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stages on the long-term health of offspring. Intrauterine metabolic perturbations can profoundly impact organogenesis in offspring, particularly affecting cardiac development and giving rise to potential structural and functional abnormalities. In this discussion, we contemplate the existing understanding regarding the impact of maternal metabolic disorders, such as obesity, diabetes, or undernutrition, on the developmental and functional aspects of the offspring\u2019s heart. This influence has the potential to contribute to the susceptibility of offspring to cardiovascular health issues. Alteration in the nutritional milieu can influence mitochondrial function in the developing hearts of offspring, while also serving as signaling molecules that directly modulate gene expression. Moreover, metabolic disorders can exert influence on cardiac development-related genes epigenetically through DNA methylation, levels of histone modifications, microRNA expression, and other factors. However, the comprehensive understanding of the mechanistic underpinnings of these phenomena remains incomplete. Further investigations in this domain hold profound clinical significance, as they can contribute to the enhancement of public health and the prevention of cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/nu15153388","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:48:50Z","timestamp":1690768130000},"page":"3388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Research Progress of Maternal Metabolism on Cardiac Development and Function in Offspring"],"prefix":"10.3390","volume":"15","author":[{"given":"Zhuoran","family":"Ren","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200001, China"},{"name":"Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Luo","sequence":"additional","affiliation":[{"name":"Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China"},{"name":"Shanghai First Maternity and Infant Hospital, Shanghai 200126, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Cui","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200001, China"},{"name":"Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1191-4679","authenticated-orcid":false,"given":"Yunhui","family":"Tang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200001, China"},{"name":"Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200001, China"},{"name":"Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0099-9980","authenticated-orcid":false,"given":"Guolian","family":"Ding","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200001, China"},{"name":"Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-genom-083118-015012","article-title":"Heart Development and Congenital Structural Heart Defects","volume":"22","author":"Houyel","year":"2021","journal-title":"Annu. 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