{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:11:41Z","timestamp":1793157101467,"version":"4.5.0"},"reference-count":130,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","award":["8050-51000-089-01S"],"award-info":[{"award-number":["8050-51000-089-01S"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY028559"],"award-info":[{"award-number":["EY028559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY026979"],"award-info":[{"award-number":["EY026979"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY021212"],"award-info":[{"award-number":["EY021212"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008097","name":"Thome Memorial Foundation","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/100008097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["PID2020-119466RB-I00"],"award-info":[{"award-number":["PID2020-119466RB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Age is the biggest risk factor for cataracts, and aberrant oxidative modifications are correlated with age-related cataracts, suggesting that proper redox regulation is important for lens clarity. The lens has very high levels of antioxidants, including ascorbate and glutathione that aid in keeping the lens clear, at least in young animals and humans. We summarize current functional and genetic data supporting the hypothesis that impaired regulation of oxidative stress leads to redox dysregulation and cataract. We will focus on the essential endogenous antioxidant glutathione and the exogenous antioxidant vitamin C\/ascorbate. Additionally, gene expression in response to oxidative stress is regulated in part by the transcription factor NRF2 (nuclear factor erythroid 2-related factor 2 [NFE2L2]), thus we will summarize our data regarding cataracts in Nrf2-\/- mice. In this work, we discuss the function and integration of these capacities with the objective of maintaining lens clarity.<\/jats:p>","DOI":"10.3390\/nu15153375","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:48:50Z","timestamp":1690768130000},"page":"3375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling Pathway"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-1581","authenticated-orcid":false,"given":"Eloy","family":"Bejarano","sequence":"first","affiliation":[{"name":"JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"},{"name":"School of Health Sciences and Veterinary, Universidad CEU Cardenal Herrera, CEU Universities, 46113 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Weinberg","sequence":"additional","affiliation":[{"name":"JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Clark","sequence":"additional","affiliation":[{"name":"JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-1825","authenticated-orcid":false,"given":"Allen","family":"Taylor","sequence":"additional","affiliation":[{"name":"JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"},{"name":"Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA"},{"name":"Department of Ophthalmology, School of Medicine, Tufts University, Boston, MA 02111, USA"},{"name":"Department of Developmental, Chemical and Molecular Biology, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-6743","authenticated-orcid":false,"given":"Sheldon","family":"Rowan","sequence":"additional","affiliation":[{"name":"JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"},{"name":"Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA"},{"name":"Department of Ophthalmology, School of Medicine, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Whitcomb","sequence":"additional","affiliation":[{"name":"JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"Pascolini","year":"2011","journal-title":"Br. 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