{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:53:35Z","timestamp":1792497215356,"version":"4.5.0"},"reference-count":89,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa Operativo de Empleo Juvenil (Youth Employment Program)","award":["P21_00777"],"award-info":[{"award-number":["P21_00777"]}]},{"name":"Junta de Andaluc\u00eda-Consejer\u00eda de Universidad, Investigaci\u00f3n e Innovaci\u00f3n Research Project","award":["P21_00777"],"award-info":[{"award-number":["P21_00777"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Honey is a nutritious, healthy, and natural food, to which antioxidant, anti-inflammatory, and antimicrobial properties have been attributed, mainly due to its content of phenolic compounds. The aim of this review is to analyze the available evidence of the effect of honey on humans. Forty-eight clinical trials published between 1985 and 2022 were analyzed, with a total of 3655 subjects. More beneficial effects of honey intake than no or negative effects on different cardiovascular and metabolic risk factors, glucose tolerance, mucositis caused by chemo-radiotherapy, cough in children and wound healing, among others have been observed. Although the number of studies conducted to date is limited and the different investigations are not standardized, beneficial effects of honey intake have been observed, especially when its intake replaces the intake of other sweeteners. In addition, honey could be a safe adjuvant to be administered alongside drugs used for certain diseases.<\/jats:p>","DOI":"10.3390\/nu15133056","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T02:28:46Z","timestamp":1688696926000},"page":"3056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["A Comprehensive Review of the Effect of Honey on Human Health"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-9218","authenticated-orcid":false,"given":"Marta","family":"Palma-Morales","sequence":"first","affiliation":[{"name":"Biomedical Research Centre, Institute of Nutrition and Food Technology (INYTA) \u2018Jos\u00e9 Mataix\u2019, University of Granada, Avda. del Conocimiento s\/n, 18071 Granada, Spain"},{"name":"Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, Cartuja Campus, 18011 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-0857","authenticated-orcid":false,"given":"Jes\u00fas","family":"Huertas","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, Institute of Nutrition and Food Technology (INYTA) \u2018Jos\u00e9 Mataix\u2019, University of Granada, Avda. del Conocimiento s\/n, 18071 Granada, Spain"},{"name":"Primary Care Promotion of Maternal, Child and Women\u2019s Health for Prevention of Adult Chronic Diseases Network (RD21\/0012\/0008), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-6481","authenticated-orcid":false,"given":"Celia","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, Institute of Nutrition and Food Technology (INYTA) \u2018Jos\u00e9 Mataix\u2019, University of Granada, Avda. del Conocimiento s\/n, 18071 Granada, Spain"},{"name":"Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, Cartuja Campus, 18011 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Becerril-S\u00e1nchez, A.L., Quintero-Salazar, B., Dubl\u00e1n-Garc\u00eda, O., and Escalona-Buend\u00eda, H.B. (2021). Phenolic Compounds in Honey and Their Relationship with Antioxidant Activity, Botanical Origin, and Color. Antioxidants, 10.","DOI":"10.3390\/antiox10111700"},{"key":"ref_2","unstructured":"Insights, F.B. (2022, December 09). Market Value of Honey Worldwide from 2019 to 2028 (in Billion U.S. Dollars). Available online: https:\/\/www.statista.com\/statistics\/933928\/global-market-value-of-honey\/."},{"key":"ref_3","unstructured":"Jha, A. (2022, December 07). Natural Honey: At the Tip of the Beehive. Available online: https:\/\/www.tpci.in\/indiabusinesstrade\/blogs\/natural-honey-at-the-tip-of-the-beehive\/."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ciulu, M., Spano, N., Pilo, M.I., and Sanna, G. (2016). Recent Advances in the Analysis of Phenolic Compounds in Unifloral Honeys. Molecules, 21.","DOI":"10.3390\/molecules21040451"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/00218839.2020.1714193","article-title":"Sugar profile of different floral origin honeys from Serbia","volume":"59","author":"Popov","year":"2020","journal-title":"J. Apic. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00217-018-3034-3","article-title":"Chromatographic fingerprint, antioxidant activity, and colour characteristic of polish goldenrod (Solidago virgaurea L.) honey and flower","volume":"244","author":"Makowicz","year":"2018","journal-title":"Eur. Food Res. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cianciosi, D., Forbes-Hern\u00e1ndez, T.Y., Afrin, S., Gasparrini, M., Reboredo-Rodriguez, P., Manna, P.P., Zhang, J., Bravo Lamas, L., Mart\u00ednez Fl\u00f3rez, S., and Agudo Toyos, P. (2018). Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules, 23.","DOI":"10.3390\/molecules23092322"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5897\/AJAR2016.11677","article-title":"Plant secondary metabolites and its dynamical systems of induction in response to environmental factors: A review","volume":"12","author":"Olivoto","year":"2017","journal-title":"Afr. J. Agric. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s11694-018-9810-8","article-title":"Evaluation of antioxidant and antibacterial activities of the stems of Flammulina velutipes and Hypsizygus tessellatus (white and brown var.) extracted with different solvents","volume":"12","author":"Shah","year":"2018","journal-title":"J. Food Meas. Charact."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11130-010-0205-1","article-title":"Phenolic Compounds as Cultivar- and Variety-distinguishing Factors in Some Plant Products","volume":"66","author":"Klepacka","year":"2011","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zawawi, N., Chong, P.J., Mohd Tom, N.N., Saiful Anuar, N.S., Mohammad, S.M., Ismail, N., and Jusoh, A.Z. (2021). Establishing Relationship between Vitamins, Total Phenolic and Total Flavonoid Content and Antioxidant Activities in Various Honey Types. Molecules, 26.","DOI":"10.3390\/molecules26154399"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clnesp.2018.04.016","article-title":"The effect of honey consumption compared with sucrose on lipid profile in young healthy subjects (randomized clinical trial)","volume":"26","author":"Rasad","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_13","first-page":"42","article-title":"Effects of natural honey on blood glucose and lipid profile in young healthy Pakistani males","volume":"25","author":"Majid","year":"2013","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nutres.2019.11.012","article-title":"Honey does not adversely impact blood lipids of adult men and women: A randomized cross-over trial","volume":"74","author":"Petrisko","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1100\/tsw.2008.64","article-title":"Natural Honey and Cardiovascular Risk Factors; Effects on Blood Glucose, Cholesterol, Triacylglycerole, CRP, and Body Weight Compared with Sucrose","volume":"8","author":"Yaghoobi","year":"2008","journal-title":"Sci. World J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13042","DOI":"10.1111\/eci.13042","article-title":"Effect of honey on glucose and insulin concentrations in obese girls","volume":"49","author":"Farakla","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3945\/jn.115.218016","article-title":"Consumption of Honey, Sucrose, and High-Fructose Corn Syrup Produces Similar Metabolic Effects in Glucose-Tolerant and -Intolerant Individuals","volume":"145","author":"Raatz","year":"2015","journal-title":"J. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ctim.2018.08.015","article-title":"Long-term effects of honey on cardiovascular parameters and anthropometric measurements of postmenopausal women","volume":"41","author":"Zakaria","year":"2018","journal-title":"Complement. Ther. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3109\/09637480801990389","article-title":"Effects of natural honey consumption in diabetic patients: An 8-week randomized clinical trial","volume":"60","author":"Bahrami","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1089\/jmf.2012.0108","article-title":"Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A Randomized Crossover Pilot Study","volume":"16","author":"Abdulrhman","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1089\/109662004322984789","article-title":"Natural Honey Lowers Plasma Glucose, C-Reactive Protein, Homocysteine, and Blood Lipids in Healthy, Diabetic, and Hyperlipidemic Subjects: Comparison with Dextrose and Sucrose","volume":"7","author":"Whitfield","year":"2004","journal-title":"J. Med. Food"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1089\/jmf.2008.0188","article-title":"Effect of Honey on Serum Cholesterol and Lipid Values","volume":"12","author":"Hoffmann","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/jmf.2007.0608","article-title":"Effects of Basswood Honey, Honey-Comparable Glucose-Fructose Solution, and Oral Glucose Tolerance Test Solution on Serum Insulin, Glucose, and C-Peptide Concentrations in Healthy Subjects","volume":"11","author":"Sheybani","year":"2008","journal-title":"J. Med. Food"},{"key":"ref_24","first-page":"69","article-title":"Comparison of glycaemic response to honey and glucose in type 2 diabetes","volume":"64","author":"Nazir","year":"2014","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ctcp.2012.08.002","article-title":"Effects of honey, sucrose and glucose on blood glucose and C-peptide in patients with type 1 diabetes mellitus","volume":"19","author":"Abdulrhman","year":"2013","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/07315724.2010.10719885","article-title":"Effect of Honey versus Sucrose on Appetite, Appetite-Regulating Hormones, and Postmeal Thermogenesis","volume":"29","author":"Willis","year":"2010","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_27","first-page":"984","article-title":"Effect of Nigerian citrus (Citrus sinensis Osbeck) honey on ethanol metabolism: Original article","volume":"94","author":"Onyesom","year":"2004","journal-title":"South Afr. Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000087336","article-title":"Honey-Induced Stimulation of Blood Ethanol Elimination and Its Influence on Serum Triacylglycerol and Blood Pressure in Man","volume":"49","author":"Onyesom","year":"2005","journal-title":"Ann. Nutr. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00784-018-2621-9","article-title":"The effect of an oral care protocol and honey mouthwash on mucositis in acute myeloid leukemia patients undergoing chemotherapy: A single-blind clinical trial","volume":"23","author":"Rahmani","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejon.2018.04.003","article-title":"The effect of the use of thyme honey in minimizing radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled trial","volume":"34","author":"Charalambous","year":"2018","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.ijom.2010.05.014","article-title":"Effect of topical honey on limitation of radiation-induced oral mucositis: An intervention study","volume":"39","author":"Khanal","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0022215108002478","article-title":"Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer","volume":"123","author":"Rashad","year":"2009","journal-title":"J. Laryngol. Otol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5005\/jcdp-9-3-40","article-title":"The Effect of Topical Application of Pure Honey on Radiation-induced Mucositis: A Randomized Clinical Trial","volume":"9","author":"Motallebnejad","year":"2008","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00520-003-0443-y","article-title":"Topical application of honey in the management of radiation mucositis. A Preliminary study","volume":"11","author":"Biswal","year":"2003","journal-title":"Support. Care Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejon.2017.01.001","article-title":"The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial","volume":"27","author":"Charalambous","year":"2017","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00520-013-2031-0","article-title":"A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis","volume":"22","author":"Hawley","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bjoms.2011.03.005","article-title":"A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis","volume":"50","author":"Bardy","year":"2012","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/08880018.2012.669026","article-title":"Honey and a Mixture of Honey, Beeswax, and Olive Oil\u2013Propolis Extract in Treatment of Chemotherapy-Induced Oral Mucositis: A Randomized Controlled Pilot Study","volume":"29","author":"Abdulrhman","year":"2012","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1016\/j.pedn.2019.02.001","article-title":"The Effect of Oral Care with Chlorhexidine, Vitamin E and Honey on Mucositis in Pediatric Intensive Care Patients: A Randomized Controlled Trial","volume":"45","author":"Sener","year":"2019","journal-title":"J. Pediatr. Nurs."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1385\/MO:23:4:549","article-title":"Prevention of Chemotherapy-Induced Neutropenia by Special Honey Intake","volume":"23","author":"Zidan","year":"2006","journal-title":"Med. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ctim.2016.01.009","article-title":"Effect of honey on febrile neutropenia in children with acute lymphoblastic leukemia: A randomized crossover open-labeled study","volume":"25","author":"Abdulrhman","year":"2016","journal-title":"Complement. Ther. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1001\/archpedi.161.12.1140","article-title":"Effect of Honey, Dextromethorphan, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents","volume":"161","author":"Paul","year":"2007","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1089\/acm.2009.0311","article-title":"A Comparison of the Effect of Honey, Dextromethorphan, and Diphenhydramine on Nightly Cough and Sleep Quality in Children and Their Parents","volume":"16","author":"Shadkam","year":"2010","journal-title":"J. Altern. Complement. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1542\/peds.2011-3075","article-title":"Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study","volume":"130","author":"Cohen","year":"2012","journal-title":"Pediatrics"},{"key":"ref_45","first-page":"50","article-title":"Randomised double blind study to compare effectiveness of honey, salbutamol and placebo in treatment of cough in children with common cold","volume":"91","author":"Waris","year":"2014","journal-title":"East Afr. Med. J."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ayazi, P., Mahyar, A., Yousef-Zanjani, M., Allami, A., Esmailzadehha, N., and Beyhaghi, T. (2017). Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170277"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1111\/apa.16509","article-title":"Multicentre, randomised study found that honey had no pharmacological effect on nocturnal coughs and sleep quality at 1\u20135 years of age","volume":"111","author":"Nishimura","year":"2022","journal-title":"Acta Paediatr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1136\/bmj.290.6485.1866","article-title":"Honey in the treatment of infantile gastroenteritis","volume":"290","author":"Haffejee","year":"1985","journal-title":"Br. Med. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1902\/jop.2012.110461","article-title":"A Comparative Evaluation of the Antibacterial Efficacy of Honey In Vitro and Antiplaque Efficacy in a 4-Day Plaque Regrowth Model In Vivo: Preliminary Results","volume":"83","author":"Aparna","year":"2012","journal-title":"J. Periodontol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.mycmed.2017.07.003","article-title":"Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial","volume":"27","author":"Banaeian","year":"2017","journal-title":"J. Med. Mycol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/acm.2005.11.511","article-title":"Comparison of Healing of Incised Abscess Wounds with Honey and EUSOL Dressing","volume":"11","author":"Okeniyi","year":"2005","journal-title":"J. Altern. Complement. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20160139","DOI":"10.1515\/jcim-2016-0139","article-title":"Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women","volume":"15","author":"Lavaf","year":"2018","journal-title":"J. Complement. Integr. Med."},{"key":"ref_53","first-page":"721","article-title":"A randomized, controlled clinical trial of honey-impregnated dressing for treating diabetic foot ulcer","volume":"25","author":"Imran","year":"2015","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.diabres.2010.05.021","article-title":"The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers","volume":"89","author":"Moghazy","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_55","first-page":"44","article-title":"A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers","volume":"63","author":"Shukrimi","year":"2008","journal-title":"Med. J. Malays."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1021\/jf025928k","article-title":"Honey with High Levels of Antioxidants Can Provide Protection to Healthy Human Subjects","volume":"51","author":"Schramm","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jtos.2019.11.009","article-title":"Randomized masked trial of the clinical efficacy of MGO Manuka Honey microemulsion eye cream for the treatment of blepharitis","volume":"18","author":"Craig","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1081-1206(10)61996-5","article-title":"Effect of ingestion of honey on symptoms of rhinoconjunctivitis","volume":"88","author":"Rajan","year":"2002","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1017\/S0007114509992777","article-title":"Demonstrating the safety of manuka honey UMF\u00ae 20+ in a human clinical trial with healthy individuals","volume":"103","author":"Wallace","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00404-017-4409-6","article-title":"Comparison of the effect of honey and mefenamic acid on the severity of pain in women with primary dysmenorrhea","volume":"296","author":"Kasraei","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1111\/j.1750-3841.2007.00592.x","article-title":"The Long-Term Effects of Feeding Honey Compared with Sucrose and a Sugar-Free Diet on Weight Gain, Lipid Profiles, and DEXA Measurements in Rats","volume":"73","author":"Chepulis","year":"2008","journal-title":"J. Food Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11255-004-0871-8","article-title":"Effects of Honey on the Urinary Total Nitrite and Prostaglandins Concentration","volume":"37","year":"2005","journal-title":"Int. Urol. Nephrol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.2337\/diabetes.51.12.3450","article-title":"Exogenous Nitric Oxide and Endogenous Glucose-Stimulated \u03b2-Cell Nitric Oxide Augment Insulin Release","volume":"51","author":"Smukler","year":"2002","journal-title":"Diabetes"},{"key":"ref_64","first-page":"135","article-title":"Effects of Daily Consumption of Honey Solution on Hematological Indices and Blood Levels of Minerals and Enzymes in Normal Individuals","volume":"6","year":"2004","journal-title":"J. Med. Food"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/BTER:112:2:109","article-title":"Effect of Zinc Supplementation on Serum Leptin Levels and Insulin Resistance of Obese Women","volume":"112","author":"Marreiro","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-7075-2-5","article-title":"Fructose, insulin resistance, and metabolic dyslipidemia","volume":"2","author":"Basciano","year":"2005","journal-title":"Nutr. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"553","DOI":"10.18388\/abp.2010_2443","article-title":"Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: An in vivo study in rats","volume":"57","author":"Najafian","year":"2010","journal-title":"Acta Biochim. Pol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/jmf.2006.293","article-title":"A Study of Antidiabetic and Antioxidant Effects of Helichrysum graveolens Capitulums in Streptozotocin-Induced Diabetic Rats","volume":"10","author":"Aslan","year":"2007","journal-title":"J. Med. Food"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1248\/bpb.30.1123","article-title":"Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents","volume":"30","author":"Li","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1016\/j.fct.2008.03.020","article-title":"Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats","volume":"46","author":"Sharma","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1271\/bbb.64.2458","article-title":"Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid","volume":"64","author":"Kim","year":"2000","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3177\/jnsv.52.149","article-title":"Inhibition of \u03b1-Glucosidase and \u03b1-Amylase by Flavonoids","volume":"52","author":"Tadera","year":"2006","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1021\/jm800115x","article-title":"Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human \u03b1-Amylase","volume":"51","author":"Scheib","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/nu5020498","article-title":"Fat Depots, Free Fatty Acids, and Dyslipidemia","volume":"5","author":"Ebbert","year":"2013","journal-title":"Nutrients"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1021\/jf0114637","article-title":"Antioxidant Capacity of Honeys from Various Floral Sources Based on the Determination of Oxygen Radical Absorbance Capacity and Inhibition of in Vitro Lipoprotein Oxidation in Human Serum Samples","volume":"50","author":"Gheldof","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00284-008-9202-0","article-title":"Detection and Identification of a Novel Lactic Acid Bacterial Flora Within the Honey Stomach of the Honeybee Apis mellifera","volume":"57","author":"Olofsson","year":"2008","journal-title":"Curr. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2337\/dc08-1241","article-title":"Fasting Plasma C-Peptide and Micro- and Macrovascular Complications in a Large Clinic-Based Cohort of Type 1 Diabetic Patients","volume":"32","author":"Panero","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0463.2011.02765.x","article-title":"What causes type 1 diabetes? Lessons from animal models","volume":"119","author":"Buschard","year":"2011","journal-title":"Apmis"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1089\/jmf.2006.9.451","article-title":"Green Tea Extract Thermogenesis-Induced Weight Loss by Epigallocatechin Gallate Inhibition of Catechol-O-Methyltransferase","volume":"9","author":"Shixian","year":"2007","journal-title":"J. Med. Food"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/0973-1075.164892","article-title":"A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients","volume":"21","author":"Samdariya","year":"2015","journal-title":"Indian J. Palliat. Care"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5861024","DOI":"10.1155\/2017\/5861024","article-title":"Effects of Honey on Oral Mucositis among Pediatric Cancer Patients Undergoing Chemo\/Radiotherapy Treatment at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia","volume":"2017","author":"Hussein","year":"2017","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_82","first-page":"121","article-title":"Honey and health: A review of recent clinical research","volume":"9","author":"Samarghandian","year":"2017","journal-title":"Pharmacogn. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1017\/S0007114512002073","article-title":"Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy","volume":"109","author":"Green","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/hed.24431","article-title":"Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature","volume":"38","author":"Co","year":"2016","journal-title":"Head Neck"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cytogfr.2014.07.011","article-title":"G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent","volume":"25","author":"Bendall","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.resp.2005.10.004","article-title":"Mechanisms of the placebo effect of sweet cough syrups","volume":"152","author":"Eccles","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/sj.jp.7211651","article-title":"Infant botulism","volume":"27","author":"Brook","year":"2007","journal-title":"J. Perinatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.arcped.2014.03.009","article-title":"Botulisme infantile apr\u00e8s exposition \u00e0 du miel","volume":"21","author":"Godart","year":"2014","journal-title":"Arch. Pediatr."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2010). Scientific Opinion on the substantiation of health claims related to honey and \u201crespiratory health through presence of antioxidant phytochemicals\u201d (ID 1161), \u201cthe unique composition and ratio of effective substances adds energy to the human body\u201d (ID 3188), and \u201cit stimulates the whole metabolism and the immune system\u201d (ID 3189) pursuant to Article 13(1) of Regulation (EC) No 1924\/2006. 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