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However, its effect on ulcerative colitis is unknown. This study explores the impact of Ancientino on colitis caused by dextran sulfate sodium (DSS) and its mechanisms. Data analyses showed that Ancientino alleviated bodyweight loss, colon shortening and injury, and disease activity index (DAI) score, regulated levels of inflammatory factors (tumor necrosis factor-alpha (TNF-\u03b1), interleukin-10 (IL-10), interleukin-1 beta (IL-1\u03b2), and interleukin 6 (IL-6)), reduced intestinal permeability (d-lactate and endotoxin), fluorescein isothiocyanate\u2013dextran (FITC-dextran), and diamine oxidase (DAO), repaired colonic function (ZO-1 and occludin), and suppressed oxidative stress (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA)) in vivo and in vitro. In short, this study demonstrated that Ancientino alleviates colitis and exerts an anticolitis effect by reducing inflammatory response, suppressing oxidative stress, and repairing intestinal barrier function. Thus, Ancientino may be an effective therapeutic dietary resource for ulcerative colitis.<\/jats:p>","DOI":"10.3390\/nu15122798","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T01:59:30Z","timestamp":1687226370000},"page":"2798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-4154","authenticated-orcid":false,"given":"Meng","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biomedical Industry, Guilin Medical University, Guilin 541199, China"},{"name":"Industrial Technology Research Institute, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0263-810X","authenticated-orcid":false,"given":"Guoqiang","family":"Guan","sequence":"additional","affiliation":[{"name":"School of Biomedical Industry, Guilin Medical University, Guilin 541199, China"},{"name":"Industrial Technology Research Institute, Guilin Medical University, Guilin 541199, China"},{"name":"School of Pharmacy, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-8041","authenticated-orcid":false,"given":"Yizhun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, China"},{"name":"State Key Laboratory of Quality Research in Chinese Medicine, School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, China"},{"name":"School of Biomedical Industry, Guilin Medical University, Guilin 541199, China"},{"name":"Industrial Technology Research Institute, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and risk factors for IBD","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. 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