{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:47Z","timestamp":1790621027730,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Takeda group of companies","award":["IIR-FRA-001392"],"award-info":[{"award-number":["IIR-FRA-001392"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Teduglutide, a GLP-2 analogue, has been available in France since 2015 to treat short-bowel-syndrome (SBS)-associated chronic intestinal failure (CIF) but it remains very expensive. No real-life data on the number of potential candidates are available. The aim of this real-life study was to assess teduglutide initiation and outcomes in SBS-CIF patients. All SBS-CIF patients cared for in an expert home parenteral support (PS) center between 2015 and 2020 were retrospectively included. Patients were divided into two subpopulations: prevalent patients, already cared for in the center before 2015, and incident patients, whose follow-up started between 2015 and 2020. A total of 331 SBS-CIF patients were included in the study (156 prevalent and 175 incident patients). Teduglutide was initiated in 56 patients (16.9% of the cohort); in 27.9% of prevalent patients and in 8.0% of incident patients, with a mean annual rate of 4.3% and 2.5%, respectively. Teduglutide allowed a reduction in the PS volume by 60% (IQR: 40\u2013100), with a significantly higher reduction in incident versus prevalent patients (p = 0.02). The two- and five-year treatment retention rates were 82% and 64%. Among untreated patients, 50 (18.2%) were considered ineligible for teduglutide for non-medical reasons. More than 25% of prevalent SBS patients were treated with teduglutide compared to 8% of incident patients. The treatment retention rate was &gt;80% at 2 years, which could be explained by a careful selection of patients. Furthermore, this real-life study confirmed the long-term efficacy of teduglutide and showed a better response to teduglutide in incident patients, suggesting a benefit in early treatment.<\/jats:p>","DOI":"10.3390\/nu15112448","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:00:55Z","timestamp":1684980055000},"page":"2448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Post-Marketing Use of Teduglutide in a Large Cohort of Adults with Short Bowel Syndrome-Associated Chronic Intestinal Failure: Evolution and Outcomes"],"prefix":"10.3390","volume":"15","author":[{"given":"Brune","family":"de Dreuille","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, H\u00f4pital Beaujon (AP-HP), 92110 Clichy, France"},{"name":"Inserm UMR 1149, Centre de Recherche sur l\u2019Inflammation, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, H\u00f4pital Beaujon (AP-HP), 92110 Clichy, France"},{"name":"Inserm UMR 1148, Laboratoire de Recherche Vasculaire Translationnelle, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bataille","sequence":"additional","affiliation":[{"name":"Pharmacy Department, H\u00f4pital Beaujon (AP-HP), 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mailhat","sequence":"additional","affiliation":[{"name":"GETAID (Groupe d\u2019\u00c9tude Th\u00e9rapeutique des Affections Inflammatoires du Tube Digestif), 75009 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Billiauws","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, H\u00f4pital Beaujon (AP-HP), 92110 Clichy, France"},{"name":"Inserm UMR 1149, Centre de Recherche sur l\u2019Inflammation, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-4585","authenticated-orcid":false,"given":"Maude","family":"Le Gall","sequence":"additional","affiliation":[{"name":"Inserm UMR 1149, Centre de Recherche sur l\u2019Inflammation, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, H\u00f4pital Beaujon (AP-HP), 92110 Clichy, France"},{"name":"Inserm UMR 1149, Centre de Recherche sur l\u2019Inflammation, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.clnu.2018.07.036","article-title":"Intestinal failure in adults: Recommendations from the ESPEN expert groups","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin. 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