{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:59Z","timestamp":1787029199767,"version":"build-2736575974"},"reference-count":57,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T00:00:00Z","timestamp":1691280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Local and international guidelines have provided schedules for the vitamin D supplementation of general populations of different ages, including children. Our study aimed to assess 25(OH)D concentration and its potential change during a growth and maturation period, adding parameters that reflect the risk of hypercalcemia. Materials and methods: The available 25(OH)D concentration values (n = 17,636; 7.8 \u00b1 6.0 years), calcium (n = 2673; 16.3 \u00b1 6.1 years) and phosphate (n = 2830; 3.8 \u00b1 5.2 years) metabolism markers were analyzed in a studied group of patients (0\u201318 years). Results: In the studied group the mean 25(OH)D concentration was 29.4 \u00b1 11.7 ng\/mL. Concentrations of 25(OH)D &lt; 10 ng\/mL were observed in 1.7% of patients (n = 292), 10\u201320 ng\/mL in 17.2% (n = 3039), 20\u201330 ng\/mL in 39.5% (n = 6960) and 30\u201350 ng\/mL in 37.2% (n = 6567). In patients with a 25(OH)D concentration &lt;10 ng\/mL, normal calcemia (2.25\u20132.65 mmol\/L) was observed in 29.5% of cases (n = 86). Three patients had 25(OH)D concentrations above 100 ng\/mL with co-existing hypercalcemia; the mean was Ca = 3.40 mmol\/L. Hypocalcemia (Ca &lt; 2.25 mmol\/L) was observed in 10,4% of patients (n = 2797). Furthermore, 5.0% of patients showed an increased calcium concentration &gt;2.65 mmol\/L (n = 1327). The highest mean 25(OH)D concentration of 32.1 ng\/mL \u00b1 12.9 was noted in the years 2018\u20132019 (n = 3931) and the lowest in the year 2015 (27.2 ng\/mL \u00b1 11.0; n = 2822). Conclusions: Vitamin D deficiency (&lt;20 ng\/mL) was noted in 18,9% of subjects in the years 2014\u20132019. An effective prevention of vitamin D deficiency was observed in children aged 3 years and younger. A relationship between the concentrations of calcium and 25(OH)D was not observed.<\/jats:p>","DOI":"10.3390\/nu15153477","type":"journal-article","created":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T10:01:53Z","timestamp":1691316113000},"page":"3477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["25(OH)D Concentration in Neonates, Infants, Toddlers, Older Children and Teenagers from Poland\u2014Evaluation of Trends during Years 2014\u20132019"],"prefix":"10.3390","volume":"15","author":[{"given":"Marek","family":"W\u00f3jcik","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Radioimmunology and Exerimental Medicine, The Children\u2019s Memorial Health Institute, 04-730 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Jaworski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Radioimmunology and Exerimental Medicine, The Children\u2019s Memorial Health Institute, 04-730 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-7112","authenticated-orcid":false,"given":"Pawe\u0142","family":"P\u0142udowski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Radioimmunology and Exerimental Medicine, The Children\u2019s Memorial Health Institute, 04-730 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,6]]},"reference":[{"key":"ref_1","first-page":"1153","article-title":"25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: Case-control versus nested case-control studies","volume":"35","author":"Grant","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_2","first-page":"1357","article-title":"Roles of Solar UVB and vitamin D in reducing cancer risk and increasing survival","volume":"36","author":"Grant","year":"2016","journal-title":"Anticancer Res."},{"key":"ref_3","first-page":"607","article-title":"Vitamin D supplement dose and serum 25-hydroksyvitamin D in the range associated with cancer prevention","volume":"31","author":"Garland","year":"2011","journal-title":"Anticancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"McDonnell, S.L., Baggerly, C., French, C.B., Baggerly, L.L., Garland, C.F., Gorham, E.D., Lappe, J.M., and Heaney, R.P. 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