{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:18:01Z","timestamp":1789391881681,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n MAPFRE","award":["SIP 20131913"],"award-info":[{"award-number":["SIP 20131913"]}]},{"name":"Fundaci\u00f3n MAPFRE","award":["FM\/fortalece12\/052\/2023"],"award-info":[{"award-number":["FM\/fortalece12\/052\/2023"]}]},{"DOI":"10.13039\/501100003069","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Politecnico Nacional","doi-asserted-by":"publisher","award":["SIP 20131913"],"award-info":[{"award-number":["SIP 20131913"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003069","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Politecnico Nacional","doi-asserted-by":"publisher","award":["FM\/fortalece12\/052\/2023"],"award-info":[{"award-number":["FM\/fortalece12\/052\/2023"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Morelense para el Financiamiento del Sector Productivo","award":["SIP 20131913"],"award-info":[{"award-number":["SIP 20131913"]}]},{"name":"Instituto Morelense para el Financiamiento del Sector Productivo","award":["FM\/fortalece12\/052\/2023"],"award-info":[{"award-number":["FM\/fortalece12\/052\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Irritable bowel syndrome displays three different subtypes: constipation (IBS-C), diarrhea (IBS-D), and mixed (IBS-M). Treatment with dietary fiber is used, with consideration given both to the chemical composition of the fiber and to the different subtypes of IBS. The IBS-D subtype is usually treated with a low-FODMAPs diet, whereas the IBS-C subtype suggests prebiotics and probiotics to promote microbiota restoration. The aim of this study was to assess the effects of employing agave fructans as the soluble fiber of a jelly (Gelyfun\u00aegastro) containing 8 g per serving in the IBS-C group (n = 50), using a randomized, double-blind, time-limited trial for four weeks. We evaluated changes in the frequency and types of bowel movements through the Bristol scale, and the improvement of the condition was evaluated using quality of life (IBS-QOL) and anxiety\u2013depression (HADS) scales. The main results were that the number of bowel movements increased by more than 80%, with at least one stool per day from fifteen days onwards, without a laxative effect for the group treated. Finally, the quality of life with the prebiotic jelly was significantly improved compared to the placebo in all specific domains, in addition to significantly reducing anxiety and depression.<\/jats:p>","DOI":"10.3390\/nu15163526","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:24:47Z","timestamp":1691663087000},"page":"3526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-0782","authenticated-orcid":false,"given":"Brenda","family":"Camacho-D\u00edaz","sequence":"first","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos, Instituto Polit\u00e9cnico Nacional, San Isidro, Yautepec 62731, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Arenas-Ocampo","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos, Instituto Polit\u00e9cnico Nacional, San Isidro, Yautepec 62731, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla","family":"Osorio-D\u00edaz","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos, Instituto Polit\u00e9cnico Nacional, San Isidro, Yautepec 62731, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Jim\u00e9nez-Aparicio","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos, Instituto Polit\u00e9cnico Nacional, San Isidro, Yautepec 62731, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Alvarado-Jasso","sequence":"additional","affiliation":[{"name":"Centro Nacional de Tecnolog\u00eda y Seguridad Alimentaria (CNTA), Crta-Na134 km 53, 31570 San Adri\u00e1n, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-5790","authenticated-orcid":false,"given":"Ed\u00e9n","family":"Saavedra-Briones","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Aut\u00f3noma del Estado de Morelos, Vista Hermosa, Cuernavaca 62290, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Valdovinos-D\u00edaz","sequence":"additional","affiliation":[{"name":"Laboratorio de Motilidad Gastrointestinal del Departamento de Gastroenterolog\u00eda, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"G\u00f3mez-Reyes","sequence":"additional","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Campus Ciudad de M\u00e9xico, Calle del Puente 222, Col Ejidos de Huipulco, Tlalpan, Ciudad de M\u00e9xico 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.rgmx.2016.01.004","article-title":"Consenso Mexicano Sobre El S\u00edndrome de Intestino Irritable","volume":"81","year":"2016","journal-title":"Rev. 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