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However, there is little evidence demonstrating its influence on vascular regeneration. Therefore, we evaluated the modulation of carvacrol on endothelial repair induced by endothelial progenitor cells (EPC) in hypertension. Twelve-week-old spontaneously hypertensive rats (SHR) were treated with a vehicle, carvacrol (50 or 100 mg\/kg\/day), or resveratrol (10 mg\/kg\/day) orally for four weeks. Wistar Kyoto (WKY) rats were used as the normotensive controls. Their systolic blood pressure (SBP) was measured weekly through the tail cuff. The EPCs were isolated from the bone marrow and peripherical circulation and were quantified by flow cytometry. The functionality of the EPC was evaluated after cultivation through the quantification of colony-forming units (CFU), evaluation of eNOS, intracellular detection of reactive oxygen species (ROS), and evaluation of senescence. The superior mesenteric artery was isolated to evaluate the quantification of ROS, CD34, and CD31. Treatment with carvacrol induced EPC migration, increased CFU formation and eNOS expression and activity, and reduced ROS and senescence. In addition, carvacrol reduced vascular ROS and increased CD31 and CD34 expression. This study showed that treatment with carvacrol improved the functionality of EPC, contributing to the reduction of endothelial dysfunction.<\/jats:p>","DOI":"10.3390\/nu15133032","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:37:28Z","timestamp":1688517448000},"page":"3032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Carvacrol Improves Vascular Function in Hypertensive Animals by Modulating Endothelial Progenitor Cells"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-132X","authenticated-orcid":false,"given":"Tays Amanda Felisberto","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Silva","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-3249","authenticated-orcid":false,"given":"Arthur Jos\u00e9 Pontes Oliveira","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alinne Villar","family":"de Arruda","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Caroline Meneses Ferreira","family":"Veras","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Trajano","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evyllen Myllena Cardoso","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhonias Correia dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda Costa de","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathania Silva","family":"de Almeida Feitosa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Cavalcante","family":"Veras","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isac Almeida","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58059-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yan, F., Liu, X., Ding, H., and Zhang, W. 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