{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:29:34Z","timestamp":1781940574899,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Council","award":["BR 1704\/6-1"],"award-info":[{"award-number":["BR 1704\/6-1"]}]},{"name":"German Research Council","award":["BR 1704\/6-3"],"award-info":[{"award-number":["BR 1704\/6-3"]}]},{"name":"German Research Council","award":["BR 1704\/6-4"],"award-info":[{"award-number":["BR 1704\/6-4"]}]},{"name":"German Research Council","award":["CH 117\/1-1"],"award-info":[{"award-number":["CH 117\/1-1"]}]},{"name":"German Research Council","award":["HO 5117\/2-1"],"award-info":[{"award-number":["HO 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2270\/8-1"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["BR 1704\/17-1"],"award-info":[{"award-number":["BR 1704\/17-1"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["01KH0404"],"award-info":[{"award-number":["01KH0404"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["01ER0814"],"award-info":[{"award-number":["01ER0814"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["01ER0815"],"award-info":[{"award-number":["01ER0815"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["01ER1505A"],"award-info":[{"award-number":["01ER1505A"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["01ER1505B"],"award-info":[{"award-number":["01ER1505B"]}]},{"name":"Interdisciplinary Research Program of the National Centre for Tumour Diseases (NCT), Germany, and the German Federal Ministry of Education and Research","award":["01KD2104A"],"award-info":[{"award-number":["01KD2104A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>According to recent evidence, the prognostic value of Vitamin D (VitD) status for colorectal cancer (CRC) patients might be confined to patients with the GG genotype of Cdx2, a functional polymorphism of the VitD receptor gene. We aimed to validate these findings in a cohort of CRC patients. Post-operative serum 25-hydroxyvitamin D concentration was determined by mass spectrometry and Cdx2 genotyping was performed from blood or buccal swabs using standard methods. Joint associations of VitD status and Cdx2 with overall survival (OS), CRC-specific survival (CSS), recurrence-free survival (RFS), and disease-free survival (DFS) were assessed using Cox regression. For patients with GG genotype, adjusted hazard ratios (95% confidence interval) for the associations of sufficient compared with deficient VitD were 0.63 (0.50\u20130.78), 0.68 (0.50\u20130.90), 0.66 (0.51\u20130.86), and 0.62 (0.50\u20130.77) for OS, CSS, RFS, and DFS, respectively. These associations were weaker and not statistically significant for the AA\/AG genotype. Interaction between VitD status and genotype did not reach statistical significance. VitD deficiency is an independent predictor of poorer survival, particularly for the GG Cdx2 carriers, suggesting a potential role of VitD supplementation according to VitD status and genotype, which should be evaluated in randomised trials.<\/jats:p>","DOI":"10.3390\/nu15122717","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T03:02:27Z","timestamp":1686538947000},"page":"2717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin D Status, Cdx2 Genotype, and Colorectal Cancer Survival: Population-Based Patient Cohort"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-6315","authenticated-orcid":false,"given":"Tafirenyika","family":"Gwenzi","sequence":"first","affiliation":[{"name":"Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"},{"name":"Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-3492","authenticated-orcid":false,"given":"Petra","family":"Schrotz-King","sequence":"additional","affiliation":[{"name":"Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-4521","authenticated-orcid":false,"given":"Ben","family":"Sch\u00f6ttker","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-1572","authenticated-orcid":false,"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"},{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"},{"name":"Network Aging Research, Heidelberg University, Bergheimer Stra\u00dfe 20, 69115 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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