{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:20:26Z","timestamp":1760149226646,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agriculture and Agri-Food, Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oats are considered a functional food due to the beneficial health effects associated with their consumption and are suitable to be explored for their ability to prevent or manage chronic disease, such as hypertension. Here, we examined the cardiovascular benefits of an oat beta-glucan extract in male and female spontaneously hypertensive rats (SHRs) to unravel its sex-specific roles when used with an anti-hypertensive medication, hydrochlorothiazide. Five-week-old male and female SHRs and Wistar\u2013Kyoto (WKY) rats were treated with oat beta-glucan and hydrochlorothiazide for 15 weeks. Twenty-week-old male and female SHRs showed high blood pressure (BP), cardiac remodeling, and cardiac dysfunction. These animals also had significantly increased levels of malondialdehyde (MDA), angiotensin II, and norepinephrine. Treatments with beta-glucan and hydrochlorothiazide were able to differentially prevent high BP, cardiac dysfunction, and alterations in malondialdehyde (MDA), angiotensin II, and norepinephrine in 20-week-old male and female SHRs. To conclude, beta-glucan alone and in combination with hydrochlorothiazide may be a promising a strategy for managing hypertension and related cardiac complications.<\/jats:p>","DOI":"10.3390\/nu15143180","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:54:01Z","timestamp":1689728041000},"page":"3180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats"],"prefix":"10.3390","volume":"15","author":[{"given":"Pema","family":"Raj","sequence":"first","affiliation":[{"name":"St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Sayfee","sequence":"additional","affiliation":[{"name":"St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada"},{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Yu","sequence":"additional","affiliation":[{"name":"St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada"},{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada"},{"name":"Agriculture and Agri-Food Canada, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Sabra","sequence":"additional","affiliation":[{"name":"St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada"},{"name":"Agriculture and Agri-Food Canada, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-4338","authenticated-orcid":false,"given":"Champa","family":"Wijekoon","sequence":"additional","affiliation":[{"name":"St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada"},{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada"},{"name":"Agriculture and Agri-Food Canada, Winnipeg, MB R2H 2A6, Canada"},{"name":"Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovemore","family":"Malunga","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Winnipeg, MB R2H 2A6, Canada"},{"name":"Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada"},{"name":"Richardson Center for Food Technology and Research, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijo Joseph","family":"Thandapilly","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Winnipeg, MB R2H 2A6, Canada"},{"name":"Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada"},{"name":"Richardson Center for Food Technology and Research, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Netticadan","sequence":"additional","affiliation":[{"name":"St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada"},{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada"},{"name":"Agriculture and Agri-Food Canada, Winnipeg, MB R2H 2A6, Canada"},{"name":"Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada"},{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"ref_1","unstructured":"NCD Risk Factor Collaboration (NCD-RisC) (2017). 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