{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:16:28Z","timestamp":1788617788236,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In children, CMV-associated protein-losing enteropathy (PLE) is characterised by a benign course and spontaneous healing but can lead to generalised oedema. Poorly defined, it is diagnosed after unnecessary invasive tests. Children with CMV-associated PLE between 2009 and 2019 in two French hospitals are retrospectively described. Clinical and biological signs, CMV identification, endoscopy and histological findings, disease management and course are analysed. CMV-associated PLE is proven in 21 immunocompetent and 22 immunosuppressed patients, with ages consistent with primo-infection and reactivation, respectively. The digestive symptoms prevail in immunocompetent children, mainly with vomiting (85.7% versus 50%, CI [1.2; 39.2], p = 0.02). Immunocompetent patients show more oedema (61.9% versus 4.5%, CI [3.6; 1502.4], p &lt; 0.001), linked to more severe hypoalbuminemia (21.2 g\/L [17.6\u201325.7] versus 29.6 g\/L [24.9\u201333.9], p = 0.01). A severe course is observed in 23.8% of the immunocompetent patients and 54.5% of the immunosuppressed ones (p = 0.06). Evidence of CMV infection based on non-invasive methods is found on 88.9% of immunocompetent and 95.5% of immunosuppressed patients (p = 0.58), while endoscopy was performed on 95.2% and 100% of them, respectively (p = 0.48), without any therapeutic change. Thus, CMV-associated PLE should be suspected in children with generalised oedema. Not as benign as previously described, it can be confirmed using non-invasive tests.<\/jats:p>","DOI":"10.3390\/nu15132844","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T02:34:07Z","timestamp":1687487647000},"page":"2844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Manifestation of Cytomegalovirus-Associated Protein-Losing Enteropathy in Children"],"prefix":"10.3390","volume":"15","author":[{"given":"Claire","family":"Ferrua","sequence":"first","affiliation":[{"name":"Paediatric Emergency Department, AP-HP, Robert Debr\u00e9 Hospital, Universit\u00e9 Paris Cit\u00e9, 48 Boulevard S\u00e9rurier, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-7207","authenticated-orcid":false,"given":"Anais","family":"Lemoine","sequence":"additional","affiliation":[{"name":"Paediatric Nutrition and Gastroenterology Department, AP-HP, Trousseau Hospital, Sorbonne Universit\u00e9, 26 Avenue du Dr Arnold Netter, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Mosca","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Department, AP-HP, Robert Debr\u00e9 Hospital, Universit\u00e9 Paris Cit\u00e9, 48 Boulevard S\u00e9rurier, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Aur\u00e9lie","family":"Lopes","sequence":"additional","affiliation":[{"name":"Paediatric Emergency Department, AP-HP, Robert Debr\u00e9 Hospital, Universit\u00e9 Paris Cit\u00e9, 48 Boulevard S\u00e9rurier, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/rmv.655","article-title":"Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection","volume":"20","author":"Cannon","year":"2010","journal-title":"Rev. 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