{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:45:26Z","timestamp":1791726326790,"version":"4.3.4"},"reference-count":182,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It is well known that neurodegenerative diseases\u2019 development and progression are accelerated due to oxidative stress and inflammation, which result in impairment of mitochondrial function, cellular damage, and dysfunction of DNA repair systems. The increased consumption of antioxidants can postpone the development of these disorders and improve the quality of patients\u2019 lives who have already been diagnosed with neurodegenerative diseases. Prolonging life span in developed countries contributes to an increase in the incidence ratio of chronic age-related neurodegenerative disorders, such as PD (Parkinson\u2019s disease), AD (Alzheimer\u2019s disease), or numerous forms of age-related dementias. Dietary supplementation with neuroprotective plant-derived polyphenols might be considered an important element of healthy aging. Some polyphenols improve cognition, mood, visual functions, language, and verbal memory functions. Polyphenols bioavailability differs greatly from one compound to another and is determined by solubility, degree of polymerization, conjugation, or glycosylation resulting from chemical structure. It is still unclear which polyphenols are beneficial because their potential depends on efficient transport across the BBB (blood-brain barrier), bioavailability, and stability in the CNS (central nervous system). Polyphenols improve brain functions by having a direct impact on cells and processes in the CNS. For a direct effect, polyphenolic compounds must be able to overcome the BBB and accumulate in brain tissue. In this review, the latest achievements in studies (animal models and clinical trials) on the effect of polyphenols on brain activity and function are described. The beneficial impact of plant polyphenols on the brain may be summarized by their role in increasing brain plasticity and related cognition improvement. As reversible MAO (monoamine oxidase) inhibitors, polyphenols are mood modulators and improve neuronal self-being through an increase in dopamine, serotonin, and noradrenaline amounts in the brain tissue. After analyzing the prohealth effects of various eating patterns, it was postulated that their beneficial effects result from synergistic interactions between individual dietary components. Polyphenols act on the brain endothelial cells and improve the BBB\u2019s integrity and reduce inflammation, thus protecting the brain from additional injury during stroke or autoimmune diseases. Polyphenolic compounds are capable of lowering blood pressure and improving cerebral blood flow. Many studies have revealed that a nutritional model based on increased consumption of antioxidants has the potential to ameliorate the cognitive impairment associated with neurodegenerative disorders. Randomized clinical trials have also shown that the improvement of cognitive functions resulting from the consumption of foods rich in flavonoids is independent of age and health conditions. For therapeutic use, sufficient quantities of polyphenols must cross the BBB and reach the brain tissue in active form. An important issue in the direct action of polyphenols on the CNS is not only their penetration through the BBB, but also their brain metabolism and localization. The bioavailability of polyphenols is low. The most usual oral administration also conflicts with bioavailability. The main factors that limit this process and have an effect on therapeutic efficacy are: selective permeability across BBB, gastrointestinal transformations, poor absorption, rapid hepatic and colonic metabolism, and systemic elimination. Thus, phenolic compounds have inadequate bioavailability for human applications to have any beneficial effects. In recent years, new strategies have been attempted in order to exert cognitive benefits and neuroprotective effects. Converting polyphenols into nanostructures is one of the theories proposed to enhance their bioavailability. The following nanoscale delivery systems can be used to encapsulate polyphenols: nanocapsules, nanospheres, micelles, cyclodextrins, solid lipid nanoparticles, and liposomes. It results in great expectations for the wide-scale and effective use of polyphenols in the prevention of neurodegenerative diseases. Thus far, only natural polyphenols have been studied as neuroprotectors. Perhaps some modification of the chemical structure of a given polyphenol may increase its neuroprotective activity and transportation through the BBB. However, numerous questions should be answered before developing neuroprotective medications based on plant polyphenols.<\/jats:p>","DOI":"10.3390\/nu15153454","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T09:28:04Z","timestamp":1691141284000},"page":"3454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":260,"title":["Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development"],"prefix":"10.3390","volume":"15","author":[{"given":"Izabela","family":"Grabska-Koby\u0142ecka","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Medical University of Lodz, Mazowiecka 6\/8 Street, 92-215 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-7652","authenticated-orcid":false,"given":"Piotr","family":"Szpakowski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-1099","authenticated-orcid":false,"given":"Aleksandra","family":"Kr\u00f3l","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology, Medical University of Lodz, Mazowiecka 6\/8 Street, 92-215 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Ksi\u0105\u017cek-Winiarek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Koby\u0142ecki","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Lab, Copernicus Hospital, Pabianicka Str. 62, 93-513 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-1494","authenticated-orcid":false,"given":"Andrzej","family":"G\u0142\u0105bi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-6930","authenticated-orcid":false,"given":"Dariusz","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Medical University of Lodz, Mazowiecka 6\/8 Street, 92-215 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"ref_1","first-page":"376","article-title":"Oxidative stress in neurodegenerative diseases","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/biof.5520130132","article-title":"Cognitive impairment and oxidative stress in the elderly: Results of epidemiological studies","volume":"13","author":"Berr","year":"2000","journal-title":"BioFactors"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s11064-008-9808-4","article-title":"Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging","volume":"34","author":"Head","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12974-019-1403-x","article-title":"Blood-brain barrier permeability and physical exercise","volume":"16","author":"Szarmach","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The Role of Oxidative Stress in Neurodegenerative Diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., and Restani, P. (2021). Polyphenols and Human Health: The Role of Bioavailability. Nutrients, 13.","DOI":"10.3390\/nu13010273"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1038\/s41598-017-11512-6","article-title":"Polyphenols journey through blood-brain barrier towards neuronal protection","volume":"7","author":"Figueira","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3233\/NUA-2012-0005","article-title":"Flavonoid transport across blood-brain barrier: Implication for their direct neuroprotective actions","volume":"1","author":"Faria","year":"2012","journal-title":"Nutr. Aging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2019.10.062","article-title":"Alzheimer\u2019s Disease and Vascular Aging: JACC Focus Seminar","volume":"75","author":"Iadecola","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"R741","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a Risk Factor for Disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s13659-022-00339-y","article-title":"Antiaging agents: Safe interventions to slow aging and healthy life span extension","volume":"12","author":"Liu","year":"2022","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.physbeh.2011.02.013","article-title":"Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions","volume":"103","author":"Field","year":"2011","journal-title":"Physiol. Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1177\/0269881109106923","article-title":"Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort","volume":"24","author":"Scholey","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3945\/jn.111.144428","article-title":"Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later","volume":"142","author":"Fezeu","year":"2012","journal-title":"J. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3945\/jn.108.095182","article-title":"Intake of Flavonoid-Rich Wine, Tea, and Chocolate by Elderly Men and Women Is Associated with Better Cognitive Test Performance","volume":"139","author":"Nurk","year":"2009","journal-title":"J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/gerona\/gly166","article-title":"Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study","volume":"74","author":"Bensalem","year":"2019","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/acm.2005.11.305","article-title":"A Double-Blinded, Placebo-Controlled, Randomized Trial of the Neuropsychologic Efficacy of Cranberry Juice in a Sample of Cognitively Intact Older Adults: Pilot Study Findings","volume":"11","author":"Crews","year":"2005","journal-title":"J. Altern. Complement. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1021\/jf9029332","article-title":"Blueberry Supplementation Improves Memory in Older Adults","volume":"58","author":"Krikorian","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1017\/S0007114509992364","article-title":"Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment","volume":"103","author":"Krikorian","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"120356","DOI":"10.1016\/j.jns.2022.120356","article-title":"Protective and anti-oxidative effects of curcumin and resveratrol on A\u03b2-oligomer-induced damage in the SH-SY5Y cell line","volume":"441","author":"Yu","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1801230","DOI":"10.1002\/mnfr.201801230","article-title":"Epigallocatechin-3-Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4\/NF-\u03baB Pathway","volume":"63","author":"Zhong","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/S1353-8020(09)70555-3","article-title":"P2.204 A randomized, double-blind, placebo-controlled, delayed start study to assess safty, tolerability and efflcacy of green tea polyphenols in Parkinson\u2019s disease","volume":"15","author":"Chan","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kobayashi, H., Murata, M., Kawanishi, S., and Oikawa, S. (2020). Polyphenols with Anti-Amyloid \u03b2 Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103561"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuint.2015.07.003","article-title":"Review","volume":"89","author":"Pandareesh","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2174\/1570159X14666161026151545","article-title":"Polyphenols Beyond Barriers: A Glimpse into the Brain","volume":"15","author":"Figueira","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1179\/1476830511Y.0000000035","article-title":"Natural mood foods: The actions of polyphenols against psychiatric and cognitive disorders","volume":"15","author":"Nguyen","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"28587","DOI":"10.1074\/jbc.M110.125740","article-title":"Regulation of Dendritic Development by BDNF Requires Activation of CRTC1 by Glutamate","volume":"285","author":"Finsterwald","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/10284150400020482","article-title":"Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats","volume":"7","author":"Casadesus","year":"2004","journal-title":"Nutr. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2013.01.032","article-title":"Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson\u2019s disease in rats","volume":"236","author":"Karuppagounder","year":"2013","journal-title":"Neuroscience"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00213-008-1300-y","article-title":"Antidepressant activity of curcumin: Involvement of serotonin and dopamine system","volume":"201","author":"Kulkarni","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2006.09.009","article-title":"Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB","volume":"1122","author":"Xu","year":"2006","journal-title":"Brain Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2008.04.008","article-title":"Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels","volume":"45","author":"Williams","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5775040","DOI":"10.1155\/2021\/5775040","article-title":"Yunnan Black Tea Flavonoids Can Improve Cognitive Dysfunction in Septic Mice by Activating SIRT1","volume":"2021","author":"Mai","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3177\/jnsv.52.266","article-title":"Favorable Effects of Tea on Reducing the Cognitive Deficits and Brain Morphological Changes in Senescence-Accelerated Mice","volume":"52","author":"Chan","year":"2006","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2353\/ajpath.2009.090417","article-title":"Phenolic Compounds Prevent Alzheimer\u2019s Pathology through Different Effects on the Amyloid-\u03b2 Aggregation Pathway","volume":"175","author":"Hamaguchi","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0006-8993(02)03543-6","article-title":"Resveratrol protects against global cerebral ischemic injury in gerbils","volume":"958","author":"Wang","year":"2002","journal-title":"Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"108579","DOI":"10.1016\/j.jnutbio.2020.108579","article-title":"Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1\/NF-\u03baB pathway in neonatal mice","volume":"90","author":"Tang","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1179\/016164110X12700393823570","article-title":"Effects of green tea polyphenols on caveolin-1 of microvessel fragments in rats with cerebral ischemia","volume":"32","author":"Zhang","year":"2010","journal-title":"Neurol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2174\/1567202617666200517105727","article-title":"A Polyphenolic Complex Attenuates Inflammatory Response and Blood- Brain Barrier Disruption","volume":"17","author":"Bian","year":"2020","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/ptr.6849","article-title":"Lychee seed polyphenol protects the blood\u2013brain barrier through inhibiting A\u03b2(25\u201335)-induced NLRP3 inflammasome activation via the AMPK\/mTOR\/ULK1-mediated autophagy in bEnd.3 cells and APP\/PS1 mice","volume":"35","author":"Xiong","year":"2021","journal-title":"Phyther. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fncel.2019.00030","article-title":"Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome","volume":"13","author":"Yu","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/FBP.0000000000000076","article-title":"Caffeic acid protects mice from memory deficits induced by focal cerebral ischemia","volume":"25","author":"Fonteles","year":"2014","journal-title":"Behav. Pharmacol."},{"key":"ref_44","first-page":"8361858","article-title":"Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B","volume":"2019","author":"Zhang","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00787-006-0538-3","article-title":"Treatment of ADHD with French maritime pine bark extract, Pycnogenol\u00ae","volume":"15","author":"Rohdewald","year":"2006","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Carbone, M., Lulli, D., Passarelli, F., and Pastore, S. (2018). Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092652"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mvr.2015.12.008","article-title":"Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I\/R","volume":"106","author":"Li","year":"2016","journal-title":"Microvasc. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4155\/fmc-2018-0172","article-title":"Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models","volume":"10","author":"Hou","year":"2018","journal-title":"Future Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Testa, G., Gamba, P., Badilli, U., Gargiulo, S., Maina, M., Guina, T., Calfapietra, S., Biasi, F., Cavalli, R., and Poli, G. (2014). Loading into Nanoparticles Improves Quercetin\u2019s Efficacy in Preventing Neuroinflammation Induced by Oxysterols. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096795"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.abb.2014.05.025","article-title":"Specific localization of quercetin-3-O-glucuronide in human brain","volume":"557","author":"Ishisaka","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bcp.2009.03.031","article-title":"Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23.5 cells","volume":"78","author":"Wang","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bcp.2017.04.004","article-title":"Natural product-based amyloid inhibitors","volume":"139","author":"Velander","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Vassallo, N. (2015). Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases, Springer International Publishing.","DOI":"10.1007\/978-3-319-18365-7"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin Inhibits Formation of Amyloid \u03b2 Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3233\/JAD-170351","article-title":"Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro","volume":"60","author":"Rane","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1979","DOI":"10.1212\/WNL.0000000000005607","article-title":"Pattern of polyphenol intake and the long-term risk of dementia in older persons","volume":"90","author":"Gaudout","year":"2018","journal-title":"Neurology"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Aryal, S., Skinner, T., Bridges, B., and Weber, J.T. (2020). The Pathology of Parkinson\u2019s Disease and Potential Benefit of Dietary Polyphenols. Molecules, 25.","DOI":"10.3390\/molecules25194382"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/1028415X.2022.2073107","article-title":"The role of nutrition on Parkinson\u2019s disease: A systematic review","volume":"26","author":"Bianchi","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuint.2005.10.010","article-title":"Structure\u2013activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives","volume":"48","author":"Lu","year":"2006","journal-title":"Neurochem. Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/WNL.0b013e31824f7fc4","article-title":"Habitual intake of dietary flavonoids and risk of Parkinson disease","volume":"78","author":"Gao","year":"2012","journal-title":"Neurology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7769355","DOI":"10.1155\/2022\/7769355","article-title":"Quercetin Protects against MPP+\/MPTP-Induced Dopaminergic Neuron Death in Parkinson\u2019s Disease by Inhibiting Ferroptosis","volume":"2022","author":"Lin","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00394-018-1843-6","article-title":"The effects of acute wild blueberry supplementation on the cognition of 7\u201310-year-old schoolchildren","volume":"58","author":"Barfoot","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Whyte, A.R., Cheng, N., Butler, L.T., Lamport, D.J., and Williams, C.M. (2019). Flavonoid-Rich Mixed Berries Maintain and Improve Cognitive Function Over a 6 h Period in Young Healthy Adults. Nutrients, 11.","DOI":"10.3390\/nu11112685"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Godos, J., Caraci, F., Castellano, S., Currenti, W., Galvano, F., Ferri, R., and Grosso, G. (2020). Association Between Dietary Flavonoids Intake and Cognitive Function in an Italian Cohort. Biomolecules, 10.","DOI":"10.3390\/biom10091300"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ibror.2020.05.001","article-title":"Does calorie restriction improve cognition?","volume":"9","author":"Dias","year":"2020","journal-title":"IBRO Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2019.01.018","article-title":"Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential","volume":"29","author":"Madeo","year":"2019","journal-title":"Cell Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1017\/jns.2018.10","article-title":"Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice","volume":"7","author":"Bensalem","year":"2018","journal-title":"J. Nutr. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Grabska-Kobylecka, I., Kaczmarek-Bak, J., Figlus, M., Prymont-Przyminska, A., Zwolinska, A., Sarniak, A., Wlodarczyk, A., Glabinski, A., and Nowak, D. (2020). The Presence of Caffeic Acid in Cerebrospinal Fluid: Evidence That Dietary Polyphenols Can Cross the Blood-Brain Barrier in Humans. Nutrients, 12.","DOI":"10.3390\/nu12051531"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1089\/jmf.2017.4161","article-title":"Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic\u2013Pituitary\u2013Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress","volume":"21","author":"Lee","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Rothenberg, D.O., and Zhang, L. (2019). Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption. Nutrients, 11.","DOI":"10.3390\/nu11061361"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1515\/revneuro-2016-0072","article-title":"Hippocampal BDNF in physiological conditions and social isolation","volume":"28","author":"Zaletel","year":"2017","journal-title":"Rev. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1139\/apnm-2020-0014","article-title":"Rosemary extract increases neuronal cell glucose uptake and activates AMPK","volume":"46","author":"Baron","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"D\u2019Angelo, S., Mele, E., Di Filippo, F., Viggiano, A., and Meccariello, R. (2021). Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031243"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnmol.2015.00024","article-title":"Plant polyphenols as inhibitors of NF-\u03baB induced cytokine production\u2014A potential anti-inflammatory treatment for Alzheimer\u2019s disease?","volume":"8","author":"Karunaweera","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12964-021-00704-3","article-title":"Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation","volume":"19","author":"Sonawane","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3389\/fnins.2016.00598","article-title":"Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells","volume":"10","author":"He","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_77","first-page":"1138","article-title":"Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+-calpain-p25-CDK5 pathway in HT22 cells","volume":"41","author":"Shen","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"111253","DOI":"10.1016\/j.biopha.2021.111253","article-title":"Mechanistic new insights of flavonols on neurodegenerative diseases","volume":"137","author":"Tahir","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Haskell-Ramsay, C.F., Schmitt, J., and Actis-Goretta, L. (2018). The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow. Nutrients, 10.","DOI":"10.3390\/nu10080986"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3164\/jcbn.11-010FR","article-title":"Cocoa flavanols: Effects on vascular nitric oxide and blood pressure","volume":"48","author":"Fraga","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuint.2015.08.002","article-title":"The mechanisms of action of flavonoids in the brain: Direct versus indirect effects","volume":"89","author":"Rendeiro","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Marunaka, Y., Marunaka, R., Sun, H., Yamamoto, T., Kanamura, N., Inui, T., and Taruno, A. (2017). Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules, 22.","DOI":"10.3390\/molecules22020209"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8526438","DOI":"10.1155\/2017\/8526438","article-title":"Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke","volume":"2017","author":"Cheng","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3945\/ajcn.113.066639","article-title":"Intake and time dependence of blueberry flavonoid\u2013induced improvements in vascular function: A randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity","volume":"98","author":"Rendeiro","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0735-1097(03)00994-X","article-title":"The clinical implications of endothelial dysfunction","volume":"42","author":"Widlansky","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.afnr.2019.08.001","article-title":"Chapter One\u2014Polyphenols in the management of brain disorders: Modulation of the microbiota-gut-brain axis","volume":"Volume 91","year":"2020","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1038\/s41467-019-09884-6","article-title":"Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis","volume":"10","author":"Ramakrishna","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Chang, Y.-C., Ching, Y.-H., Chiu, C.-C., Liu, J.-Y., Hung, S.-W., Huang, W.-C., Huang, Y.-T., and Chuang, H.-L. (2017). TLR2 and interleukin-10 are involved in Bacteroides fragilis-mediated prevention of DSS-induced colitis in gnotobiotic mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180025"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/mi.2010.29","article-title":"A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease","volume":"3","author":"Mielcarz","year":"2010","journal-title":"Mucosal Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41586-020-2199-7","article-title":"The gut\u2013brain axis mediates sugar preference","volume":"580","author":"Tan","year":"2020","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"7902874","DOI":"10.1155\/2019\/7902874","article-title":"The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats","volume":"2019","author":"Lv","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Koudoufio, M., Desjardins, Y., Feldman, F., Spahis, S., Delvin, E., and Levy, E. (2020). Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?. Antioxidants, 9.","DOI":"10.3390\/antiox9100982"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.4103\/1673-5374.241429","article-title":"Polyphenols-gut microbiota interplay and brain neuromodulation","volume":"13","author":"Filosa","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1096\/fj.201903102RR","article-title":"Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high-fat diet-fed mice","volume":"34","author":"Lu","year":"2020","journal-title":"FASEB J."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Guirro, M., Gual-Grau, A., Gibert-Ramos, A., Alcaide-Hidalgo, J.M., Canela, N., Arola, L., and Mayneris-Perxachs, J. (2020). Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet. Antioxidants, 9.","DOI":"10.3390\/antiox9010079"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Estruel-Amades, S., Massot-Cladera, M., P\u00e9rez-Cano, F.J., Franch, \u00c0., Castell, M., and Camps-Bossacoma, M. (2019). Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats. Nutrients, 11.","DOI":"10.3390\/nu11020324"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1039\/c3fo60630a","article-title":"Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity","volume":"5","author":"Qiao","year":"2014","journal-title":"Food Funct."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1021\/jf100836j","article-title":"Determination of Dihydroresveratrol in Rat Plasma by HPLC","volume":"58","author":"Juan","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e13881","DOI":"10.14814\/phy2.13881","article-title":"The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice","volume":"6","author":"Brandt","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s00449-016-1662-1","article-title":"Bioconversion of piceid to resveratrol by selected probiotic cell extracts","volume":"39","author":"Schuster","year":"2016","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1471-4159.2003.01652.x","article-title":"Interaction between flavonoids and the blood\u2013brain barrier: In vitro studies","volume":"85","author":"Youdim","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2012.03696.x","article-title":"Overview and introduction: The blood\u2013brain barrier in health and disease","volume":"53","author":"Abbott","year":"2012","journal-title":"Epilepsia"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte\u2013endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Watson, R.R., Preedy, V.R., and Zibadi, S. (2014). Polyphenols in Human Health and Disease, Academic Press.","DOI":"10.1007\/978-1-62703-044-1"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.freeradbiomed.2003.11.023","article-title":"Flavonoid permeability across an in situ model of the blood\u2013brain barrier","volume":"36","author":"Youdim","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12263-011-0255-5","article-title":"Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations","volume":"7","author":"Schaffer","year":"2012","journal-title":"Genes Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1023\/A:1012200805593","article-title":"Transport and Metabolism of the Tea Flavonoid (\u2013)-Epicatechin by the Human Intestinal Cell Line Caco-2","volume":"18","author":"Vaidyanathan","year":"2001","journal-title":"Pharm. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11095-008-9735-8","article-title":"V Curcumin Inhibits the Activity of ABCG2\/BCRP1, a Multidrug Resistance-Linked ABC Drug Transporter in Mice","volume":"26","author":"Shukla","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.foodchem.2012.12.021","article-title":"Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP\/ABCG2)","volume":"138","author":"Tan","year":"2013","journal-title":"Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/jps.21851","article-title":"Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response","volume":"99","author":"Alvarez","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.1074\/jbc.M109.060061","article-title":"AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-\u03b2 Peptide Metabolism","volume":"285","author":"Vingtdeux","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Suominen, T., Piepponen, T.P., and Kostiainen, R. (2015). Permeation of Dopamine Sulfate through the Blood-Brain Barrier. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133904"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1089\/jmf.2009.0157","article-title":"Pharmacokinetics and Tissue Distribution of 14C-Labeled Grape Polyphenols in the Periphery and the Central Nervous System Following Oral Administration","volume":"13","author":"Janle","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/carcin\/19.10.1771","article-title":"Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue","volume":"19","author":"Suganuma","year":"1998","journal-title":"Carcinogenesis"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0891-5849(02)01137-1","article-title":"Uptake and metabolism of epicatechin and its access to the brain after oral ingestion","volume":"33","author":"Kuhnle","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0378-4347(98)00204-7","article-title":"Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography","volume":"714","author":"Peng","year":"1998","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Lao, C.D., Ruffin, M.T., Normolle, D., Heath, D.D., Murray, S.I., Bailey, J.M., Boggs, M.E., Crowell, J., Rock, C.L., and Brenner, D.E. (2006). Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med., 6.","DOI":"10.1186\/1472-6882-6-10"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Szwajgier, D., Borowiec, K., and Pustelniak, K. (2017). The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action. Nutrients, 9.","DOI":"10.3390\/nu9050477"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/10284150600637739","article-title":"Do flavan-3-ols from green tea reach the human brain?","volume":"9","author":"Zini","year":"2006","journal-title":"Nutr. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral curcumin for Alzheimer\u2019s disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.freeradbiomed.2011.06.017","article-title":"Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats","volume":"51","author":"Ishisaka","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Cichon, N., Saluk-Bijak, J., Gorniak, L., Przyslo, L., and Bijak, M. (2020). Flavonoids as a Natural Enhancer of Neuroplasticity\u2014An Overview of the Mechanism of Neurorestorative Action. Antioxidants, 9.","DOI":"10.3390\/antiox9111035"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3945\/ajcn.2009.28641","article-title":"Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation","volume":"91","author":"Kennedy","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.0385-14.2014","article-title":"Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults","volume":"34","author":"Witte","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.clnu.2020.08.025","article-title":"Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study","volume":"40","author":"Howe","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Kennedy, S.J., Ryan, L., and Clegg, M.E. (2020). The Effects of a Functional Food Breakfast on Gluco-Regulation, Cognitive Performance, Mood, and Satiety in Adults. Nutrients, 12.","DOI":"10.3390\/nu12102974"},{"key":"ref_129","first-page":"105","article-title":"Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment","volume":"11","author":"Witte","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s40120-021-00271-2","article-title":"Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial","volume":"10","author":"Gu","year":"2021","journal-title":"Neurol. Ther."},{"key":"ref_131","first-page":"376","article-title":"Effect of curcumin on the induction of glutathione S-transferases and NADP(H):quinone oxidoreductase and its possible mechanism of action","volume":"42","author":"Ye","year":"2007","journal-title":"Yao Xue Xue Bao"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2174\/1871530319666190212170140","article-title":"The Neuromodulatory Effects of \u03c9-3 Fatty Acids and Nano-Curcumin on the COX-2\/iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms","volume":"19","author":"Abdolahi","year":"2019","journal-title":"Endocr. Metab. Immune Disord.-Drug Targets"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"101256","DOI":"10.1016\/j.ctcp.2020.101256","article-title":"The effects of nano-curcumin supplementation on Th1\/Th17 balance in migraine patients: A randomized controlled clinical trial","volume":"41","author":"Djalali","year":"2020","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/pr.56.3.1","article-title":"Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine","volume":"56","author":"Eisenhofer","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1258\/000456304322664663","article-title":"Measurement of catecholamines and their metabolites","volume":"41","author":"Peaston","year":"2004","journal-title":"Ann. Clin. Biochem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0009-8981(82)90125-5","article-title":"Determination of p-hydroxyphenylacetic acid in cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection","volume":"123","author":"Kobayashi","year":"1982","journal-title":"Clin. Chim. Acta"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bcp.2018.05.016","article-title":"Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors","volume":"154","author":"Squillaro","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1039\/B801739P","article-title":"Nano- and micro-structured assemblies for encapsulation of food ingredients","volume":"38","author":"Augustin","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref_139","first-page":"139","article-title":"Polyphenols nanoencapsulation for therapeutic applications","volume":"5","author":"Conte","year":"2016","journal-title":"Biomol. Res. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnut.2016.00031","article-title":"Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer\u2019s and Parkinson\u2019s Disease","volume":"3","author":"Caruana","year":"2016","journal-title":"Front. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2015.01.027","article-title":"The flavonoid quercetin ameliorates Alzheimer\u2019s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer\u2019s disease model mice","volume":"93","author":"Osorio","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.2174\/09298673113209990120","article-title":"Bioavailability of quercetin: Problems and promises","volume":"20","author":"Cai","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.colsurfb.2016.06.053","article-title":"Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds","volume":"146","author":"Esfanjani","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/13102818.2017.1347523","article-title":"In vitro protective effects of encapsulated quercetin in neuronal models of oxidative stress injury","volume":"31","author":"Aluani","year":"2017","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"101795","DOI":"10.1016\/j.jchemneu.2020.101795","article-title":"Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer\u2019s disease","volume":"107","author":"Rifaai","year":"2020","journal-title":"J. Chem. Neuroanat."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"598617","DOI":"10.3389\/fnins.2020.598617","article-title":"Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer\u2019s Disease via Antioxidant Genes, APP Gene, and miRNA-101","volume":"14","author":"Esmaeili","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jconrel.2007.12.018","article-title":"Potential of solid lipid nanoparticles in brain targeting","volume":"127","author":"Kaur","year":"2008","journal-title":"J. Control. Release"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fnins.2020.00494","article-title":"Nanotechnology: A promising approach for delivery of neuroprotective drugs","volume":"14","author":"Naqvi","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Loureiro, J.A., Andrade, S., Duarte, A., Neves, A.R., Queiroz, J.F., Nunes, C., Sevin, E., Fenart, L., Gosselet, F., and Coelho, M.A.N. (2017). Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer\u2019s Disease. Molecules, 22.","DOI":"10.3390\/molecules22020277"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12017-013-8261-y","article-title":"Curcumin Nanoparticles Attenuate Neurochemical and Neurobehavioral Deficits in Experimental Model of Huntington\u2019s Disease","volume":"16","author":"Sandhir","year":"2014","journal-title":"NeuroMol. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/acschemneuro.6b00207","article-title":"Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood\u2013Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson\u2019s Disease","volume":"7","author":"Kundu","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Abdul Rahim, R., Jayusman, P.A., Muhammad, N., Ahmad, F., Mokhtar, N., Naina Mohamed, I., Mohamed, N., and Shuid, A.N. (2019). Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16244962"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.3390\/app11094305","article-title":"Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimer\u2019s disease","volume":"11","author":"Cano","year":"2021","journal-title":"Appl. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40263-016-0405-9","article-title":"Crossing the blood\u2013brain barrier: Recent advances in drug delivery to the brain","volume":"31","author":"Patel","year":"2017","journal-title":"CNS Drugs"},{"key":"ref_155","unstructured":"(2023, May 01). FDA Current Good Manufacturing Practice (CGMP) Regulations, Available online: https:\/\/www.fda.gov\/drugs\/pharmaceutical-quality-resources\/current-good-manufacturing-practice-cgmp-regulations."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/pharmaceutics13040500","article-title":"PLGA nanoparticle-based formulations to cross the blood\u2013brain barrier for drug delivery: From R&D to cGMP","volume":"13","author":"Zhi","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Mathew, A., Aravind, A., Fukuda, T., Hasumura, T., Nagaoka, Y., Yoshida, Y., Maekawa, T., Venugopal, K., and Kumar, D.S. (2011, January 15\u201318). Curcumin nanoparticles- a gateway for multifaceted approach to tackle Alzheimer\u2019s disease. Proceedings of the 2011 11th IEEE International Conference on Nanotechnology, Portland, OR, USA.","DOI":"10.1109\/NANO.2011.6144336"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Mathew, A., Fukuda, T., Nagaoka, Y., Hasumura, T., Morimoto, H., Yoshida, Y., Maekawa, T., Venugopal, K., and Kumar, D.S. (2012). Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer\u2019s Disease. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032616"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1021\/nn405077y","article-title":"Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer\u2019s Disease Model via Canonical Wnt\/\u03b2-Catenin Pathway","volume":"8","author":"Tiwari","year":"2014","journal-title":"ACS Nano"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-2010-101374","article-title":"Neuroprotective and Neurorescue Effects of a Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurcTM) in the Neuronal Cell Culture and Animal Model: Implications for Alzheimer\u2019s disease","volume":"23","author":"Ray","year":"2011","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ghosh, A., Sarkar, S., Mandal, A.K., and Das, N. (2013). Neuroprotective role of nanoencapsulated quercetin in combating ischemia-reperfusion induced neuronal damage in young and aged rats. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057735"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.colsurfb.2016.08.052","article-title":"Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer\u2019s disease","volume":"148","author":"Sun","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.3390\/molecules25204613","article-title":"Nanoformulations to enhance the bioavailability and physiological functions of polyphenols","volume":"25","author":"Yang","year":"2020","journal-title":"Molecules"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nano.2007.12.001","article-title":"Anxiety and cognitive effects of quercetin liposomes in rats","volume":"4","author":"Priprem","year":"2008","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuropharm.2011.09.016","article-title":"\u03b1-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates \u03b2-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation","volume":"62","author":"Wang","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.nano.2015.10.021","article-title":"Transferrin-modified liposome promotes \u03b1-mangostin to penetrate the blood\u2013brain barrier","volume":"12","author":"Chen","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"326S","DOI":"10.1093\/ajcn\/81.1.326S","article-title":"Risks and safety of polyphenol consumption","volume":"81","author":"Mennen","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_168","first-page":"1","article-title":"Polyphenols as dietary supplements: A double-edged sword","volume":"2","author":"Martin","year":"2009","journal-title":"Nutr. Diet. Suppl."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1742-7843.2004.pto_950407.x","article-title":"In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity","volume":"95","author":"Weisburg","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2008.01.028","article-title":"Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?","volume":"476","author":"Halliwell","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1080\/10715760601091659","article-title":"Salivary hydrogen peroxide produced by holding or chewing green tea in the oral cavity","volume":"41","author":"Lambert","year":"2007","journal-title":"Free Radic. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/em.22333","article-title":"Caffeic acid genotoxicity: Correlation of the pig-a assay with regulatory genetic toxicology in vivo endpoints","volume":"60","author":"Bhalli","year":"2019","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00228-005-0071-1","article-title":"Interaction between grapefruit juice and hypnotic drugs: Comparison of triazolam and quazepam","volume":"62","author":"Sugimoto","year":"2006","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.ejcn.1601309","article-title":"Tea consumption and iron status","volume":"56","author":"Temme","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_175","first-page":"518","article-title":"Excessive tea consumption can inhibit the efficacy of oral iron treatment in iron-deficiency anemia","volume":"80","author":"Gabrielli","year":"1995","journal-title":"Haematologica"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1365-277X.2003.00497.x","article-title":"Impact of tea drinking on iron status in the UK: A review","volume":"17","author":"Nelson","year":"2004","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1097\/01.ju.0000046780.23389.e0","article-title":"Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats","volume":"169","author":"Wisniewski","year":"2003","journal-title":"J. Urol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/ajcn\/60.3.333","article-title":"Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women","volume":"60","author":"Cassidy","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Gentile, M.T., Camerino, I., Ciarmiello, L., Woodrow, P., Muscariello, L., De Chiara, I., and Pacifico, S. (2023). Neuro-Nutraceutical Polyphenols: How Far Are We?. Antioxidants, 12.","DOI":"10.3390\/antiox12030539"},{"key":"ref_180","first-page":"905215","article-title":"Bioavailability of dietary polyphenols and gut microbiota metabolism: Antimicrobial properties","volume":"2015","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1021\/acs.jafc.1c07198","article-title":"Technological and biotechnological processes to enhance the bioavailability of dietary (poly) phenols in humans","volume":"70","author":"Polia","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/BPL-200099","article-title":"Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey","volume":"6","author":"Carecho","year":"2020","journal-title":"Brain Plast."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/15\/3454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:25:46Z","timestamp":1760127946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/15\/3454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":182,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["nu15153454"],"URL":"https:\/\/doi.org\/10.3390\/nu15153454","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,4]]}}}