{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:57Z","timestamp":1787029197658,"version":"build-2736575974"},"reference-count":118,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER\/Junta de Andaluc\u00eda-Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades","award":["B-AGR-658"],"award-info":[{"award-number":["B-AGR-658"]}]},{"name":"FEDER\/Junta de Andaluc\u00eda-Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades","award":["P21_00101"],"award-info":[{"award-number":["P21_00101"]}]},{"name":"FEDER\/Junta de Andaluc\u00eda-Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades","award":["2021SGR00990"],"award-info":[{"award-number":["2021SGR00990"]}]},{"name":"Excelencia","award":["B-AGR-658"],"award-info":[{"award-number":["B-AGR-658"]}]},{"name":"Excelencia","award":["P21_00101"],"award-info":[{"award-number":["P21_00101"]}]},{"name":"Excelencia","award":["2021SGR00990"],"award-info":[{"award-number":["2021SGR00990"]}]},{"name":"Association of Celiacs and Sensitive to Gluten of the Community of Madrid","award":["B-AGR-658"],"award-info":[{"award-number":["B-AGR-658"]}]},{"name":"Association of Celiacs and Sensitive to Gluten of the Community of Madrid","award":["P21_00101"],"award-info":[{"award-number":["P21_00101"]}]},{"name":"Association of Celiacs and Sensitive to Gluten of the Community of Madrid","award":["2021SGR00990"],"award-info":[{"award-number":["2021SGR00990"]}]},{"name":"Government of Catalonia: Agency for the Management of University and Resarch Grants","award":["B-AGR-658"],"award-info":[{"award-number":["B-AGR-658"]}]},{"name":"Government of Catalonia: Agency for the Management of University and Resarch Grants","award":["P21_00101"],"award-info":[{"award-number":["P21_00101"]}]},{"name":"Government of Catalonia: Agency for the Management of University and Resarch Grants","award":["2021SGR00990"],"award-info":[{"award-number":["2021SGR00990"]}]},{"name":"Nutrici\u00f3n y Ciencias de los Alimentos","award":["B-AGR-658"],"award-info":[{"award-number":["B-AGR-658"]}]},{"name":"Nutrici\u00f3n y Ciencias de los Alimentos","award":["P21_00101"],"award-info":[{"award-number":["P21_00101"]}]},{"name":"Nutrici\u00f3n y Ciencias de los Alimentos","award":["2021SGR00990"],"award-info":[{"award-number":["2021SGR00990"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD\u2019s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression. By analyzing metabolites, we can gain insights into the reasons behind CD\u2019s occurrence, as well as better comprehend the impact of treatment initiation on patients. In this review, we present a collection of articles that showcase the latest breakthroughs in the field of metabolomics in pediatric CD, with the aim of trying to identify CD biomarkers for both early diagnosis and treatment monitoring. These advancements shed light on the potential of metabolomic analysis in enhancing our understanding of the disease and improving diagnostic and therapeutic strategies. More studies need to be designed to cover metabolic profiles in subjects at risk of developing the disease, as well as those analyzing biomarkers for follow-up treatment with a GFD.<\/jats:p>","DOI":"10.3390\/nu15132871","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T03:14:56Z","timestamp":1687749296000},"page":"2871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-9904","authenticated-orcid":false,"given":"Rafael","family":"Mart\u00edn-Masot","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 M\u00e1laga, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 MataixVerd\u00fa\u201d (INYTA), Biomedical Research Centre (CIBM), University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Jim\u00e9nez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-4900","authenticated-orcid":false,"given":"Marta","family":"Herrador-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-252X","authenticated-orcid":false,"given":"V\u00edctor Manuel","family":"Navas-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-1634","authenticated-orcid":false,"given":"Elia","family":"Obis","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-6162","authenticated-orcid":false,"given":"Mariona","family":"Jov\u00e9","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-6107","authenticated-orcid":false,"given":"Reinald","family":"Pamplona","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-3244","authenticated-orcid":false,"given":"Teresa","family":"Nestares","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 MataixVerd\u00fa\u201d (INYTA), Biomedical Research Centre (CIBM), University of Granada, 18071 Granada, Spain"},{"name":"Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Masot, R., Diaz-Castro, J., Moreno-Fernandez, J., Navas-L\u00f3pez, V.M., and Nestares, T. 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