{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:34:35Z","timestamp":1792596875413,"version":"4.5.0"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pancreatico-duodenectomy (PD) includes resection of the duodenum and use of the proximal jejunum in a blind loop, thus reducing the absorptive capacity for vitamins and minerals. Several studies have analysed the frequency of micronutrient deficiencies, but there is a paucity of data on those taking routine supplements. A retrospective review of medical notes was undertaken on 548 patients under long-term follow-up following PD in a tertiary hepato-pancreatico-biliary centre. Data were available on 205 patients from 1\u201314 years following PD, and deficiencies were identified as follows: vitamin A (3%), vitamin D (46%), vitamin E (2%), iron (42%), iron-deficiency anaemia (21%), selenium (3%), magnesium (6%), copper (1%), and zinc (44%). Elevated parathyroid hormone was present in 11% of cases. There was no significant difference over time (p &gt; 0.05). Routine supplementation with a vitamin and mineral supplement did appear to reduce the incidence of biochemical deficiency in vitamin A, vitamin E, and selenium compared to published data. However, iron, vitamin D, and zinc deficiencies were prevalent despite supplementation and require surveillance.<\/jats:p>","DOI":"10.3390\/nu15122804","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T01:59:30Z","timestamp":1687226370000},"page":"2804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Do Patients Benefit from Micronutrient Supplementation following Pancreatico-Duodenectomy?"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-9993","authenticated-orcid":false,"given":"Mary E.","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Royal Surrey Hospital, Guildford GU2 7XX, UK"},{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7NX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-9866","authenticated-orcid":false,"given":"Kathryn H.","family":"Hart","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7NX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-2755","authenticated-orcid":false,"given":"Adam E.","family":"Frampton","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery, Royal Surrey Hospital, Guildford GU2 7XX, UK"},{"name":"Oncology Section, Surrey Cancer Research Institute, Department of Clinical and Experimental Medicine, FHMS, University of Surrey, The Leggett Building, Daphne Jackson Road, Guildford GU2 7WG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Denise","family":"Robertson","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7NX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.pan.2015.06.003","article-title":"Pancreatic exocrine insufficiency following pancreatic resection","volume":"15","author":"Phillips","year":"2015","journal-title":"Pancreatol. Off. J. Int. Assoc. Pancreatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jcsm.12274","article-title":"Preoperative sarcopenia and post-operative accelerated muscle loss negatively impact survival after resection of pancreatic cancer","volume":"9","author":"Choi","year":"2018","journal-title":"J. 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