{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:51:21Z","timestamp":1784357481740,"version":"3.55.0"},"reference-count":22,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SBI Pharmaceuticals Co., Ltd."},{"name":"EviPRO Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Sarcopenia is a geriatric syndrome characterized by decreased physical performance, muscle mass, and strength. Since the intake of 5-aminolevulinic acid (ALA) with iron can increase muscle mass and mitochondria in mice and elevate physical exercise performance in humans, the beneficial effects of ALA in patients with sarcopenia are expected, but this remains unexplored in the literature. This study aimed to assess the efficacy and dose dependency of ALA combined with iron in sarcopenia by measuring skeletal muscle mass index (SMI). Subjects with sarcopenia were enrolled and randomized into the ALA and sodium ferrous citrate (SFC) intake groups (ALA50\/SFC29, ALA100\/SFC29, ALA150\/SFC29, ALA 100\/SFC57, and ALA0\/SFC29 placebo) and ingested the assigned study food for 12 weeks. The primary endpoint, the change in SMI from baseline to week 12, did not differ significantly between the groups. Hand grip significantly increased or tended to increase from baseline after 12 weeks with all doses of ALA or SFC compared with the placebo group. No consistent changes were observed in the other endpoints, including calf circumference, physical function, or quality of life (QOL). Although this study suggests safe administration and the possibility of ALA improving hand grip strength in patients with sarcopenia, further investigation is required.<\/jats:p>","DOI":"10.3390\/nu15132866","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T03:14:56Z","timestamp":1687749296000},"page":"2866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and Safety of 5-Aminolevulinic Acid Combined with Iron on Skeletal Muscle Mass Index and Physical Performance of Patients with Sarcopenia: A Multicenter, Double-Blinded, Randomized-Controlled Trial (ALADDIN Study)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7821","authenticated-orcid":false,"given":"Yoshifumi","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"},{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Department of Metabolism and Endocrinology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"},{"name":"Faculty of International Liberal Arts, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-2177","authenticated-orcid":false,"given":"Hideyoshi","family":"Kaga","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yokufukai Hospital, Social Welfare Foundation, Tokyo 168-0071, Japan"},{"name":"Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Department of Medicine, Diabetology and Endocrinology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo 136-0075, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Seino","sequence":"additional","affiliation":[{"name":"Seino Internal Medical Clinic, Fukushima 963-8851, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Hiyoshi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Japanese Red Cross Medical Center, Tokyo 150-893, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuichi","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Misaki Naika Clinic, Chiba 274-0805, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Preventive Medicine Research Center, Saitama Medical University Hospital, Saitama 350-0495, Japan"},{"name":"Department of Endocrinology and Diabetology, Saitama Medical University School of Medicine, Saitama 350-0495, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Watada","sequence":"additional","affiliation":[{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Department of Metabolism and Endocrinology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/ajcn\/50.5.1231","article-title":"Summary comment (in a section: Epidemiologic and methodologic problems in determining nutritional status of older persons)","volume":"50","author":"Rosenberg","year":"1989","journal-title":"Am. 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