{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:28:30Z","timestamp":1791048510058,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Education, Science, Sports and Culture, Grant- in- Aid for Scientific research, 2021\u20132023","award":["21K09473"],"award-info":[{"award-number":["21K09473"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The relationship between weight gain during pregnancy and the onset of hypertensive disorders of pregnancy in women with pre-pregnancy obesity remains unclear. We examined the effects of weight gain during pregnancy on hypertensive disorders of pregnancy among women with pre-pregnancy body mass index (BMI) \u2265 25.0 kg\/m2. This multicenter retrospective cohort study included nullipara women who delivered at two units in Japan between 1 January 2013, and 31 December 2020. Singleton primipara (n = 3040) were categorized into two pre-pregnancy BMI groups: 25.0\u2013&lt;30.0, and \u226530.0 kg\/m2. Using multiple logistic regression analyses (reported as adjusted odds ratio and 95% confidence interval), gestational weight gain effects on overall hypertensive disorders of pregnancy, gestational hypertension, and pre-eclampsia were determined. Gestational weight gain increased hypertensive disorders of pregnancy (1.09, 1.03\u20131.16, p &lt; 0.05) and pre-eclampsia risk (1.10, 1.01\u20131.20, p &lt; 0.05) among the BMI 25.0\u2013&lt;30.0 kg\/m2 group and hypertensive disorders of pregnancy risk among the \u226530.0 kg\/m2 group (1.07, 1.00\u20131.05, p &lt; 0.05). Using receiver operating characteristic curve analyses, among the BMI 25.0\u2013&lt;30.0 kg\/m2 group, for hypertensive disorders of pregnancy (area under the curve [AUC], 0.63, p &lt; 0.05) and pre-eclampsia (AUC, 0.62; p &lt; 0.05), the weight gain cut-off was 10.5 and 10.6 kg, with sensitivity\/specificity of 0.47\/0.73 and 0.50\/0.73, respectively. For the BMI \u226530.0 kg\/m2 group (AUC, 0.63, p &lt; 0.05), the cut-off was 3.5 kg (sensitivity\/specificity, 0.75\/0.49). The optimal gestational weight gain for reducing hypertensive disorders of pregnancy among women with a pre-pregnancy BMI &gt; 25 kg\/m2 may facilitate personalized pre-conception counseling among women with obesity.<\/jats:p>","DOI":"10.3390\/nu15112428","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:00:02Z","timestamp":1684825202000},"page":"2428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association between Gestational Weight Gain and Risk of Hypertensive Disorders of Pregnancy among Women with Obesity: A Multicenter Retrospective Cohort Study in Japan"],"prefix":"10.3390","volume":"15","author":[{"given":"Momoka","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7782-3396","authenticated-orcid":false,"given":"Hyo","family":"Kyozuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Sugeno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-117X","authenticated-orcid":false,"given":"Tsuyoshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University, 1, Hikarigaoka, Fukushima City 961-8141, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Hiraiwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Iwase General Hospital, 20, Kitamachi, Sukagawa City 962-8503, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toma","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University, 1, Hikarigaoka, Fukushima City 961-8141, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University, 1, Hikarigaoka, Fukushima City 961-8141, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiya","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University, 1, Hikarigaoka, Fukushima City 961-8141, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ohta Nisinouchi Hospital, 2-5-20, Nishinouchi, Koriyama City 963-8558, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1620\/tjem.246.27","article-title":"The Japan Environment and Children\u2019s Study (JECS) in Fukushima Prefecture: Pregnancy outcome after the Great East Japan Earthquake","volume":"246","author":"Kyozuka","year":"2018","journal-title":"Tohoku J. 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