{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:53:02Z","timestamp":1787662382995,"version":"build-2736575974"},"reference-count":101,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cyprus National Scholarships Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Evidence of the effectiveness of zinc (Zn) and selenium (Se) on resting metabolic rate (RMR) and physical function parameters in people with overweight and obesity is scarce, while the effects of zinc and selenium on thyroid function and body composition are still a topic of debate and controversy. The aim of this randomized, double-blind, and placebo-controlled trial was to examine the effects of a hypocaloric diet and Se\u2013Zn co-supplementation on RMR, thyroid function, body composition, physical fitness, and functional capacity in overweight or obese individuals. Twenty-eight overweight\u2013obese participants (mean BMI: 29.4 \u00b1 4.7) were randomly allocated (1:1) to the supplementation group (n = 14, 31.1 \u00b1 5.5 yrs, 9 females) and the placebo group (n = 14, 32.1 \u00b1 4.8 yrs, 6 females). The participants received Zn (25 mg of zinc gluconate\/day) and Se (200 mcg of L-selenomethionine\/day) or placebo tablets containing starch for eight weeks. The participants of both groups followed a hypocaloric diet during the intervention. RMR, thyroid function, body composition, cardiorespiratory fitness (VO2max), and functional capacity (sit-to-stand tests, timed up-and-go test, and handgrip strength) were assessed before and after the intervention. A significant interaction was found between supplementation and time on RMR (p = 0.045), with the intervention group\u2019s RMR increasing from 1923 \u00b1 440 to 2364 \u00b1 410 kcal\/day. On the other hand, no interaction between supplementation and time on the thyroid function was found (p &gt; 0.05). Regarding the effects of Zn\/Se co-administration on Se levels, a significant interaction between supplementation and time on Se levels was detected (p = 0.004). Specifically, the intervention group\u2019s Se serum levels were increased from 83.04 \u00b1 13.59 to 119.40 \u00b1 23.93 \u03bcg\/L. However, Zn serum levels did not change over time (90.61 \u00b1 23.23 to 89.58 \u00b1 10.61 umol\/L). Even though all body composition outcomes improved in the intervention group more than placebo at the second measurement, no supplement \u00d7 time interaction was detected on body composition (p &gt; 0.05). Cardiorespiratory fitness did not change over the intervention. Yet, a main effect of time was found for some functional capacity tests, with both groups improving similarly over the eight-week intervention period (p &lt; 0.05). In contrast, a supplement x group interaction was found in the performance of the timed up-and-go test (TUG) (p = 0.010), with the supplementation group improving more. In conclusion, an eight-week intervention with Zn\/Se co-supplementation combined with a hypocaloric diet increased the RMR, TUG performance, and Se levels in overweight and obese people. However, thyroid function, Zn levels, body composition, and the remaining outcomes of exercise performance remained unchanged.<\/jats:p>","DOI":"10.3390\/nu15143133","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:39:41Z","timestamp":1689295181000},"page":"3133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Effects of Zinc and Selenium Co-Supplementation on Resting Metabolic Rate, Thyroid Function, Physical Fitness, and Functional Capacity in Overweight and Obese People under a Hypocaloric Diet: A Randomized, Double-Blind, and Placebo-Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"given":"Antonis","family":"Zavros","sequence":"first","affiliation":[{"name":"Department of Life Sciences, University of Nicosia, Nicosia 2417, Cyprus"},{"name":"Research Centre for Exercise and Nutrition (RECEN), Nicosia 2417, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-6782","authenticated-orcid":false,"given":"Eleni","family":"Andreou","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Nicosia, Nicosia 2417, Cyprus"},{"name":"Research Centre for Exercise and Nutrition (RECEN), Nicosia 2417, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-4782","authenticated-orcid":false,"given":"George","family":"Aphamis","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Nicosia, Nicosia 2417, Cyprus"},{"name":"Research Centre for Exercise and Nutrition (RECEN), Nicosia 2417, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-0438","authenticated-orcid":false,"given":"Gregory C.","family":"Bogdanis","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 10679 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2462-995X","authenticated-orcid":false,"given":"Giorgos K.","family":"Sakkas","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Roupa","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Nicosia, Nicosia 2417, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-1189","authenticated-orcid":false,"given":"Christoforos D.","family":"Giannaki","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Nicosia, Nicosia 2417, Cyprus"},{"name":"Research Centre for Exercise and Nutrition (RECEN), Nicosia 2417, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"ref_1","unstructured":"(2021, March 27). 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