{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:03:08Z","timestamp":1775714588573,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T00:00:00Z","timestamp":1684627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tanuma Green House Foundation"},{"name":"Daiichi Sankyo Co."},{"name":"Pfizer Japan Inc."},{"name":"Bayer Yakuhin Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Several cohort studies have reported that the Japanese diet is associated with reduced cardiovascular disease mortality. However, the results were not always consistent, and most of those studies conducted dietary surveys around 1990. We investigated the association between the Japanese diet and coronary artery disease (CAD) in 802 patients undergoing coronary angiography. The Japanese diet score was defined as the sum of scores of the intakes of fish, soy products, vegetables, seaweed, fruits, and green tea. CAD was found in 511 patients, of whom 173 had myocardial infarction (MI). Intakes of fish, soy products, vegetables, seaweed, fruits, and green tea were lower in patients with CAD, especially in those with MI, than in those without CAD. As a result, the Japanese diet score was significantly lower in patients with CAD than in those without CAD (p &lt; 0.001). To clarify the association between the Japanese diet and CAD, the 802 study patients were divided into three tertiles by the Japanese diet score. The proportion of CAD decreased with the Japanese diet score, reaching 72% in patients at T1 (lowest score), 63% at T2, and 55% at T3 (highest) (p &lt; 0.05). The proportion of MI also decreased with the Japanese diet score, reaching 25% at T1, 24% at T2, and 15% at T3 (p &lt; 0.05). In a multivariate analysis, compared with T1, the adjusted odds ratios for CAD and MI were 0.41 (95% confidence interval [CI]: 0.26\u20130.63) and 0.61 (95% CI: 0.38\u20130.99) for T3, respectively. Thus, the Japanese diet was found to be inversely associated with CAD in Japanese patients undergoing coronary angiography.<\/jats:p>","DOI":"10.3390\/nu15102406","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T02:00:27Z","timestamp":1684720827000},"page":"2406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between the Japanese Diet and Coronary Artery Disease in Patients Undergoing Coronary Angiography"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-1446","authenticated-orcid":false,"given":"Yukihiko","family":"Momiyama","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo 152-8902, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, Faculty of Agriculture, Setsunan University, Osaka 573-0101, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Saita","sequence":"additional","affiliation":[{"name":"Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo 152-8902, Japan"},{"name":"Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Faculty of Regional Design, Utsunomiya University, Tochigi 321-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Ochanomizu University, Tokyo 112-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.5551\/jat.8193","article-title":"Japanese dietary lifestyle and cardiovascular disease","volume":"18","author":"Tada","year":"2011","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41430-020-0677-5","article-title":"Why has Japan become the world\u2019s most long-lived country: Insights from a food and nutrition perspective","volume":"75","author":"Tsugane","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/ajcn\/26.6.616","article-title":"Changes in serum cholesterol and coronary heart disease mortality associated with changes in the postwar Japanese diet","volume":"26","author":"Wen","year":"1973","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3177\/jnsv.64.129","article-title":"Characteristics of the Japanese diet described in epidemiologic publications: A qualitative systematic review","volume":"64","author":"Suzuki","year":"2018","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/ije\/dym005","article-title":"Dietary patterns and cardiovascular disease mortality in Japan: A prospective cohort study","volume":"36","author":"Shimazu","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5551\/jat.36780","article-title":"Effects of a Japan diet intake program on metabolic parameters in middle-aged men","volume":"24","author":"Maruyama","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00394-020-02330-0","article-title":"Association between adherence to the Japanese diet and all-cause and cause-specific mortality: The Japan Public Health Center-based prospective study","volume":"60","author":"Matsuyama","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Shirota, M., Watanabe, N., Suzuki, M., and Kobori, M. (2022). Japanese-style diet and cardiovascular disease mortality: A systematic review and meta-analysis of prospective cohort studies. Nutrients, 14.","DOI":"10.3390\/nu14102008"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Murakami, K., Livingstone, M.B.E., and Sasaki, S. (2018). Thirteen-year trends in dietary patterns among Japanese adults in the National Health and Nutrition Survey 2003\u20132015: Continuous Westernization of the Japanese diet. Nutrients, 10.","DOI":"10.3390\/nu10080994"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.atherosclerosis.2018.06.877","article-title":"Adherence to Mediterranean diet, high-sensitive C-reactive protein, and severity of coronary artery disease: Contemporary data from the INTERCATH cohort","volume":"275","author":"Waldeyer","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0003319717721603","article-title":"Western dietary pattern Is associated with severe coronary artery disease","volume":"69","author":"Oikonomou","year":"2018","journal-title":"Angiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1047-2797(00)00066-1","article-title":"Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women","volume":"10","author":"Sasazuki","year":"2000","journal-title":"Ann. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1253\/circj.68.665","article-title":"Effects of green tea intake on the development of coronary artery disease","volume":"68","author":"Sano","year":"2004","journal-title":"Circ. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1253\/jcj.65.200","article-title":"Case-control study of nonfatal myocardial infarction in relation to selected foods in Japanese men and women","volume":"65","author":"Sasazuki","year":"2001","journal-title":"Jpn. Circ. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3177\/jnsv.66.237","article-title":"Associations between green tea consumption and coffee consumption and the prevalence of coronary artery disease","volume":"66","author":"Kishimoto","year":"2020","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0002-9149(02)02787-X","article-title":"Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease","volume":"90","author":"Hirano","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"ref_17","first-page":"7","article-title":"Antioxidant beverages: Green tea intake and coronary artery disease","volume":"8","author":"Ohmori","year":"2014","journal-title":"Clin. Med. Insights Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3945\/ajcn.114.087551","article-title":"Rice consumption and risk of cardiovascular disease: Results from a pooled analysis of 3 U.S. cohorts","volume":"101","author":"Muraki","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3945\/ajcn.113.079038","article-title":"Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women: A large population-based, prospective cohort study","volume":"100","author":"Eshak","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00394-017-1582-0","article-title":"Mediterranean diet and cardiovascular disease: A systematic review and meta-analysis of observational studies","volume":"58","author":"Rosato","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","article-title":"Adherence to a Mediterranean diet and survival in a Greek population","volume":"348","author":"Trichopoulou","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Pant, A., Gribbin, S., McIntyre, D., Trivedi, R., Marschner, S., Laranjo, L., Mamas, M.A., Flood, V., Chow, C.K., and Zaman, S. (2023). Primary prevention of cardiovascular disease in women with a Mediterranean diet: Systematic review and meta-analysis. Heart, Available online: https:\/\/heart.bmj.com\/content\/early\/2023\/02\/14\/heartjnl-2022-321930.abstract.","DOI":"10.1136\/heartjnl-2022-321930"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cca.2011.04.038","article-title":"Coronary heart disease prevention: Nutrients, foods, and dietary patterns","volume":"412","author":"Bhupathiraju","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/advances\/nmaa029","article-title":"Fish consumption and the risk of chronic disease: An umbrella review of meta-analyses of prospective cohort studies","volume":"11","author":"Jayedi","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e017728","DOI":"10.1161\/JAHA.120.017728","article-title":"Relation of different fruit and vegetable sources with incident cardiovascular outcomes: A systematic review and meta-analysis of prospective cohort studies","volume":"9","author":"Zurbau","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/S000711451800154X","article-title":"The Japanese food score and risk of all-cause, CVD and cancer mortality: The Japan Collaborative Cohort study","volume":"120","author":"Okada","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1475-2891-9-70","article-title":"Nutritional related cardiovascular risk factors in patients with coronary artery disease in Iran: A case-control study","volume":"9","author":"Amani","year":"2010","journal-title":"Nutr. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s40200-018-0362-6","article-title":"Coronary artery stenosis and associations with indicators of anthropometric and diet in patients undergoing coronary angiography","volume":"17","author":"Gerami","year":"2018","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.21101\/cejph.a6149","article-title":"Fruit and vegetable consumption and cardiovascular diseases among Jordanians: A case-control study","volume":"28","author":"Tayyem","year":"2020","journal-title":"Cent. Eur. J. Public Health."},{"key":"ref_30","first-page":"599","article-title":"Major dietary patterns relationship with severity of coronary artery disease in Gaza-Strip, Palestine: A cross-sectional study","volume":"31","author":"Kuhail","year":"2021","journal-title":"Ethiop. J. Health Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/ajcn\/80.3.626","article-title":"Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease","volume":"80","author":"Lichtenstein","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1475-2891-12-143","article-title":"Use of food frequency questionnaire to assess relationships between dietary habits and cardiovascular risk factors in NESCAV study: Validation with biomarkers","volume":"12","author":"Sauvageot","year":"2013","journal-title":"Nutr. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.2188\/jea.15.S9","article-title":"Reproducibility and validity of a self-administered food frequency questionnaire used in the JACC study","volume":"15","author":"Date","year":"2005","journal-title":"J. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.nut.2019.03.014","article-title":"Effect of adherence to Mediterranean diet on first ST-elevation myocardial infarction: Insights from multiethnic case-control study","volume":"65","author":"Scarano","year":"2019","journal-title":"Nutrition"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/10\/2406\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:39:31Z","timestamp":1760125171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/10\/2406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,21]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["nu15102406"],"URL":"https:\/\/doi.org\/10.3390\/nu15102406","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,21]]}}}