{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:57Z","timestamp":1787029197964,"version":"build-2736575974"},"reference-count":43,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["RS-2023-00208567"],"award-info":[{"award-number":["RS-2023-00208567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gastric cancer is one of the most prevalent cancers in Asia, and has a significant global incidence. However, the impact of fried food consumption on gastric cancer risk remains uncertain, mainly due to the limited number of participants in previous studies. To address this knowledge gap, we aimed to examine the association between fried food intake and gastric cancer incidence through a comprehensive meta-analysis. We conducted a thorough search across multiple databases, including PubMed, EMBASE, Google Scholar, Cochrane Library, China National Knowledge Infrastructure (CNKI), Korean Information Service System (KISS), and Research Information Service System (RISS), to collect studies. The newly analyzed results of the Korean Genome and Epidemiology Study (KoGES) findings were added. We assessed integrated odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) from the selected studies using Cochrane RevMan 5.0 for the meta-analysis. The quality of the studies included in the meta-analysis was assessed using the Study Quality Assessment Tool of the National Heart, Lung, and Blood Institute (NHLBI). We included 18 studies in the analysis, which compared the impact of fried food intake in gastric cancer patients (n = 5739) and healthy adults (control, n = 70,933). There was a significant positive association between gastric cancer risk and fried food intake (OR = 1.52, 95% CI = 1.23\u20131.87, I2 = 76%, p = 0.0001). The relationship was found to be significant in both non-East Asians (OR = 1.48, 95% CI = 1.18\u20131.85, I2 = 31%, p = 0.0006) and East Asians (OR = 1.54, 95% CI = 1.14\u20132.08, I2 = 83%, p = 0.005). In conclusion, this meta-analysis supports the notion that fried food intake is associated with an increased risk of gastric cancer in both non-Asians and Asians. Promoting a reduction in fried food consumption as a measure against gastric cancer risk is recommended.<\/jats:p>","DOI":"10.3390\/nu15132982","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:42:46Z","timestamp":1688344966000},"page":"2982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of Fried Food Intake with Gastric Cancer Risk: A Systemic Review and Meta-Analysis of Case\u2013Control Studies"],"prefix":"10.3390","volume":"15","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Bioconvergence, Hoseo University, Asan 31499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Shin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Obesity\/Diabetes Research Center, Hoseo University, Asan 31499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Shanxi Institute of Science and Technology, Jincheng 048011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6092-8340","authenticated-orcid":false,"given":"Sunmin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bioconvergence, Hoseo University, Asan 31499, Republic of Korea"},{"name":"Department of Food and Nutrition, Obesity\/Diabetes Research Center, Hoseo University, Asan 31499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5230\/jgc.2023.23.e11","article-title":"Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach","volume":"23","author":"Kim","year":"2023","journal-title":"J. Gastric Cancer"},{"key":"ref_3","unstructured":"World Cancer Research Fund International, and American Institute for Cancer Research (2018). Diet, Nutrition, Physical Activity and Cancer: A Global Perspective: A Summary of the Third Expert Report, World Cancer Research Fund International."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1017\/S0007114514002347","article-title":"Possible adverse effects of frying with vegetable oils","volume":"113","author":"Dobarganes","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/hed.10142","article-title":"Nutrition and pharyngeal cancer: Results from a case-control study in Spain","volume":"24","author":"Uzcudun","year":"2002","journal-title":"Head Neck"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/sj.bjc.6600639","article-title":"Fried foods: A risk factor for laryngeal cancer?","volume":"87","author":"Bosetti","year":"2002","journal-title":"Br. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/ijc.27777","article-title":"Risk factors for gallbladder cancer: A case-control study","volume":"132","author":"Jain","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_8","first-page":"707","article-title":"Environmental and psycho-social factors related to prostate cancer risk in the Chinese population: A case-control study","volume":"27","author":"Li","year":"2014","journal-title":"Biomed. Environ. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"889303","DOI":"10.3389\/fnut.2022.889303","article-title":"Fried food consumption and the risk of pancreatic cancer: A large prospective multicenter study","volume":"9","author":"Zhong","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_10","first-page":"7","article-title":"Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: What are they and which is better?","volume":"7","author":"Ma","year":"2020","journal-title":"Mil. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/ije\/24.1.33","article-title":"Dietary factors and stomach cancer: A case-control study in Korea","volume":"24","author":"Lee","year":"1995","journal-title":"Int. J. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.3748\/wjg.v12.i36.5772","article-title":"Risk factors of gastric cancer-specific for tumor location and histology in Cali, Colombia","volume":"12","author":"Campos","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1136\/gutjnl-2018-317556","article-title":"Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: A nationwide multicentre study","volume":"68","author":"Cai","year":"2019","journal-title":"Gut"},{"key":"ref_14","first-page":"488","article-title":"Effects of environmental carcinogens and genetic polymorphisms of CYP2E1 and NAT2 on gastric carcinogenesis","volume":"59","author":"Park","year":"2000","journal-title":"J. Korean Surg. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.7314\/APJCP.2013.14.5.2897","article-title":"A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou","volume":"14","author":"Sun","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1016\/j.canep.2012.02.003","article-title":"Polymorphisms in MSH2 gene and risk of gastric cancer, and interactions with lifestyle factors in a Chinese population","volume":"36","author":"Wang","year":"2012","journal-title":"Cancer Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/1097-0142(19900515)65:10<2344::AID-CNCR2820651030>3.0.CO;2-H","article-title":"Diet and stomach cancer incidence. A case-control study in Turkey","volume":"65","author":"Demirer","year":"1990","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00008469-199206000-00004","article-title":"Dietary practices in households as risk factors for stomach cancer: A familial study in Poland","volume":"1","author":"Jedrychowski","year":"1992","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<659::AID-IJC8>3.0.CO;2-P","article-title":"Dietary habits and stomach cancer in Shanghai, China","volume":"76","author":"Ji","year":"1998","journal-title":"Int. J. Cancer"},{"key":"ref_20","first-page":"16","article-title":"Study on the relationship between dietary factors and gastric cancer","volume":"13","author":"Sun","year":"1999","journal-title":"J. Practical Oncol."},{"key":"ref_21","first-page":"170","article-title":"Multivariate analysis of the association between consumption of fried food and gastric cancer and precancerous lesions","volume":"52","author":"Guo","year":"2018","journal-title":"Chin. J. Prev. Med."},{"key":"ref_22","first-page":"1453","article-title":"A case- control study on the relationship between diet habit and gastric cancer in Xian, China","volume":"20","author":"Jiang","year":"2012","journal-title":"Modern Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1207\/S15327914NC402_5","article-title":"Meat consumption and risk of stomach cancer in Uruguay: A case-control study","volume":"40","author":"Ronco","year":"2001","journal-title":"Nutr. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.7150\/jca.39023","article-title":"Preventable lifestyle and eating habits associated with gastric adenocarcinoma: A case-control study","volume":"11","author":"Huang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Li, L., Ni, J., Sun, S., Zha, X., Li, R., and He, C. (2022). Clinical applicability of a new scoring system for population-based screening and risk factors of gastric cancer in the Wannan region. BMC Gastroenterol., 22.","DOI":"10.1186\/s12876-022-02384-w"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10552-011-9744-5","article-title":"Dietary habits and gastric cancer risk in north-west Iran","volume":"22","author":"Pakseresht","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.7314\/APJCP.2015.16.1.283","article-title":"Is there any relationship between food habits in the last two decades and gastric cancer in North-Western Iran?","volume":"16","author":"Somi","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_28","unstructured":"Song, S.S. (2023). Genetic Factors, Dietary Intake, and the Risk of Gastric Cancer: Genetic Interaction between Polygenetic Risk Scores for Gastric Cancer and Dietary Intake, Hoseo University."},{"key":"ref_29","unstructured":"Cochrane committee (2023, June 27). Cochrane Review Manager (RevMan) 5.3. Available online: https:\/\/training.cochrane.org\/online-learning\/core-software\/revman."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1467-985X.2008.00552.x","article-title":"A re-evaluation of random-effects meta-analysis","volume":"172","author":"Higgins","year":"2009","journal-title":"J. R. Stat. Soc. Ser. A Stat. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/2046-4053-3-37","article-title":"Evaluation of the Cochrane Collaboration\u2019s tool for assessing the risk of bias in randomized trials: Focus groups, online survey, proposed recommendations and their implementation","volume":"3","author":"Weeks","year":"2014","journal-title":"Syst. Rev."},{"key":"ref_32","first-page":"675","article-title":"Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps","volume":"3","author":"Lang","year":"1994","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_33","first-page":"4320","article-title":"Well-done, grilled red meat increases the risk of colorectal adenomas","volume":"59","author":"Sinha","year":"1999","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Salehzadeh, H., Maleki, A., Rezaee, R., Shahmoradi, B., and Ponnet, K. (2020). The nitrate content of fresh and cooked vegetables and their health-related risks. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227551"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.foodchem.2007.06.005","article-title":"Nitrate-N determination in leafy vegetables: Study of the effects of cooking and freezing","volume":"106","author":"Prasad","year":"2008","journal-title":"Food Chem."},{"key":"ref_36","first-page":"135","article-title":"Food consumption and digestive cancers in the province of batna","volume":"19","author":"Mihoubi","year":"2018","journal-title":"Ann. Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0140-6736(98)06099-1","article-title":"Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney: A population-based study","volume":"353","author":"Augustsson","year":"1999","journal-title":"Lancet"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.3945\/jn.108.092957","article-title":"Dietary acrylamide intake is not associated with gastrointestinal cancer risk","volume":"138","author":"Hogervorst","year":"2008","journal-title":"J. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ijc.11118","article-title":"Fried potatoes and human cancer","volume":"105","author":"Pelucchi","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_40","first-page":"137","article-title":"A case-control study on the risk factors of Helicobacter pylori infection in Korea","volume":"36","author":"Chang","year":"2000","journal-title":"J. Prev. Med. Public. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10486","DOI":"10.3748\/wjg.v20.i30.10486","article-title":"Clinical epidemiology of gastric cancer in Hehuang valley of China: A 10-year epidemiological study of gastric cancer","volume":"20","author":"Yan","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"714970","DOI":"10.5402\/2013\/714970","article-title":"Irregular Meal Timing Is Associated with Helicobacter pylori Infection and Gastritis","volume":"2013","author":"Lim","year":"2013","journal-title":"ISRN Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21451","DOI":"10.18632\/aging.203484","article-title":"Identification and epidemiological evaluation of gastric cancer risk factors: Based on a field synopsis and meta-analysis in Chinese population","volume":"13","author":"Duan","year":"2021","journal-title":"Aging"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/13\/2982\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:03:45Z","timestamp":1760126625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/13\/2982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":43,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["nu15132982"],"URL":"https:\/\/doi.org\/10.3390\/nu15132982","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}