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Matar\u00f3-Maresme","award":["EHD16PI02"],"award-info":[{"award-number":["EHD16PI02"]}]},{"name":"Territorial Competitiveness Specialization Project (PECT) of Matar\u00f3-Maresme","award":["PI18\/00241"],"award-info":[{"award-number":["PI18\/00241"]}]},{"name":"Territorial Competitiveness Specialization Project (PECT) of Matar\u00f3-Maresme","award":["PI22\/01101"],"award-info":[{"award-number":["PI22\/01101"]}]},{"name":"Territorial Competitiveness Specialization Project (PECT) of Matar\u00f3-Maresme","award":["PRE\/161\/2019"],"award-info":[{"award-number":["PRE\/161\/2019"]}]},{"name":"Government of Catalunya-Generalitat de Catalunya within the framework of the European Regional Developments","award":["EHD16PI02"],"award-info":[{"award-number":["EHD16PI02"]}]},{"name":"Government of Catalunya-Generalitat de Catalunya within the framework of the European Regional Developments","award":["PI18\/00241"],"award-info":[{"award-number":["PI18\/00241"]}]},{"name":"Government of Catalunya-Generalitat de Catalunya within the framework of the European Regional Developments","award":["PI22\/01101"],"award-info":[{"award-number":["PI22\/01101"]}]},{"name":"Government of Catalunya-Generalitat de Catalunya within the framework of the European Regional Developments","award":["PRE\/161\/2019"],"award-info":[{"award-number":["PRE\/161\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fluid thickening is a valid therapeutic strategy for patients with oropharyngeal dysphagia (OD). The main aim of this study was to determine the therapeutic effect of the xanthan-gum-based thickener Tsururinko Quickly (TQ, Morinaga Milk Co., Tokyo, Japan) in older patients with severe OD. A total of 85 patients (83.32 \u00b1 6.75 y) with OD and a penetration\u2013aspiration score (PAS) of n \u2265 3 were studied by videofluoroscopy while swallowing duplicate 10 mL boluses at &lt;50 mPa\u00b7s, 100, 200, 400, 800, and 1600 mPa\u00b7s, to assess the safety and efficacy of swallowing and the biomechanics of a swallowing response at each viscosity level. At &lt;50 mPa\u00b7s, only 16.25% patients swallowed safely, 45% had penetrations (PAS 3\u20135), and 38.75% had aspirations (PAS 6\u20138). Fluid thickening with TQ greatly increased the prevalence of patients with safe swallowing from 62.90% at 100 mPa\u00b7s to 95.24% at 1600 mPa\u00b7s in a shear-viscosity-dependent manner. The penetrations and aspirations were significantly reduced to 3.60% and 1.19%, respectively, at 1600 mPa\u00b7s. The threshold viscosity was 100 mPa\u00b7s and the increasing viscosity above 800 mPa\u00b7s did not further improve the therapeutic effect significantly. Increasing the shear viscosity significantly reduced the time to laryngeal vestibule closure (\u221216.70%), increased the time to upper oesophageal sphincter opening (+26.88%), and reduced the pharyngeal bolus velocity (\u221231.62%) without affecting the pharyngeal residue. TQ has a strong shear-viscosity-dependent effect on the safety of swallowing in older patients with severe OD without increasing the pharyngeal residue. The therapeutic range for TQ is 100\u2013800 mPa\u00b7s, with 200 and 800 mPa\u00b7s being the optimal doses to cover the needs of older patients with OD.<\/jats:p>","DOI":"10.3390\/nu15143279","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:27:32Z","timestamp":1690248452000},"page":"3279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Shear-Viscosity-Dependent Effect of a Gum-Based Thickening Product on the Safety of Swallowing in Older Patients with Severe Oropharyngeal Dysphagia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-1150","authenticated-orcid":false,"given":"Mireia","family":"Bolivar-Prados","sequence":"first","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"R&D Division, Morinaga Milk Industry Co., Ltd., Zama-City 222-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-7948","authenticated-orcid":false,"given":"Noemi","family":"Tomsen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viridiana","family":"Arreola","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-3475","authenticated-orcid":false,"given":"Weslania","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Riera","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"R&D Division, Morinaga Milk Industry Co., Ltd., Zama-City 222-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-2855","authenticated-orcid":false,"given":"Kazuhiro","family":"Miyaji","sequence":"additional","affiliation":[{"name":"R&D Division, Morinaga Milk Industry Co., Ltd., Zama-City 222-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"R&D Division, Morinaga Milk Industry Co., Ltd., Zama-City 222-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kayashita","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Hiroshima 734-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-8560","authenticated-orcid":false,"given":"Pere","family":"Clav\u00e9","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref_1","first-page":"5","article-title":"Dysphagia: Current reality and scope of the problem","volume":"12","author":"Shaker","year":"2015","journal-title":"Nat. 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