{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:31:31Z","timestamp":1775608291538,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BUMCA intramural fund","award":["07062017"],"award-info":[{"award-number":["07062017"]}]},{"name":"BUMCA intramural fund","award":["01082019"],"award-info":[{"award-number":["01082019"]}]},{"name":"Materna Institute for Research and Infant Nutrition Promotion","award":["07062017"],"award-info":[{"award-number":["07062017"]}]},{"name":"Materna Institute for Research and Infant Nutrition Promotion","award":["01082019"],"award-info":[{"award-number":["01082019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It is unclear how maternal glycemic status and maternal iodine status influence birth weight among individuals with mild-to-moderate iodine deficiency (ID). We studied the association between birth weight and both maternal glucose levels and iodine intake among pregnant women with mild-to-moderate ID. Glucose values were assessed using a glucose challenge test (GCT) and non-fasting glucose levels that were determined before delivery; individuals\u2019 iodine statuses were assessed using an iodine food frequency questionnaire; and serum thyroglobulin (Tg) and urinary iodine concentrations (UIC) were used to assess each group\u2019s iodine status. Thyroid antibodies and free thyroxine (FT4) levels were measured. Obstetric and anthropometric data were also collected. Large-for-gestational age (LGA) status was predicted using a Cox proportional hazards model with multiple confounders. Tg &gt; 13 g\/L was independently associated with LGA (adjusted hazard ratio = 3.4, 95% CI: 1.4\u201310.2, p = 0.001). Estimated iodine intake correlated with FT4 among participants who reported consuming iodine-containing supplements (ICS) after adjusting for confounders (\u03b2 = 0.4, 95% CI: 0.0002\u20130.0008, p = 0.001). Newborn weight percentiles were inversely correlated with maternal FT4 values (\u03b2 = \u22120.2 95% CI:\u22120.08\u2013\u221256.49, p = 0.049). We conclude that in mild-to-moderate ID regions, insufficient maternal iodine status may increase LGA risk. Iodine status and ICS intake may modify the effect that maternal dysglycemia has on offspring weight.<\/jats:p>","DOI":"10.3390\/nu15132914","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:33:07Z","timestamp":1687912387000},"page":"2914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Iodine Intake Modify the Effect of Maternal Dysglycemia on Birth Weight in Mild-to-Moderate Iodine-Deficient Populations? A Mother\u2013Newborn Prospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-1515","authenticated-orcid":false,"given":"Yaniv S.","family":"Ovadia","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel"},{"name":"Foreign Studies Department, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dov","family":"Gefel","sequence":"additional","affiliation":[{"name":"School of Nutritional Science, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoel","family":"Toledano","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Division of Maternal Fetal Medicine, Helen Schneider Women\u2019s Hospital, Rabin Medical Center, Petah Tikva 4941492, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-877X","authenticated-orcid":false,"given":"Shani R.","family":"Rosen","sequence":"additional","affiliation":[{"name":"School of Nutritional Science, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100001, Israel"},{"name":"Center for Healthcare Technology and Innovation Policy Research, Gertner Institute of Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Avrahami-Benyounes","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Center, Maccabi Healthcare Services, Southern Region, Beersheba 8489312, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Groisman","sequence":"additional","affiliation":[{"name":"National Public Health Laboratory, Ministry of Health, Tel Aviv 6108401, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Rorman","sequence":"additional","affiliation":[{"name":"National Public Health Laboratory, Ministry of Health, Tel Aviv 6108401, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihi","family":"Hen","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo","family":"Fytlovich","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry, Barzilai University Medical Center, Ashkelon 7830604, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-0767","authenticated-orcid":false,"given":"Liora S.","family":"Katz","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal Y.","family":"Anteby","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel"},{"name":"Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Shenhav","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel"},{"name":"Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1192\/bjp.179.5.450","article-title":"Birth weight and the risk of depressive disorder in late life","volume":"179","author":"Thompson","year":"2001","journal-title":"Br. 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