{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:57:08Z","timestamp":1783360628452,"version":"3.54.6"},"reference-count":99,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Neurodegenerative diseases are characterized by neuronal dysfunction and death. Studies suggest that some seed extracts have a neuroprotective effect. Considering the increased incidence of these diseases and the need for new effective therapies with fewer side effects, this review aimed to assess the evidence of the efficacy and safety of seed extracts in experimental models of neurodegeneration. Material and Method: The search was carried out through studies published between 2000 and 2021 in Science Direct, PubMed, Scientific Electronic Library Online (SciELO), and Latin American Literature in Health Sciences (LILACS) databases, in which the effects of seed extracts in in vitro and in vivo experimental models of neurodegeneration were investigated. Based on the eligibility criteria, 47 studies were selected for this review. Results: In the in vitro models, the neuroprotection of the seed extracts was a result of their antioxidant, anti-inflammatory, and anti-apoptotic properties. In the in vivo models, neuroprotection resulted from the antioxidant and anti-inflammatory properties, a decrease in motor deficits, an improvement in learning and memory, as well as the increased release of neurotransmitters. The results show promise for the future of clinical research on new therapies for neurodegenerative diseases. However, the studies are still limited, which does not allow us to extrapolate the results to human beings with ND. Conclusions: Therefore, clinical trials are needed in order to prove the results of the in vitro and in vivo studies, as well as to assess the ideal, safe, and effective dose of these seed extracts in patients with neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/nu15112502","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:17:33Z","timestamp":1685204253000},"page":"2502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies"],"prefix":"10.3390","volume":"15","author":[{"given":"Gabriella Mendes","family":"Duarte","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Emanoel Alves","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Graduating in Pharmacy, Health School, Potiguar University (UnP), Mossor\u00f3 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Matheus Ca\u00e9","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Graduated in Nutrition, Health School, Potiguar University (UnP), Mossor\u00f3 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Idalina Neta","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Department of Biomedical Sciences, Faculty of Health Sciences, State University of Rio Grande do Norte (UERN), Mossor\u00f3 59610-210, Brazil"},{"name":"Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, State University of Rio Grande do Norte (UERN), Mossor\u00f3 59610-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e1lia Cinthia Meneses","family":"do Rego","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irami","family":"Ara\u00fajo Filho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"},{"name":"Medical School, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"},{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59010-180, Brazil"},{"name":"Department of Surgical, Federal University of Rio Grande do Norte, Natal 59010-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Irochima","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"},{"name":"Medical School, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Pereira","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Ney","family":"Cobucci","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"},{"name":"Medical School, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"},{"name":"Department of Surgical, Federal University of Rio Grande do Norte, Natal 59010-180, Brazil"},{"name":"Graduate Program in Science Applied to Women\u2019s Health, Medical School, Federal University of Rio Grande do Norte, Natal 59010-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto Pierdon\u00e1","family":"Guzen","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil"},{"name":"Postgraduate Program in Physiological Sciences, Department of Biomedical Sciences, Faculty of Health Sciences, State University of Rio Grande do Norte (UERN), Mossor\u00f3 59610-210, Brazil"},{"name":"Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, State University of Rio Grande do Norte (UERN), Mossor\u00f3 59610-210, Brazil"},{"name":"Postgraduate Program in Health and Society, Department of Biomedical Sciences, Faculty of Health Sciences, State University of Rio Grande do Norte (UERN), Mossor\u00f3 59610-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev-genet-110711-155524","article-title":"Biology and genetics of prions causing neurodegeneration","volume":"47","author":"Prusiner","year":"2013","journal-title":"Annu. 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