{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:42:06Z","timestamp":1790343726355,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Fundamental Research Grant Scheme (FRGS) of the Ministry of Higher Education (MOHE), Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2019\/SKK05\/MUSM\/03\/1"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK05\/MUSM\/03\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Fundamental Research Grant Scheme (FRGS) of the Ministry of Higher Education (MOHE), Malaysia","doi-asserted-by":"publisher","award":["PLT-000030"],"award-info":[{"award-number":["PLT-000030"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tropical Medicine and Biology (TMB) Platform, Monash University Malaysia","award":["FRGS\/1\/2019\/SKK05\/MUSM\/03\/1"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK05\/MUSM\/03\/1"]}]},{"name":"Tropical Medicine and Biology (TMB) Platform, Monash University Malaysia","award":["PLT-000030"],"award-info":[{"award-number":["PLT-000030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Geraniin, an ellagitannin, has shown a potent blood pressure-lowering effect in vivo. Therefore, this study aims to further characterize the ability of geraniin to attenuate hypertensive vascular dysfunction, a key feature of cardiovascular disease (CVD) development. Hypertension was induced in male Sprague-Dawley rats through feeding a high-fat diet (HFD) for eight weeks, followed by oral administration of 25 mg\/kg\/day geraniin for four weeks. The parameters of vascular dysfunction such as the structure and function of blood vessels as well as the vascular oxidative stress and inflammation were evaluated. The outcomes of geraniin-treated rats were compared with those of untreated rats on either a normal diet (ND) or HFD and with HFD-fed rats treated with captopril (40 mg\/kg\/day). We found that geraniin supplementation effectively ameliorated HFD-induced hypertension and abnormal remodelling of the thoracic aorta by suppressing excessive vascular superoxide (O2\u2212) radical generation and overexpression of pro-inflammatory mediators in the circulating leukocytes. Furthermore, compared to the ND-fed rats, geraniin also independently promoted the significant enlargement of the thoracic aortic lumen for blood pressure reduction. Notably, the vascular benefits of geraniin were comparable to that of captopril. Collectively, these data suggest that geraniin can mitigate hypertensive vascular remodelling caused by overnutrition, which potentially abrogates the further development of CVDs.<\/jats:p>","DOI":"10.3390\/nu15122696","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T08:37:33Z","timestamp":1686299853000},"page":"2696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4454-0477","authenticated-orcid":false,"given":"Boon Hee","family":"Goh","sequence":"first","affiliation":[{"name":"School of Science, Monash University Malaysia, Bandar Sunway 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-7872","authenticated-orcid":false,"given":"Hong Sheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637551, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pricilla Tracy A\/P A.","family":"Alexandra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Segi University, Kuala Lumpur 50010, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7818-3922","authenticated-orcid":false,"given":"Kang-Nee","family":"Ting","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Malaysia Campus, Semenyih 43500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-8241","authenticated-orcid":false,"given":"Uma Devi","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"Jeffrey Cheah School of Medicine and Health Science, Monash University Malaysia, Subang Jaya 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joash Ban Lee","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Science, Monash University Malaysia, Bandar Sunway 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023, April 01). 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