41598-021-02120-6","article-title":"Antioxidant Status in Relation to Heavy Metals Induced Oxidative Stress in Patients with Polycystic Ovarian Syndrome (PCOS)","volume":"11","author":"Abudawood","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhou, W., Shi, Y., Zhang, J., Cui, L., and Chen, Z.-J. (2020). Lifestyle and Environmental Contributions to Ovulatory Dysfunction in Women of Polycystic Ovary Syndrome. BMC Endocr. Disord., 20.","DOI":"10.1186\/s12902-020-0497-6"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/en.2017-00887","article-title":"Endocrine Disruptors and Developmental Origins of Nonalcoholic Fatty Liver Disease","volume":"159","author":"Katz","year":"2018","journal-title":"Endocrinology"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S2040174416000805","article-title":"Early Life Programming and the Risk of Non-Alcoholic Fatty Liver Disease","volume":"8","author":"Lynch","year":"2017","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10565-020-09535-3","article-title":"Gestational Bisphenol A Exposure Induces Fatty Liver Development in Male Offspring Mice through the Inhibition of HNF1b and Upregulation of PPAR\u03b3","volume":"37","author":"Long","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3389\/fendo.2019.00620","article-title":"Non-Alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated MTOR and TLR4\/NF-\u039aB Signaling Pathways in Offspring Rats","volume":"10","author":"Lin","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"087005","DOI":"10.1289\/EHP664","article-title":"Hepatic Lipid Accumulation and Nrf2 Expression Following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease","volume":"125","author":"Shimpi","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1007\/s11356-022-22246-y","article-title":"Perinatal Exposure to Environmental Endocrine Disruptor Bisphenol A Aggravates the Onset of Non-Alcoholic Fatty Liver Disease (NAFLD) in Weanling F1 Offspring of Obese Rats","volume":"30","author":"Dabeer","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/JOE-14-0356","article-title":"Perinatal Exposure to Bisphenol A Exacerbates Nonalcoholic Steatohepatitis-like Phenotype in Male Rat Offspring Fed on a High-Fat Diet","volume":"222","author":"Wei","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.taap.2015.02.021","article-title":"Developmental Bisphenol A (BPA) Exposure Leads to Sex-Specific Modification of Hepatic Gene Expression and Epigenome at Birth That May Exacerbate High-Fat Diet-Induced Hepatic Steatosis","volume":"284","author":"Strakovsky","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"131645","DOI":"10.1016\/j.chemosphere.2021.131645","article-title":"Gestational Exposure to High Fat Diets and Bisphenol A Alters Metabolic Outcomes in Dams and Offspring, but Produces Hepatic Steatosis Only in Dams","volume":"286","author":"Marchlewicz","year":"2022","journal-title":"Chemosphere"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.envpol.2018.12.053","article-title":"Effects of Triphenyl Phosphate Exposure during Fetal Development on Obesity and Metabolic Dysfunctions in Adult Mice: Impaired Lipid Metabolism and Intestinal Dysbiosis","volume":"246","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.1409501","article-title":"Effects of Arsenite Exposure during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Disease in Male Mice","volume":"124","author":"Ditzel","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.31483","article-title":"Prenatal Exposure to Perfluoroalkyl Substances Associated with Increased Susceptibility to Liver Injury in Children","volume":"72","author":"Stratakis","year":"2020","journal-title":"Hepatology"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/hep.31809","article-title":"In Utero Exposure to Mercury Is Associated with Increased Susceptibility to Liver Injury and Inflammation in Childhood","volume":"74","author":"Stratakis","year":"2021","journal-title":"Hepatology"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1097\/EE9.0000000000000153","article-title":"Prenatal and Childhood Exposure to Air Pollution and Traffic and the Risk of Liver Injury in European Children","volume":"5","author":"Garcia","year":"2021","journal-title":"Environ. Epidemiol."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Lo, E.K.K., Xu, J.-H., Zhan, Q., Zeng, Z., and El-Nezami, H. (2022). The Emerging Role of Branched-Chain Amino Acids in Liver Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061444"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"e159204","DOI":"10.1172\/jci.insight.159204","article-title":"Altered Branched-Chain \u03b1-Keto Acid Metabolism Is a Feature of NAFLD in Individuals with Severe Obesity","volume":"7","author":"Deleye","year":"2022","journal-title":"JCI Insight"},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"van den Berg, E.H., Flores-Guerrero, J.L., Gruppen, E.G., de Borst, M.H., Wolak-Dinsmore, J., Connelly, M.A., Bakker, S.J.L., and Dullaart, R.P.F. (2019). Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids. Nutrients, 11.","DOI":"10.3390\/nu11030705"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"e12739","DOI":"10.1111\/ijpo.12739","article-title":"A Branched-Chain Amino Acid-Based Metabolic Score Can Predict Liver Fat in Children and Adolescents with Severe Obesity","volume":"16","author":"Lischka","year":"2021","journal-title":"Pediatr. Obes."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"116306","DOI":"10.1016\/j.envpol.2020.116306","article-title":"Exposure to Nitenpyram during Pregnancy Causes Colonic Mucosal Damage and Non-Alcoholic Steatohepatitis in Mouse Offspring: The Role of Gut Microbiota","volume":"271","author":"Yan","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"138255","DOI":"10.1016\/j.chemosphere.2023.138255","article-title":"Effects of Polystyrene Nanoplastic Gestational Exposure on Mice","volume":"324","author":"Wang","year":"2023","journal-title":"Chemosphere"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"121054","DOI":"10.1016\/j.lfs.2022.121054","article-title":"Predisposed Obesity and Long-Term Metabolic Diseases from Maternal Exposure to Fine Particulate Matter (PM2.5)\u2014A Review of Its Effect and Potential Mechanisms","volume":"310","author":"Sun","year":"2022","journal-title":"Life Sci."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1073\/pnas.1902925116","article-title":"Adverse Organogenesis and Predisposed Long-Term Metabolic Syndrome from Prenatal Exposure to Fine Particulate Matter","volume":"116","author":"Wu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"Song, Y., Chen, L., Bennett, E., Wheeler, A.J., Southam, K., Yen, S., Johnston, F., and Zosky, G.R. (2023). Can Maternal Exposure to Air Pollution Affect Post-Natal Liver Development?. Toxics, 11.","DOI":"10.3390\/toxics11010061"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chemosphere.2019.03.185","article-title":"Exposure to Air Pollution during Pregnancy and Newborn Liver Function","volume":"226","author":"Pejhan","year":"2019","journal-title":"Chemosphere"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"113366","DOI":"10.1016\/j.envpol.2019.113366","article-title":"Prenatal Exposure to Diesel Exhaust PM2.5 Programmed Non-Alcoholic Fatty Liver Disease Differently in Adult Male Offspring of Mice Fed Normal Chow and a High-Fat Diet","volume":"255","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.31518","article-title":"Multiple Parallel Hits Hypothesis in Nonalcoholic Fatty Liver Disease: Revisited After a Decade","volume":"73","author":"Tilg","year":"2021","journal-title":"Hepatology"},{"key":"ref_288","doi-asserted-by":"crossref","unstructured":"Chen, H., Van Reyk, D., Oliveira, A., Chan, Y.L., Town, S.E., Rayner, B., Pollock, C.A., Saad, S., George, J., and Padula, M.P. (2022). Sex-Dependent Responses to Maternal Exposure to PM2.5 in the Offspring. Antioxidants, 11.","DOI":"10.3390\/antiox11112255"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/10\/2335\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:36:25Z","timestamp":1760124985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/10\/2335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":288,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["nu15102335"],"URL":"https:\/\/doi.org\/10.3390\/nu15102335","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}