{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:56:59Z","timestamp":1787921819925,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["PI20\/00690"],"award-info":[{"award-number":["PI20\/00690"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["PID2021-125573OB-I00"],"award-info":[{"award-number":["PID2021-125573OB-I00"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PI20\/00690"],"award-info":[{"award-number":["PI20\/00690"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PID2021-125573OB-I00"],"award-info":[{"award-number":["PID2021-125573OB-I00"]}]},{"name":"ERDF","award":["PI20\/00690"],"award-info":[{"award-number":["PI20\/00690"]}]},{"name":"ERDF","award":["PID2021-125573OB-I00"],"award-info":[{"award-number":["PID2021-125573OB-I00"]}]},{"name":"European Union","award":["PI20\/00690"],"award-info":[{"award-number":["PI20\/00690"]}]},{"name":"European Union","award":["PID2021-125573OB-I00"],"award-info":[{"award-number":["PID2021-125573OB-I00"]}]},{"name":"FUNSECO","award":["PI20\/00690"],"award-info":[{"award-number":["PI20\/00690"]}]},{"name":"FUNSECO","award":["PID2021-125573OB-I00"],"award-info":[{"award-number":["PID2021-125573OB-I00"]}]},{"name":"Fundaci\u00f3n ALIVE","award":["PI20\/00690"],"award-info":[{"award-number":["PI20\/00690"]}]},{"name":"Fundaci\u00f3n ALIVE","award":["PID2021-125573OB-I00"],"award-info":[{"award-number":["PID2021-125573OB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore, a question that remains unanswered is why some patients experience resolved NAFLD after BS and others do not. In this study, we investigated the fecal microbiota and plasma bile acids associated with NAFLD resolution in twelve morbidly obese patients undergoing BS, of whom six resolved their steatosis one year after surgery and another six did not. Results indicate that the hallmark of the gut microbiota in responder patients is a greater abundance of Bacteroides, Akkermansia, and several species of the Clostridia class (genera: Blautia, Faecalibacterium, Roseburia, Butyricicoccusa, and Clostridium), along with a decreased abundance of Actinomycetes\/Bifidobacterium and Faecalicatena. NAFLD resolution was also associated with a sustained increase in primary bile acids (particularly non-conjugated), which likely results from a reduction in bacterial gut species capable of generating secondary bile acids. We conclude that there are specific changes in gut microbiota and plasma bile acids that could contribute to resolving NAFLD in BS patients. The knowledge acquired can help to design interventions with prebiotics and\/or probiotics to promote a gut microbiome that favors NAFLD resolution.<\/jats:p>","DOI":"10.3390\/nu15143187","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:54:01Z","timestamp":1689728041000},"page":"3187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-6145","authenticated-orcid":false,"given":"\u00c1lvaro","family":"P\u00e9rez-Rubio","sequence":"first","affiliation":[{"name":"Servicio de Cirug\u00eda General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, 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V.","family":"Castell","sequence":"additional","affiliation":[{"name":"Experimental Hepatology Joint Unit, Health Research Institute La Fe-University of Valencia, 46026 Valencia, Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"CIBERehd, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Trullenque-Juan","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-9794","authenticated-orcid":false,"given":"Eugenia","family":"Pareja","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, Spain"},{"name":"Experimental 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