{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:46:02Z","timestamp":1792449962433,"version":"4.5.0"},"reference-count":163,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biological and Biotechnological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/V014684\/1"],"award-info":[{"award-number":["BB\/V014684\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation\u2013contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and\/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.<\/jats:p>","DOI":"10.3390\/nu15102355","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:32:58Z","timestamp":1684391578000},"page":"2355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Magnesium Deficiency and Cardiometabolic Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-8364","authenticated-orcid":false,"given":"Remi","family":"Fritzen","sequence":"first","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Davies","sequence":"additional","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Veenhuizen","sequence":"additional","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-5041","authenticated-orcid":false,"given":"Matthew","family":"Campbell","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Sciences, University of Sunderland, Sunderland SR1 3DS, UK"},{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-1595","authenticated-orcid":false,"given":"Samantha J.","family":"Pitt","sequence":"additional","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi A.","family":"Ajjan","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4580-1840","authenticated-orcid":false,"given":"Alan J.","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: Implications for health and disease","volume":"95","author":"Hoenderop","year":"2015","journal-title":"Physiol. 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